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Zocor (Simvastatin)
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Zocor

Zocor belongs to a group of medicines called statins. It's used to lower cholesterol if you've been diagnosed with high blood cholesterol. It's also taken to prevent heart disease, including heart attacks and strokes.

Other names for this medication:
Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Also known as: Simvastatin

Description

Zocor (simvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

Zocor is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Zocor is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Zocor is used in adults and children who are at least 10 years old.

Dosage

Take Zocor exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Zocor is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Zocor, you may need frequent blood tests at your doctor's office.

You may need to take Zocor on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Zocor is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Zocor dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zocor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking Zocor.

Avoid eating foods that are high in fat or cholesterol. Zocor will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

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Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions. All annexins share the property of binding to phospholipids in the presence of calcium. Recombinant human erythropoietin was given to uremic patients at a dose of 2,000 IU subcutaneously three times a week. Politics and South African mental health: hope, truth, and reconciliation. This is particularly the case in the pre-term neonate but may have an application in the infected intensive care patient. ADH2 genotypes were performed on 404 pregnant high-risk women and 139 infants as part of a larger study of alcohol use in pregnancy. The activity of myeloperoxidase in the monocytes decreased with culture. It is suggested that spinal axons originating from paraventricular neurones can provide a direct influence on adrenal medullary function, that vasopressin is a possible neurotransmitter involved in some of these connections and this is one means by which the paraventricular nucleus can generate a defence to stressful stimuli. Moving up the career ladder in a single organization can no longer serve as the benchmark of success.

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Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives. Revision Tibiotalocalcaneal Arthrodesis With a Pseudoelastic Intramedullary Nail. Only stable disorders in the barrier properties of the cytoplasmic membranes are of a critical importance for the cell viability. We report a case of acute disseminated intravascular coagulation (DIC) developed during menstruation in an adenomyosis patient. A correlation between phorbol diester-induced protein phosphorylation and superoxide anion generation in HL-60 cells during granulocytic maturation. Differential zinc accumulation and expression of human zinc transporter 1 (hZIP1) in prostate glands. The goal of this study was to assess the impact of therapeutic massage on the quality of life of patients undergoing treatment for breast cancer. The orientation of the expression cassette replacing E1 in the vector backbone had a significant effect on the level of transgene expression, with vectors containing expression cassettes directed towards the right end of the Ad genome expressing 7-fold higher levels of beta-galactosidase (beta-gal) than those with inserts in the opposite orientation. Presentation of a case of simultaneous ectopic and eutopic pregnancy.

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The clinician can visually distinguish the normal gait pattern from abnormal patterns to assist in the diagnosis of musculoskeletal abnormalities (diseases). Of these, we successfully generated three antibodies that preferentially recognise human compared with mouse SOD1 and RRP1 proteins on western blots. Exogenous bradykinin (Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) is cleaved at Pro7-Phe8, Phe5-Ser6, and Gly4-Phe5, as demonstrated by high performance liquid chromatography analysis. Tight regulation is particularly important in this case as IFN- singulair 5 mg dose beta is highly toxic to the E. The general 14-bed intensive care unit of a university hospital.

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Monitoring the effects of high pressure processing and temperature on selected beef quality attributes. This study characterized the protective efficacy and immune response to MLVs from C-PRRSV (CH-1R) or HP-PRRSV (HuN4-F112) in a challenge using HP-PRRSV (HuN4). Based on experimental observations, we have built a computational model to further illustrate and explore the effect of the SRR process on the formation of long-term memory. Crude microsomes fortified with NADPH catalysed 25-hydroxylation of vitamin D3 to a very low extent, and this activity was not linear with the amount of microsomal protein. nov., a piezophilic sulfate-reducing bacterium from the Indian Ocean and reclassification of four species of the genus Desulfovibrio. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. This suggests that under physiological conditions where the cytoskeleton is intact, a dephosphorylation event is required for loss of high affinity binding to hsp90 that is required for receptor translocation through the cytoplasm to the nucleus along cytoskeletal tracts. A qualitative study of the views of women aged 18-29 on over-the-counter availability of hormonal emergency contraception.

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Immunisation coverage among adolescents in a Swiss juvenile correctional facility. Paraplegia rates have diminished from 8 to 10 per cent down to 1 to 2 per cent in association with these therapeutic advances. Meanwhile, the protein expression of beta-catenin and mRNA expression of TCF-4 were decreased significantly in BE1-axin cells than that in BE1 or vector control cells. The results support the sensitivity to change of the DLQI in this population. An innovator in military medicine (on the centenary of the birth of N. A self-report questionnaire designed specifically for the Genetics of Sex and Aggression sample was used to measure sexual interest in and sexual behavior toward children and adolescents. The doctor/patient relationship, confidentiality and public responsibility. Role of cation-pi interactions to the stability of thermophilic proteins. Anticoagulated female patients with atrial fibrillation had a similar rate of cardiovascular death and SSE, but a lower risk of major bleeding, compared with males. The study highlights the important trend in drug resistance in P.

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Resolution of nodular lymphoid hyperplasia of the gastrointestinal tract following chemotherapy for extraintestinal lymphoma. Tooth-whitening methods include the use of peroxide bleaching agents to remove internal discolorations or abrasive products to remove external stains. We analyzed the redistribution of nuclear proteins, PML protein, Ku70/Ku80, a putative spliceosome associated protein, pNMM102 and a nucleolar proliferating antigen, p120 after adenovirus 5 (Ad5) infection using immunofluorescent staining. The intent therefore, is not simply for nurses or midwives to learn moral philosophy or to copy what is considered by others to be right action, but to recognize that a number of right actions are possible and, in so doing, develop their ability either to choose or influence a final action through a valid process. Resolving early mesoderm diversification through single-cell expression profiling. The mechanism of regulation is not established, but does not appear to be accompanied by changes in mRNA concentrations. However, despite these effects, no growth retardation is obtained when CA4P is administered alone in a single dose. Feasibility of ultrafast computed tomography in the early evaluation of coronary bypass patency. Comparison of Conventional Versus Spiral Computed Tomography with Three Dimensional Reconstruction in Chronic Otitis Media with Ossicular Chain Destruction. Risk factors, clinical variants and therapeutic outcome of retronychia: a retrospective study of 18 patients.

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Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli. The technique can also be used at lower frequencies for more posterior tissues with similar improvement of resolution over Doppler. The dimension reduction and normalizing are implemented by the blockwise bi-directional two-dimensional principal component analysis for palmprint images to extract feature matrixes, which are assembled into an overcomplete dictionary in sparse classification. GPs are well placed to implement mass immunisation programs as long as they are supported by effective and timely communication strategies and resources. Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. Surface complexation modeling of dual-mode adsorption of organic acids: phthalic acid adsorption onto hematite. The questionnaire is an acceptable, reliable tool with high sensitivity and specificity to screen for lower urinary tract symptoms in pediatric practice. Influence of infrasound exposure on the whole L-type calcium currents in rat ventricular myocytes.

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Characterization of a family of rhoptry proteins of Toxoplasma gondii. The human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) protein has been reported to modulate the activity of the DNA repair structure-specific endonuclease subunit (SLX4) complex and to promote cell cycle arrest. Comparison of chiral separations of felodipine by high performance liquid chromatography using two cellulose tris (4-methyl benzoate) stationary phases. This study was designed to evaluate the feasibility of applying locally delivered polylactic acid microspheres for drug delivery to the arterial wall. With the rise in popularity of usage of various electronic smoking devices, there have been increasing reports of explosions, often resulting in complex injuries to the head and neck. We demonstrate that PKCzeta inhibited p53/p56 Lyn phosphorylation and stimulation in drug- or H(2)O(2)-treated cells, suggesting that p53/p56 Lyn redox regulation is altered in PKCzeta-overexpressing cells. Osteophytes were located on both medial and lateral sides, independent of the location of cartilage damage, but the size of the osteophytes was related to the amount of cartilage damage on the corresponding side. BAP1 Immunostain and CDKN2A (p16) FISH Analysis: Clinical Applicability for the Diagnosis of Malignant Mesothelioma in Effusions. Neither tunicamycin treatment of the cells nor endoglycosidase digestion of calreticulin resulted in any forms other than the 60-kD protein on sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis, suggesting that the potential site for N-glycosylation at asparagine-327 was unmodified.

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Twelve days after injury, immunohistochemical staining with a 12-LO antibody revealed intense staining in injured left carotid arteries, mainly in neointimal VSMCs and inflammatory cells, but not in the uninjured right arteries. The MIV performance was demonstrated on a big longitudinal dataset from a real web-delivered trial and using simulation. Anti-HSV-1 CTL generated following footpad infection of syngeneic mice were unable to lyse target cells expressing gB-1 or gE-1. They showed very high bromodeoxyuridine labeling indexes during the first 7 days (proliferation phase), which gradually decreased thereafter. The mitochondrial assay system usually gave smaller values than the other two methods. Nonmedicated insomnia patients showed, first, an exaggerated absolute response to both suprathreshold single- and paired-pulse stimulation compared with control participants and second, a reduced relative response to paired-pulse stimulation at long interpulse intervals (i.e., a reduced intracortical facilitation). The conventional sublabial approach remains the workhorse method despite postoperative lip edema, potential difficulty for denture wearers, and troublesome persistent upper lip and incisor teeth numbness. Bacterial Pho regulons contain genes whose rulide antibiotic expression is regulated by a specific two-component signal transduction system. Indicators of quality in research-focused doctoral programs in nursing.

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This article discusses etiologic and epidemiologic factors, diagnosis and prevention considerations, folk remedies, and common treatment options for the management of verruca. Abciximab has been shown to reduce the ischemic complications of high-risk angioplasty procedures. Laminin receptors and integrins have roles in the adhesion phase, while certain collagenases are prominent among the matrix-degrading enzymes. With the rapidly increasing number of protein-DNA complex structures available at atomic resolution in recent years, a systematic, complete, and intuitive framework to clarify the intrinsic relationship between the global binding modes of these complexes is needed. In each animal, three blood flow measurements were performed at three different ocular perfusion pressures (60-15 mmHg). Our purpose was to study aetiopathogenic, diagnostic and therapeutic aspects of ureterovaginal fistulas.

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