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Tofranil (Imipramine)
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Tofranil

Tofranil is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and Tofranil. While it acts to block both, Tofranil displays a much higher affinity for the serotonin reuptake transporter than for the norepinephrine reuptake transporter.

Other names for this medication:
Alzoset, Antipres, Anxidep, Anxitab, Anxofit, Depforte, Depik, Depnil, Depranil, Deprid, Depsin, Depsodep, Depsol, Depsolam, Depsonil, Diamin, Diazariv, Elamin, Eldep, Elidep, Endopax, Estidep, Finezol, Imikon, Imilor, Iminza, Imipramine, Imodep, Impramine, Impranit, Imprax, Imprin, Lastinem, Libomin, Microdep, Nimipose, Normadep, Prazep, Talendep, Toframine

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Also known as: Imipramine

Description

Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.

Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Tell your doctor if you have a planned surgery.

Call your doctor if your symptoms do not improve, or if they get worse.

You should not stop using Tofranil suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Detailed Tofranil dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Tofranil can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tofranil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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VCSELs with aperture diameters of 6um and 11um exhibit a wide variety of emission patterns from low order Hermite- Gaussian modes to high order Laguerre-Gaussian modes. In order to improve the conformity of these treatments a number of useful characteristics of high energy (above 20 MeV) electron beams of the MM50 Racetrack Microtron have been systematically investigated and clinically applied. Yet, many learning theorists maintain a belief in a learning mechanism in which links between mental representations are formed automatically. Ascidians are known to accumulate vanadium in their blood cells (vanadocytes) at extremely high levels which correspond to about 10(6) to 10(7) times the levels of vanadium ions in seawater. Fine needle aspiration cytology revealed follicular hyperplasia in two cases and granulomatous lymphadenitis in one case. Permanent neurological deficits were observed in two patients only. Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria.

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On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. A variation on forced migration: Wilhelm Peters (Prussia via Britain to Turkey) and Muzafer Sherif (Turkey to the United States). The right hand of eight normal volunteers was studied at normal ambient pressure and during exposure to -50, -100 and -150 mm Hg with and without the MCP glove. Patients should be counselled to seek medical advice early for persistent ulcerations or deep scars of burn wounds, especially those overlying joint surfaces. A practical compact solid-state terahertz imaging system is presented. We have recently described a novel use of isolated ileum from PGP-deficient mdr1a(-/-) mice to resolve PGP- and non-PGP-dependent drug efflux and provide a definitive measure of intrinsic drug permeability without recourse to inhibitors. From the clinical database, we identified and analyzed 2875 procedures that took place across 36 centers between 2003 and 2005. Research on child neglect has found that neglected children are more likely to experience worse developmental outcomes than non-neglected children.

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Early results are encouraging, and simultaneous surgery may be beneficial. IL-6 levels were much higher in patients with alpha-hemolytic streptococcus SS than in controls with uncomplicated bacteremia due to gram-positive organisms but were comparable with those in controls with bacteremia due to gram-negative organisms. The evaluation of the REALFLU trade mark Surveillance was performed during the winters of 1999/2000 and 2000/2001. Chronic epigallocatechin-gallate improves aortic reactivity of diabetic rats: underlying mechanisms. Plasmid profile analysis proved to be more discriminating than the other techniques and made it possible to conclude that the laboratory handling of the Isolator system was a major source of coagulase-negative staphylococci in this system. Myocarditis and cardiomyopathy were diagnosed in 36 dogs from 11 litters, and myoendocarditis and restrictive cardiomyopathy were diagnosed in 51 cats.

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The Effects of Smoking on Ultrasonographic Thickness and Elastosonographic Strain Ratio Measurements of Distal Femoral Cartilage. All subjects had clinical and EEG findings compatible with SESA syndrome and at least one MRI study that did not show other underlying condition that could be responsible for the clinical presentation. She also developed a poorly differentiated adenocarcinoma in the other breast 12 years after her initial treatment. Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations. A medical approach to evaluate all patients with kidney stones is generally recommended to detect underlying systemic disorders associated with nephrolithiasis and prevent further stone formation. With conservative management, nerve recovery was complete in 6 months.

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Unfractionated Heparin Promotes Osteoclast Formation in Vitro by Inhibiting Osteoprotegerin Activity. It was postulated that these Mabs could be used to detect antigenic differences between strains of H. From April 1995 to April 1996, a pool of 10 cow fecal samples and 10 individual samples of feces from heifers, which were raised under partial (cows) or total (heifers) confinement in the Mata Region of Minas Gerais State, Brazil, were examined monthly for the presence of nematophagous fungi. Pyrazole, an effective inhibitor of alcohol dehydrogenase, was previously shown to be a scavenger of the hydroxyl radical. We present a new technique with sufficient sensitivity (sub-pmol level) for analysis of methylation of proteins in abundances typically found on proteome maps produced by two-dimensional (2-D) gel electrophoresis.

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Co-ordinate regulation of herpes simplex virus gene expression is mediated by the functional interaction of two immediate early gene products. This unique combination of properties makes this new class of intrinsic dual emitters attractive for ratiometric optical thermometry applications. True histiocytic lymphoma is considered a rare entity, and its diagnosis requires the concordance of morphological, immunophenotypic, and molecular findings. We examined the influence of different DNA isolation methods on the sensitivity of the assay. Using the NEO-Five-Factor Inventory (NEO-FFI) questionnaire, measures of the personality traits neuroticism, extraversion, openness, agreeableness, and conscientiousness were obtained. The evidence for a special role of taurine in development is considered and discussed.

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This case report indicates the importance of performing a histological examination to establish the final diagnosis of cholesterol granuloma. GGT and the glucose levels at 30 and 60 min after the 75-g glucose load were predictors of development from NGT to IGT in healthy middle-aged Japanese men. The three-dimensional fold reveals a catalytic module of approximately 160 residues, in common with the eukaryotic protein kinase superfamily, which harbours the nucleotide binding site and the catalytic apparatus in an inter-lobe cleft. Factors influencing the outcome after the operative treatment of cerebral aneurysms of anterior circulation. The seven LPB/C turned out to be SII in one case, SIII in four, and SIV in two hips.

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Sleep-disordered breathing is a common condition associated with nocturnal hypoxaemia, sympathetic activation and haemodynamic stress that can trigger arrhythmias. The inhibitory activity of the anti-RT antibody fragments is competitive with respect to the template primer. Antisense treatment did not effect cell viability or cell growth. We found that the compatibility effect did not differ significantly between vertical and horizontal presentation, adding to previous results on perceptual generality, but was nonsignificant with consecutive presentation. The purpose of this study was to compare the outcomes associated with the subxiphoid and thoracotomy pericardial window techniques, with a focus on perioperative pain and effusion recurrence rates. GVHD occurs when the transplanted allogeneic cells attack (attempt to reject) the host body.

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We applied a time-resolved small-angle neutron scattering technique to vesicle systems to determine interparticle transfer and flip-flop of phospholipids. Asymmetric cross-reactions between Mahoney and Sabin-1 strains were clearly demonstrated. Pregnant ewes were injected intramuscularly with 300,000 iu of vitamin D3 in a water miscible vehicle either 10, seven or four weeks before the expected lambing date and the effects on plasma concentrations of 25-hydroxyvitamin D3 were monitored. Four pairs of strains within a country and animal species produced identical patterns. The association between dietary fat consumption and risk of cancer, especially colon, breast, prostate, and ovary cancer, has been debated for many years.

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The action of stomatocytogenic compounds was inhibitory, and echinocytogenic compounds had no effect on low diovan 40 mg n3 pH-induced vesiculation. Further, we have developed another online tool, Cistome, for predicting or exploring cis-elements in the promoters of sets of co-expressed genes identified by such a method, or by other methods. A qualitative study of online mental health information seeking behaviour by those with psychosis. We adopted this method in a 17-day-old boy with TGA, VSD, hypoplastic tricuspid valve and diminutive right ventricle. To investigate the effect of S100A4-siRNA, the expression of S100A4, E-cadherin, and p53 proteins and their messenger RNA (mRNA) was detected by Western blot and quantitative real-time polymerase chain reaction. The temperature of the saline actually entering the patient was measured by a thermocouple attached at the connection to the central line catheter.

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This classification was useful to discriminate PA from other salivary gland tumors with NMC. Development of AEZS-115 (ZEN-019) by optimization of structurally unique, orally active, peptidomimetic GnRH antagonists. The possible origin and role of this pseudocapsule are proposed. The indications for surgery in elective and emergency cases are defined and the results reviewed critically and compared with medical treatment. Finally, the most appropriate compounds to be added to flours are suggested considering their reactivity and their possible negative effects on the stability of flour, as well as the bioavailability, market availability and cost. Confocal fluorescence demonstrates that single molecules of dye-labelled Cytochrome C or B5 containing paramagnetic Fe(III) can be magnetically placed into the interstices of super-crystal which is composed of three dimensional regular arrays of Fe(3)O(4) nanoparticles.

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Juvenile spring eruption is a variant of polymorphic light eruption. Autonomous Quality Control of Joint Orientation Measured with Inertial Sensors. We have matched these cases with a control group that showed presence of polypoid adenomatous tissue with mild to moderate dysplasia. Ifosfamide treatment increased apoptosis and caused hypoplasia of placental basal and labyrinth zones, which resulted in pathological changes in developing fetal tissue. The aim of the literature review is to describe the most frequently used and/or quoted quality of life instruments maxolon injection dosage in schizophrenia, and to describe their different characteristics and specificities in order to help clinicians to find the most appropriate one according to expectancies, possibilities and interests. This approach is a simple and generalizable strategy to augment cytoreagents while minimizing the systemic side effects of adjuvant drugs.

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In contrast to ischemia and reperfusion, there are no significant alterations in G proteins and modulation of adenylate cyclase in the stunned myocardium. Mild glucose intolerance in the elderly, as in young adults, increases the risk for the development of overt diabetes mellitus and is a risk factor for the development of atherosclerotic diseases. Treatment with tetraethylammonium (TEA) resulted in less severe clubroot symptoms. DNA strand breaks were detected following what happens if you drink alcohol with mobic in situ nick translation, and alterations in membrane integrity were evaluated following 7-AAD incorporation. Therefore, further studies on the possible mechanisms of inhibitory effects of NO production by DOX would be worth pursuing. We systematically reviewed the current literature surrounding LDL-C apheresis for FH. The range of near neutrality depends on the effective size of the population that is influenced by selected linked loci. Virtual reality in paraplegia: a VR-enhanced orthopaedic appliance for walking and rehabilitation.

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The processing of pseudorabies virus glycoprotein gX in infected cells and in an uninfected cell line. Applications of electron microcopy in dental anatomy and dentistry. Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients. Glycoprotein MUC1 is an attractive target for anti-tumor vaccine development. Traditional LCOS devices and applications such as rear projection televisions, have been based on intensity modulation electro-optical effects, however, recent developments have shown that multi-level phase modulation from these devices is extremely sought after for applications such as holographic projectors, optical correlators and adaptive optics. Induction of antitumor immunity with Fas/APO-1 ligand (CD95L)-transfected neuroblastoma neuro-2a cells. Finally the results of the clinical investigation are presented. Firearms are associated with allopurinol generic brand significantly increased risk of inhospital fatality. Framework stability and accessibility of the open channels to reagents are then addressed. Stroke patients have a high risk for recurrence, which is positively correlated with the number of risk factors.

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Polio eradication through immunization is evidenced by the documented absence of poliomyelitis in an increasing number of countries and the progressive disappearance of poliovirus genotypes. The development of its basic connections, the connections between the fan-shaped body and the protocerebral bridge, and the compartmentation of these neuropil regions were shown, using LomTK-IR neurons as marker structures. In this study, the in vitro growth-inhibitory and pro-apoptotic effects of PNAS-4 and/or cisplatin on CT26, LL/2, and SKOV3 cancer cells were assessed by MTT assay, flow cytometric analysis, DNA fragmentation, and morphological analysis, respectively. Canada-wide EDI records from 2004 to 2014 (representing over 700,000 children) will be linked to Canada Census and Income Taxfiler data. Nine calves, six of which had been infected with strain 85/BH 16TV and three with strain 85/BH 232TN of Bovid herpesvirus-4 (BHV-4), were treated with dexamethasone (DMS) three months after infection. Statistical analysis indicated a positive correlation between genotype and reproductive seasonality, with C/C genotype playing a crucial role in out-of-season reproduction activity. Ryan White CARE Act service use by Asian/Pacific Islanders and other clients in three California metropolitan areas (1997-1998). This retrospective observational study identified hospitalized patients in a French psychiatric hospital territory from 2012 to 2013.

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