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Spilactone (Spironolactone)

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Spilactone is a diuretic (water pill). It is not a weight loss medication. It causes you to urinate more to get rid of extra fluid in your body. This can cause weight loss, but this is water weight and not fat loss.

Other names for this medication:
Aldostix, Amifru, Aquamide, Dyamide, Dytor, Fruselac, Frusis, Lactone, Lasilactone, Metolactone, Spilactone, Spiromide, Spironolactone, Spirotic, Torlactone, Tormax, Torsid, Zator

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Also known as: Spironolactone


Spilactone (spironolactone) is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Spilactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood).

Spilactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.

Spilactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.


Usual Adult Dose of Spilactone for Edema:

25 to 200 mg orally per day in single or divided doses

Usual Adult Dose of Spilactone for Hypertension:

Initial dose: 50 to 100 mg orally per day in single or divided doses

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL

Usual Adult Dose for Primary Hyperaldosteronism:

Diagnostic dose:

Usual Adult Dose for Hypokalemia:

25 to 100 mg orally per day

Detailed Spilactone dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Spilactone are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Spilactone if you are allergic to Generic Spilactone components. Do not take Generic Spilactone if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Spilactone can harm your baby. Do not take Generic Spilactone if you are taking potassium-sparing diuretics (such as Aldactazide, amiloride (Moduretic, Midamor)), triamterene (such as Maxzide, Dyazide, Dyrenium)). Be careful using Generic Spilactone if you take inhibitors (enalapril (such as Vasotec), fosinopril (such as Monopril), captopril (such as Capoten), benazepril (such as Lotensin), lisinopril (such as Zestril, Prinivil), quinapril (such as Accupril), moexipril (such as Univasc), ramipril (such as Altace), trandolapril (such as Mavik)); oral steroids (dexamethasone (such as Decadron, Dexone), prednisone (such as Deltasone), methylprednisolone (such as Medrol)); aspirin and other nonsteroidal anti-inflammatory medicines (naproxen (such as Aleve, Naprosyn), ibuprofen (such as Advil, Motrin), indomethacin (such as Indocin)); diuretics; barbiturates, phenobarbital; digoxin (such as Digitek, Lanoxicaps, Lanoxin)); high blood pressure medicines, lithium (such as Lithobid, Eskalith); perindopril (such as Aceon).It can be dangerous to use Spilactone if you suffer from or have a history of liver disease, kidney disease, potassium high levels in your blood, problems with urination. Be careful with this drug if you are going to have a surgery. Avoid food with high level of salt. Avoid dehydration. Avoid medicines which cause lightheadedness. You should be careful when you are driving or operating machinery. Do not stop taking Generic Spilactone suddenly.

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Acute mesenteric the lymphadenitis in clinical practice can be surveyed as a polyetiological syndrome of the enlarged mesenteric/lymph nodes. Narcolepsy is a disabling disorder, characterized by excessive daytime sleepiness, irresistible sleep attacks, and partial or complete cataplexy. As expected, tubulin was the major protein present in the preparations. In vitro, both iron chelation with DFO and blockade of Tf-mediated iron uptake with anti-Tf receptor antibody 42/6, stimulated EPO production in serum-deprived hepatoma cells. Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression. Radio-iodine induced athyroid joint disease in mice of different strains. Since the biological processes that regulate the effects of locally administered opiates are in flux during the early postnatal life of the rat, it is not clear whether or not opiates given directly into local tissue would be effective as analgesics.

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We present an all-optoelectronic THz imaging system for ex vivo biomedical applications based on photomixing of two continuous-wave laser beams using photoconductive antennas. These results support a relationship between gender, apolipoprotein E genotype and glucose metabolism, but do not indicate that mild changes in glucose have an important impact on cognitive function. The nanoband array architecture allows for efficient diffusion of glucose and oxygen to the electrode, resulting in a thousand-fold improvement in sensitivity and wide linear range compared to a conventional electrode. In all experiments, AMPA receptors were blocked by continual application of CNQX (10 microM). Posttranscriptional control of the bactericidal ColE7 operon has been implicated by a feedback endonucleolytic cleavage of its own mRNA. ferax can kill amphibian larvae and further suggest that evaluation of how pathogens affect amphibians at the population level requires investigation at various life stages.

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Uptake and effects of the cypermethrin-containing sea lice treatment Excis in the marine mussel, Mytilus edulis. Thus, histidine was concluded to be the direct precursor of the nitrogen atom of the pyrimidine moiety of thiamin in S. To investigate the effect of hypothalamus kisspeptin on water and sodium excretion and the possible mechanism. The insert with the verified DNA sequence was subcloned into two expression vectors and expressed in E. Spinocerebellar ataxia type 1 (SCA1), due to an unstable polyglutamine expansion within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), decreasing motor coordination and causing death within 10-15 years of diagnosis. In this study, we have tried to find out whether tumor-associated antigen (TAA) expression in these xenogenized tumor cells can be modulated by xenogenization.

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Acid hydrolysis and paper chromatography indicate in a preliminary fashion that there are about nine amino acids present in the intact polypeptide. Accuracy of computed tomography and magnetic resonance imaging in staging bronchogenic carcinoma. In a consecutive prospective series of 203 gastric carcinoma patients, expression of cathepsin D in tumor cells was semiquantitatively analyzed with immunohistochemistry (scored 0-3). Consistent with the UK results, New Zealand healthcare professionals rated their skills in advising patients about physical items of burn rehabilitation higher than their skills for psychosocial items. Uric acid (UA) is an independent risk factor for the development of coronary heart disease. Treprostinil Administered to Treat Pulmonary Arterial Hypertension Using a Fully Implantable Programmable Intravascular Delivery System: Results of the DelIVery for PAH Trial. These infusions did not alter significantly the locomotor activity, pentobarbital induced sleeping time and body temperature, with the exception of H.

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This is consistent with statistical data showing that TAT-targeting signal peptides in general have less hydrophobic h-regions than Sec-targeting signal peptides. Larger, prospective studies are needed in order to definitely address this issue. Tensile properties of fibroblasts (FBs) and vascular smooth muscle cells (VSMCs) of synthetic and contractile phenotypes were studied using a newly developed micro-tensile tester. Influence of sequence and size of DNA on packaging efficiency of parvovirus MVM-based vectors. Thin-layer chromatography with immunostaining revealed serum antibodies that reacted with GM1 and GalNAc-GD1a. Multiple familial pilomatricomas associated with myotonic dystrophy. Aneurysm of the small saphenous vein presenting as a popliteal mass: a case report. We evaluated clinical, biochemical, immunological and genetic features and treatment response of 163 consecutive Italian patients with autoimmune hepatitis.

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A rise in cytosolic calcium is not necessary for maturation of Xenopus laevis oocytes. A brief description of various techniques is followed by a discussion of the situations in which these techniques might be useful in assessing the cause of vision loss, and the extent and activity of the inflammatory changes. Thus, prefrontal cortex is able to sculpt behavior through parallel inhibitory and excitatory regulation of neural activity in distributed neural networks. Our results show that AAD-based speaker extraction from microphone array recordings is feasible and robust, even in noisy acoustic environments, and without access to the clean speech signals to perform EEG-based AAD. In this review, we discuss recent developments of kidney-on-a-chip platforms with current and future applications. Analysis of the cooperative thermal unfolding of the td intron of bacteriophage T4. We present a case illustrating the surgical treatment for superficial siderosis.

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HA appeared to exert its inhibitory influence on TNF-alpha, as well as stromelysin and TNF receptors, on a systemic basis. In an application of the microtitre cytotoxicity assay to injection drugs, some drugs that are widely used proved to be very cytotoxic. Interestingly, the production of ethanol was affected in a similar way by the same areA alleles, suggesting that changes in pdcA mRNA level are reflected in the changes in the level of ethanol production. The statistical significance of the associations among genotypes, clinicopathologic variables, and prognosis was assessed. These features suggested that mesangial cells played an important role in the age-related expansion of the mesangial region and thickening of the GBM. Miscellaneous treatments, II: niacin and heparin: unapproved uses, dosages, or indications. The authors report the case of a patient who had Fanconi syndrome, nephrogenic diabetes insipidus, and acute renal failure during treatment with tenofovir, a nucleotide reverse transcriptase inhibitor that recently has been approved by the Food and Drug Administration for treatment of patients infected with human immunodeficiency virus.

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The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma. One mutation results in an amino acid change at position 27 (thr to leu) while the other occurs at position 156 (asp to asn). Glycoprotein analysis for the diagnostic evaluation of platelet disorders. This frequent recombination has a significant impact on the current human immunodeficiency virus type 1 (HIV-1) epidemic as well as the development of retrovirus-based systems for gene therapy. Cervical vertebral columns (214) of South African black and white cadaver populations were examined and measured to determine the mean midsagittal and transverse diameters of cervical vertebral foramina. In recent years matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI) has emerged as a very powerful method for genotyping single nucleotide polymorphisms. In this case, there is a possibility that the ileosigmoidostomy resulted in a back flow of colonic stool to the ileum that caused the carcinogenesis of the small intestine. This pictorial review illustrates the cross-sectional imaging of several less common manifestations of aortoiliac disease.

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J(4) technique was reported for the linear measurement of dynamic phase changes in a fiber interferometer that requires no phase bias and for which the measurement is independent of random phase fluctuations. CT-guided core biopsy specimens were obtained (with 18- or 20-gauge needles) from the selected tumor before therapy and 2, 4, and 8 weeks after therapy to assess HLA-B7 plasmid DNA and gene expression. To compare the shape and volume of the lenticules of corneal tissue ablated for the correction of spherical, cylindrical, and spherocylindrical refractive errors using Boolean operations of theoretical 3-dimensional (3-D) surfaces. This case-control study involved 104 preeclamptic and 202 healthy pregnant women. Ionizing radiation induces microhomology-mediated end joining in trans in yeast and mammalian cells. We also describe the use of OCTA to detect early glaucomatous nerve damage, associated with focal reductions in peripapillary retinal perfusion. The rationale for a family systems ecological perspective is presented to highlight the critical features of effective family support programs for refugee families, followed by a discussion regarding the transitions and adaptation faced by refugee families when entering the United States. Microglial ITAM-signaling receptors are counter-regulated by immunoreceptor tyrosine-based inhibition motif- (ITIM-) signaling molecules such as sialic acid-binding immunoglobulin superfamily lectins (Siglecs).

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Restenosis is associated with an increased rate of recurrent stroke zyvox dosing in renal failure and should be monitored carefully following CAS. Evidence for a genetic basis to the enhanced total lung capacity of Andean highlanders. In addition, potential auto antigens that might lead to the disease have been identified. Although transvaginal nephrectomy is feasible in the highly selected patient with favorable intraoperative circumstances, considerable refinements in technique and technology are necessary if this approach is to advance beyond mere anecdote. Functional MR imaging (fMRI) of activation in the brain is one of the more demanding applications required of an NMR imaging instrument. 246x lines showed morphological changes in culture such as marked cellular heterogeneity, cell crowding, and the presence of multinucleated giant cells, but their tumorigenicity was not increased compared with the HBX lines. The analysis study may be helpful in enhancing the safety of the astronaut and its personal protective equipment. Infected carotid prosthetic patches (ICPP) are a rare but catastrophic complication of carotid endarterectomy (CEA). All other components have remained stable, and the supporting grafts appear to have united successfully.

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The ROAG-J enables nursing staff to detect problems in the mouth and to guide decisions related to oral health interventions. All indices improved after surgery, but only distortions and macular volume normalized. Our knowledge of the biology and immunology of HCMV, although advancing rapidly, is still a long way short of being able to predict candidate subunit vaccines based on virus encoded proteins or glycoproteins. The results show that the CTLA4-Ig coreceptor blocking agent can prolong corneal allograft survival in vascularized graft sites and that UV-B irradiation followed by incubation acarbose generic name in CTLA4-Ig may prolong graft survival better than either treatment alone. Because of the bridging effect in the co-adsorption process, the coexisting PFOS and heavy metallic cations greatly enhanced their adsorption onto the nano-oxides. Studies on the effect of taste intensity on satiation show conflicting results. Identification of the FVIII epitopes to which inhibitor Abs bind will help understanding the mechanisms of inhibitor activity, and perhaps development of new therapies. Role of the two-component signal transduction and the phosphoenolpyruvate: carbohydrate phosphotransferase systems in competence development of Haemophilus influenzae Rd. Evaluation of hepatic function in new cases of pulmonary tuberculosis due to the use of standard chemotherapy regimens I and IIB.

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Sweat patterns differ between tilt-induced reflex syncope and tilt-induced anxiety among youth. In this study we examine gene expression in the retina of Nr2e3(rd7/rd7) mutants with respect to wild-type control mice, to identify genes that are misregulated and hence potentially function in the Nr2e3 transcriptional network. The role of nesfatin-1 in the amygdala on visceral sensitivity was evaluated. Carteolol did not evoke postsynaptic dopamine receptor moduretic dosage -stimulating behavioral signs such as stereotypy and hyperlocomotion in rats. All 4963 babies born during 1987 in five randomly selected villages were followed for 1 year by a group of trained nurses who collected morbidity and mortality data on the children each time the events occurred using a structured data collection form. The subjects of this study were patients with intractable pain in donor area after conventional treatments using a transverse incision, which is parallel to posterior iliac crest. Rat alvolar macrophages demonstrated plasminogen dependent fibrinolysis in vitro which was inhibited to varying degrees by the addition of zymosan, the non-toxic particulate titanium dioxide, and the toxic dusts quartz and chrysotile asbestos. Adolescent education: an opportunity to create a Developmental Origins of Health and Disease (DOHaD) circuit breaker. In the majority of patients with vasculitides and almost half of those with rheumatism, there have been revealed antibodies against antigens of hepatitis B or C.

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