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Zofran

Zofran is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. Zofran works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Other names for this medication:
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Also known as: Ondansetron

Description

Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Zofran ODT may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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In the second model, mechanisms of tumorigenesis distinct from classical pheochromocytoma susceptibility genes are discussed in the context of a novel putative suppressor of neural crest-derived tumors, the KIF1B beta gene. The principle and equipment of photothermal radiometry probing of scars in the internal surface of a thin metal tube are described. A randomized comparison of haloperidol plus dexamethasone versus prochlorperazine plus dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for breast cancer. The c143 MAb recognized the transfectant expressing BoLA-DR but not BoLA-DQ. User satisfaction with child psychiatry outpatient care: implications for practice. Nitric oxide (NO) is able to regulate the expression of a number of inflammatory mediators. In addition, we compare this modality with conventional electrosurgery.

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Astrocytic regulatory functions: A possible target for CNS effects of organic solvents. Further investigations are warranted to clarify the modes of SFTS virus transmission, while vector management, education on tick bite prevention and personal hygiene management should be implemented for high risk groups in endemic areas. Male-female (sex) differences in leprosy patients in south eastern Nigeria: females present late for diagnosis and treatment and have higher rates of deformity. Secondary healing is typically characterized by three overlapping stages: the initial inflammatory response, callus formation (soft and hard callus), initial bony union and bone remodeling. Methanolic extracts obtained from male and female hosts elicited action potentials in taste neurons housed in antennal sensilla chaetica, indicating that these sensilla are involved in the perception of non volatile host kairomones. Macrophage migration inhibitory factor in the human prostate: identification and immunocytochemical localization. We have shown that training, the use of experienced interviewers, written instructions, supervision and educational meetings do not automatically prevent interviewer effects. WIN can inhibit the invasion and migration of SMMC-7721 cells through down-regulating the protein expression of MMP-14. Novel perspectives on hypothalamic-pituitary dysfunction as a risk factor for non-alcoholic fatty liver disease.

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Mathematical models were constructed to explain the effect of surfactants on biodegradation. Resection of protruding mandibular angle through combined external and intraoral approach. The repeatability of measurements was assessed using the within-subject standard deviation and coefficient of variation (CoV). Polyethylenimine condensates were more compact than lipospermine condensates and both produced more homogeneously compacted plasmids when used in a 2-4-fold charge excess. Adrenocortical carcinoma with tumor thrombus extending via an adrenal vein into the inferior vena cava is uncommon. The efficiency is different for different dissolved substances contained in the solution.

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Clinical features and outcomes of neonatal sepsis caused by resistant Gram-negative bacteria are not well described in Jordan. Predictive performance of adding platelet reactivity on top of CRUSADE score for 1-year bleeding risk in patients with acute coronary syndrome. Hepatitis C Virus Protein Interaction Network Analysis Based on Hepatocellular Carcinoma. Fixed duration therapy (FDT is ativan a sedation drug ) in MB leprosy (clinicobacteriological experience). The region-specific enriched cDNA library was then screened by using the exon trap products as complex probes. Reverse transcriptase-polymerase chain reaction analysis revealed KGF mRNA expression in the mesenchymal component of the 13-day embryonic lung, while message for KGF receptor (KGFR) was expressed in the epithelium, confirming the paracrine nature of KGF/KGFR axis. This difference was largely explained by differences in cholesterol levels. The subject is able to readjust his or her head position accurately during a study, should motion occur. It has an open reading frame of 3441 base pairs which can code for a protein of 128,353 Da.

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Studies of the polysaccharides on cancer tissue with special reference to the reaction of the interstitial tissue. In contrast, the translational gene rps2 is retained in all plants investigated but has experienced rate accelerations in several hemi- as well as holoparasitic lineages, suggesting that there may be substantial molecular evolutionary changes to the plastid genome of parasites before the loss of photosynthesis. Fifty eight people (aged 41-58 years, mean 50) with chronic knee pain, with or without radiographic knee osteoarthritis, were examined with bone scintigraphy. Using the suspended twin-core fiber, the fringe pattern is due to the differential optical patch of the light in the two cores associated with a refractive index difference arcoxia 60 mg generic name of approximately 10(-3), which indicates an advantage of this approach compared with those based on high-birefringent fibers, namely, the possibility of using a small length of fiber. Many women in mid or later life from Central and Eastern Europe commute for live-in 24-hour care work to Austria. The rate of synthesis of the sigma70 polypeptide was reduced in the rpoB114 rpoD800 double mutant compared to the rpoD800 mutant, whereas the half-life of the mutant sigma70 polypeptide after temperature shift-up was the same in both strains. Analysis of B cell autoepitopes and mechanisms for autoantibody production in autoimmune diseases. Discussion and considerations for the excretion mechanism of perfluorochemical emulsion.

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Activation of caspases, downregulation of anti-apoptotic Bcl-2 expression, and upregulation of pro-apoptotic Bax protein were also observed in WECM-treated cells. Individuals with adverse events during the study had poorer functional status at baseline. This study assessed trauma patient outcome after the PHTLS program. Cardiovascular responses is methotrexate cytotoxic drug to an intravenous challenge dose of clonidine (1.5 micrograms/kg) were measured in eight patients with DSM III panic disorder. An olfactory receptor database (ORDB) is being developed to facilitate analysis of this large gene family. Assessing the stability of alanine-based helices by conformer-selective IR spectroscopy. In the middle trunk, the highest ratio was the posterior division. The rabbits were divided into three groups and killed at 3, 7 or 10 days after implantation of cement. Stability of two cluster solutions in pulse coupled networks of neural oscillators.

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To evaluate the effect of catheter tunneling on internal jugular catheter-related sepsis in critically ill patients. The literature describing quality issues in memory clinics is reviewed against a multi-dimensional framework for assessing quality standards. In addition, we observed the eGFP fluorescence in the SCN and recorded the electrophysiological properties of a dissociated SCN eGFP-positive neuron. Lipid peroxidation was estimated by the TBA test, whereas x-ray effect was estimated by clonogenic assay. We hypothesize that the surgical site marking used by the marker which is non-sterile and reused on multiple patients, may affect the surgical preparation and potentially contaminate the surgical field. The celebrex 200 mg prospect samples were representative of those commonly used in the North Atlantic Treaty Organization (NATO) military forces (e.g., 5.56 mm NATO), law enforcement agencies (e.g., 9 mm Parabellum), and encountered in war injuries and crime-related trauma (e.g., 7.62 mm Kalashnikov). Corticogeniculate feedback and visual processing in the primate. If behavioral predisposing factors could be identified early, targeted obesity prevention should be offered.

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Soccer players, despite intensive medical follow-up, have significant oral health problems such as untreated caries, gingivitis or malocclusion, and suffer dental trauma as a result of sports activities. Treatment of ROCKi increased the ratio of type I/II collagen double positive cells derived from the inner meniscus. A tendency toward a decline in TAFI is of unknown clinical relevance so far, and awaits further research. Musculoskeletal disorders significantly contribute to staff sickness and absence in the NHS. 262, 7859-7864), we demonstrated that the pro-sequence consisting of 77 amino acid residues at the amino terminus of subtilisin is essential for the production of active subtilisin. During this aggressive operation, the anaesthesiologist is faced with potential problems such as major transfusion requirements, hypothermia, intraoperative position changes, the need to transport the patient to the intraoperative radiation therapy applicator, and the risks associated with remote monitoring of the patient during the 10 min intraoperative radiation therapy application.

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The fibrous tissue of the articular disc of the dysfunctional temporomandibular joint undergoes deep and variable structural modifications. Engineered LI skin demonstrated restoration of cutaneous barrier function measures to levels seen in epidermis regenerated by keratinocytes from patients with normal skin, indicating functional correction in vivo of the proposed primary pathophysiologic defect in LI. The aim of the present study was to assess the clinical profile and outcome of tetanus patients in a referral hospital, Northwest Ethiopia. The mean survival time from diagnosis of appendicular OSA was 188 days (range 69-363 days) and from diagnosis of hepatic metastases was 35 days (range 2-69 days). Regeneration of sudomotor and sensory nerve fibres after digital replantation and microneurovascular toe-to-hand transfer. Transcriptional regulation of prostaglandin-H synthase-2 gene in human trophoblasts. A prospective randomized controlled study, titled Stories to Promote Information Using Narrative trial, was performed. Effects of white organic light-emitting devices using color conversion films on electroluminescence spectra. The initial cords that formed were complex and branches were common. This raises the concern of possible impairments of psychomotor performance in this dosage range.

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