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Xenical is in a class of medications called lipase inhibitors. It works by preventing some of the fat in foods eaten from being absorbed in the intestines. This unabsorbed fat is then removed from the body in the stool.

Other names for this medication:
Cobese, Lipophage, Nipocut, Obelit, Obfree, Obilix, Obitrol, Olisat, Orlica, Orlimac, Orlistat, Orlitroy, Reeshape, Slimfast, Troyslim, Vyfat, Zerofat

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Also known as: Orlistat


Xenical capsules are manufactured by Roche. The active component of Xenical is Orlistat (also known as tetrahydrolipstatin) – a gastrointestinal lipase inhibitor. Xenical is recommended to control obesity in patients with the BMI greater or equal to 30 kg/m² (or with BMI greater or equal to 28 kg/m² with associated risk factors). Taking Xenical helps to lose weight, keeps from gaining it back and thus reduces many health risks that come with obesity, including heart disease, diabetes, high blood pressure etc.


Xenical is taken orally 3 times a day during the main meal or up to 1 hour after the meal. The diet of the patient should include three main meals, containing the daily dose of fat, carbohydrate, and protein. The daily intake of fat should be no more than 30% of your total daily caloric intake (e.g., eating 1200 calories per day, no more than 360 of those calories should be in the form of fat). The dose of Xenical should be omitted if a meal is missed or does not contain fat. Treatment with Xenical should not continue for more than 6 months and should be stopped after 12 weeks if patient has been unable to lose at least 5 % of the body weight. If you lose enough weight for your BMI to fall below 28 kg/m², Xenical can no longer be supplied.


If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Xenical if you are allergic to orlistat, or if you have malabsorption syndrome (an inability to absorb food and nutrients properly).

You also should not use this medicine if you have:

gallbladder problems; or if you are pregnant.

Do not use alli if:

you are not overweight; you have had an organ transplant; or you use cyclosporine (to prevent organ transplant rejection).

To make sure Xenical is safe for you, tell your doctor if you have ever had:

kidney stones; gallbladder disease; pancreatitis; underactive thyroid; liver disease; kidney disease; or an eating disorder (anorexia or bulimia).

Do not use Xenical if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight. Stop taking orlistat and tell your doctor right away if you become pregnant.

Taking orlistat can make it harder for your body to absorb certain vitamins. These vitamins are important if you are nursing a baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Xenical is not approved for use by anyone younger than 12 years old. Do not give alli to anyone under 18 years old.

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