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Provigil (Modafinil)

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Provigil is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder or obstructive sleep apnea. While it has seen off-label use as a purported cognitive enhancer to improve wakefulness in animal and human studies.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

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Exelon, Motrin, Antabuse, Clarinex, Mobic, Mircette, Avodart, Furadantin, Amaryl, Levaquin, Viocid, Clonzy, Flutiriv, Ebutol, Pocital, Triglow, Zomitac, Ivercross,

Also known as: Modafinil


Provigil (modafinil) is a medication that promotes wakefulness. It is thought to work by altering the natural chemicals (neurotransmitters) in the brain.

Provigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder.


Usual Adult Dose for Narcolepsy:

200 mg orally daily in the morning

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:

200 mg orally daily in the morning

Usual Adult Dose for Shift Work Sleep Disorder:

200 mg orally daily one hour prior to the start of the work shift

Usual Pediatric Dose for Attention Deficit Disorder:

Not FDA approved. Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks. Children less than 30 kg: 200-340 mg once daily Children more than 30 kg: 300-425 mg Randomized, double-blind, placebo-controlled pediatric studies have utilized an 85 mg film-coated tablet (currently not commercially available) to provide these dosages. All studies utilized a titration method but varied the length of titration (3 weeks vs 7-9 days); clinical improvement was noted earlier in the shorter titration period.

Detailed Provigil dosage information


If you overdose Provigil and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Provigil if you are allergic to Provigil components. Medications that may show increased effects or toxicity if taken with Provigil include warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), phenytoin (Dilantin) and mephenytoin (Mesantoin). Some other drugs that may increase the effectiveness and/or toxicity of modafinil. These drugs include carbamazepine (Tegretol), phenobarbital, and rifampin (Rifadin). Avoid alcohol.

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Comparison of the ligand binding properties of two homologous rat apocellular retinol-binding proteins expressed in Escherichia coli. The concordance between laboratories for the immunological methods was much worse as compared with coagulation tests. CLinical and experimental studies both indicate that the occurrence of TRI in AIDS, systemic lupus erythematosus, or viral infections is directly related to endogenous systemic or local elevations of type I interferons (interferons alpha or beta). The intima-media thickness of the posterior wall of both common carotid arteries was measured 5, 10 and 20 mm caudally to the flow-divider and the average value was used for analysis. Thus, depletion of GSH with diethyl maleate or phorone decreases urinary taurine whereas inhibition of GSH synthesis with compounds such as buthionine sulphoximine increases urinary taurine levels. These findings provide a striking example of how a splice-generated C-terminal extension of a sperm tail-associating protein mediates unanticipated centrosomal events at distinct stages of the somatic cell cycle. Clinically unsuspected pheochromocytoma is usually discovered either at autopsy or during surgical intervention for unrelated conditions, despite often enormous neoplastic masses producing and storing catecholamine (CA). Seventy ALL patients and forty-two healthy controls were enrolled in this study, and their serum NSE levels were measured using an electrochemiluminescence assay. To examine the relationship between office-hour changes in IOP, measured with the Goldmann applanation tonometer (GAT) and dynamic contour tonometer (DCT), and the corneal characteristics central corneal thickness (CCT) and corneal hysteresis (CH).

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Hepatic pneumocystosis without concomitant PCP in a patient with AIDS. The cytotoxic effects of TS on tumor cells were determined by trypan blue dye exclusion, neutral red vital staining and clonogenic assay. The effect of insulin and glucagon on splanchnic oxygen consumption. Patients with HER2-positive disease also received trastuzumab 6 mg/kg every 3 weeks. It has been confirmed that nm23-H1 gene is one of the tumor metastasis suppressor genes. Cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. The current investigation examined the cross-sectional and predictive relationships between bizarre-idiosyncratic thought and psychosocial functioning throughout the early course of schizophrenia and compared these relationships to those observed among individuals with affective disorders (i.e., bipolar disorder, manic type, and major depression without psychotic features). Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain. We examined whether these changes in haemodynamic performance and oxygenation can cause an oxygen debt and anaerobic metabolism. Endurance, that is the formation of long-term memory (LTM), is based on transient and perhaps also long-lasting changes in protein synthesis.

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To determine whether the myocardial injury size on day 2 measured after gadolinium (Gd)-mesoporphyrin and Gd-diethylenetriamine-pentaacetic acid (DTPA) administration can be used for predicting left ventricular (LV) remodeling 8 weeks later, and to monitor the structural and functional changes in the infarct, peri-infarct rim, and remote myocardium in reperfused infarction using contrast-enhanced and functional magnetic resonance imaging (MRI) MATERIALS AND METHODS: Myocardial infarction (MI) was induced in 27 rats by 1 hour of coronary occlusion/reperfusion. Clinical predictors of survival in patients treated with therapeutic hypothermia following cardiac arrest. We also evaluated the linearity, detection limits, carryover, and precision of the hsA mode. Effects of platelet activating factor on vascular permeability of the middle ear mucosa. Novel CTRC gene variations and haplotypes are associated with CP in a Chinese population. Patients were treated with 1 g of probenecid orally and either one vial of sodium sulbactam/ampicillin or two vials intramuscularly. survey, there are such data from the Russian survey and an analysis of this data indicates that the greatest alcohol use is found among young Russians who began drinking by the age of 12 and who have an antisocial orientation. In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants. Anastomotic bursting pressure (ABP) and tissue hydroxyproline concentration (HP) were measured as indicators of wound healing. The care of a child/adolescent with cancer or a blood disorder is complex and often long term, involving many interdisciplinary team members across services and geographical boundaries.

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The length of cooperative units on the thin filament in rabbit psoas muscle fibres. Analysis of the reported cases of drug-induced psoriasis lead us to the postulation of a new concept of this disease. In the long term, HFPEF had higher non-cardiovascular mortality, but lower cardiovascular mortality compared to HFREF. Scrambled siRNAs and empty lentiviral vectors were used in all experiments. Observations on the discrepancies between the frequent tonsillectomies for focal disinfection and their therapeutic results. The objective of our study was to assess the degree of satisfaction expressed by users of a child psychiatry outpatient service and to match degree of satisfaction with the dropout rate. Multiple research opportunities exist for exploring the early origins of obesity to contribute towards halting the rise in obesity prevalence.

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The inertia of sex: Henry Adams on family and the politics of unconditional love. Triton X-100 solubilized the enzyme from the membrane but high concentration of salt did not. To overcome these problems, recent research has been focused on developing new ways to formulate the plant extracts and delivering them safely with enhanced therapeutic efficacy. In addition to confirm previously described clusters, two new how to eat albendazole tablet subclusters were found. Tenosynovitis of the flexor carpi ulnaris at the wrist level was observed in 10/20 patients. The presence of HA in the interstitial tissue of the grafts is paralleled by an increased water content, suggesting a role for HA in the development of the transplantation edema. In the previous issue of Critical Care, Mankhambo and colleagues report on angiogenic factors in Malawian children with severe bacterial infection. Blockade of voltage-gated calcium channels in rat inhibits repetitive cortical spreading depression. Our work identifies a central role for mitochondria in PC degeneration in SCA1 and provides evidence for the supportive use of mitochondria-targeted therapeutics in slowing down disease progression. Intense pulsed light therapy was administered three times to the same randomly assigned side on postoperative days 1 to 2, 5 to 7, and 10 to 12.

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An efficient one-pot three-component synthesis of fused 1,4-dihydropyridines using HY-zeolite. A recombinant hybrid protein (OprFaa190-342-OprIaa21-83) was expressed in E. The experiences of 68 patients before and 80 patients after the intervention were compared (worst pain scores, duration of pain, and satisfaction). We find that 8 processing proteins are sufficient for the production of MP1 and that the tailoring enzyme TclS catalyzes a C-terminal reduction step that distinguishes MP1 from its sister compound micrococcin P2. The process was probed in vitro at high spatiotemporal resolution by time-resolved small-angle X-ray scattering using a high brilliance synchrotron source. Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation. The relation of type-1 patterns to phenergan dose child sleep clinical relevance of the reaction needs further attention. Computerized ribosomal RNA secondary structure modeling of mutants found in Rett syndrome patients and their mothers. The heart of XACML are attributes values of defined type and name that is to be attached to a subject, a resource, an action and an environment in which a subject request action on resource. Patient A was a 69-year-old man with ACE-inhibitor induced angio-oedema.

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Focal dermal hypoplasia (FDH, Goltz syndrome), is an X-linked dominant mesoectodermal developmental disorder, involving skin, skeleton, eyes, teeth, and other organs. Treatment options for localized prostate cancer based on pretreatment serum prostate specific antigen levels. The rich arsenal of control methods described above can improve the performance of single-atom devices. We investigated whether the acetylcholine, carbachol, or mannitol present in perfusing solutions can affect corneal endothelial function. Furthermore, we found Costunolide induced the loss of mitochondrial transmembrane potential, down-regulated Bcl-2/Bax ratio, encouraged Cyt-c release and caspase activation. A large bladder defect was created in 12 New Zealand White rabbits: in six the bladder was closed primarily (control group) and in the remaining six the bladder was augmented using the RISMEC technique combined with omentoplasty. Questions included if the illness had so impacted families that they needed to sell assets or significantly reduce work and/or schooling. Elastocaloric effect in CuAlZn and CuAlMn shape memory alloys under compression.

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Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. For young men, memories about successfully asserting oneself with male friends were associated with chronically high and increasingly high levels of self-esteem. In conclusion we may say that the operative approach should include simultaneously all pathological deviations of women genitalia. Congenital heart disease with cyanosis and pulmonary tuberculosis. Thus, binding of nucleoplasmic RanGTP to importin-beta probably triggers termination, i.e. Nevertheless, some surgeons decline this technique because of potentially increased trauma to the ITA with impairment of flow. Levels were quantified from serial SC samples collected from the forearm, calf, back, torso, and jaw in two studies using HPLC methods. It is concluded that, in hippocampal slices, excitatory amino acids induce neurotoxicity in a similar manner to their actions in vivo.

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Hospitalized pediatric patients with communication impairment can be accurately identified in a large hospital administrative database. The anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1Ra) is known to reduce hepatic ischemia-reperfusion injury. The therapeutic approaches considered included continuous anticonvulsant tenormin tablet therapies, intermittent therapy, or no anticonvulsant therapy. Confocal scans revealed the presence of deep stromal and pre descemetic hyperreflective polymorphous deposits. Catalytic properties of a purified phosphatidylinositol-4-phosphate kinase from rat brain.

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