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Zopipure (Eszopiclone)

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Zopipure is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is slightly effective for this use. Zopipure is the active dextrorotatory stereoisomer of Zopipure, and belongs to the class of drugs known as cyclopyrrolones. It is also classified as a therapeutic sedative hypnotic and pharmacological cyclopyrrolone.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Plaquenil, Levothroid, Moduretic, Zyloprim, Fasigyn, Neodrea, Alprastan, Bukatel, Unicontin, Clendix, Protogyl, Paxiza, Sumycin, Brumol,

Also known as: Eszopiclone


Zopipure (eszopiclone) is a sedative, also called a hypnotic. It affects chemicals in your brain that may be unbalanced in people with sleep problems (insomnia).

Zopipure is used to treat insomnia.

Zopipure causes relaxation to help you fall asleep and stay asleep.


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Zopipure only if you are able to get a full night's sleep before you must be active again. Never take this medication during your normal waking hours, unless you have at least 8 hours to dedicate to sleeping.

Take Zopipure with a full glass of water.

Avoid taking Zopipure within 1 hour after eating a high-fat or heavy meal. This will make it harder for your body to absorb the medication.

Zopipure is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take Zopipure for longer than 2 weeks without your doctor's advice.

You may have withdrawal symptoms if you stop taking Zopipure after taking it over several days in a row. Do not stop taking Zopipure suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.


In clinical trials with Zopipure, one case of overdose with up to 36 mg of Zopipure was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Zopipure overdoses up to 270 mg (90 times the maximum recommended dose of Zopipure) have been reported, in which patients have recovered. Fatalities related to Zopipure overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others. It is against the law.

Side effects

The most common side effects associated with Zopipure are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Zopipure can cause side effects that may impair your thinking or reactions. You may still feel sleepy the morning after taking the medication. Until you know how this medication will affect you during waking hours, be careful if you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert.

Do not drink alcohol while you are taking Zopipure. It can increase some of the side effects of Zopipure, including drowsiness.

Do not take other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxants, and medicine for depression or anxiety).

Avoid taking Zopipure during travel, such as to sleep on an airplane. You may be awakened before the effects of the medication have worn off. Amnesia (forgetfulness) is more common if you do not get at least 8 hours of sleep after taking Zopipure.

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