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Sinzolam (Alprazolam)

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Sinzolam is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Sinzolam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Sinzolam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alcalm, Alcicalm, Alfresh, Alpradol, Alprazan, Alprose, Alprotame, Anxit, Apsolam, Benzolam, Censir, Cooltime, Cqlam, Destres, Endolam, Mebrin, Mediprex, Mentolift, Notence, Prozolam, Samrox, Sanprazole, Somnarest, Tenolam, Trustin, Wycalm, Zoltweet

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Also known as: Alprazolam


Sinzolam (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Sinzolam is used to treat anxiety disorders and anxiety caused by depression.

Sinzolam is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Sinzolam on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


Take Sinzolam XR exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Sinzolam XR may be habit-forming and should be used only by the person it was prescribed for. Sinzolam XR should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not crush, chew, or break a Sinzolam extended-release tablet. Swallow the tablet whole. It is specially made to release alprazolam slowly in the body. Breaking the tablet would cause too much alprazolam to be released at one time.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

Your symptoms may return when you stop using Sinzolam XR after using it over a long period of time. You may also have seizures or withdrawal symptoms when you stop using Sinzolam XR.

Withdrawal symptoms may include blurred vision, trouble concentrating, loss of appetite, diarrhea, muscle twitching, numbness or tingling, or increased sensations.

Do not stop using Sinzolam XR suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.

Store Sinzolam XR at room temperature away from moisture, heat, and light. Remove any cotton from the bottle of disintegrating tablets, and keep the bottle tightly closed.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Detailed Sinzolam XR dosage information


If you have been prescribed Sinzolam for medical reasons, the best way to avoid a Sinzolam overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Sinzolam consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Sinzolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Sinzolam XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Sinzolam XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Sinzolam XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit

FDA pregnancy category D. Sinzolam XR can cause birth defects in an unborn baby. Do not use Sinzolam XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Sinzolam XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Sinzolam XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Sinzolam XR. Do not give this medication to anyone under 18 years old.

Sinzolam XR pregnancy and breastfeeding warnings (more detail)

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