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Monomet (Glibenclamide)

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Monomet is an inexpensive drug that helps to treat type 2 diabetes. It is slightly less popular than comparable drugs. Monomet is only available as a generic drug. All brands have been discontinued. Monomet is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Betrol, Bionil, Codica, Combidos, Daonil, Diabetnil, Diolin, Dutrol, Euglucon, Glibenclamide, Glibet, Glifil, Glimsug, Glinil, Glitrac, Glucomin, Gluconil, Glucored, Glucosafe, Glutowin, Glybenclamide, Glybid, Glyboral, Glybovin, Glycurb, Glymep, Iscept, Metica, Monomet, Secrin, Sugatrol, Sugnil, Sugnl, Sycored, Symet, Triglucored

Similar Products:
Actos, Pamelor, Dramamine, Famvir, Reminyl, Fosamax, Antabuse, Benicar, Utrovin, Enalapril, Cetrila, Paxor, Rhizin, Permiskin, Dulotin, Prolecin,

Also known as: Glibenclamide


Monomet comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take Monomet twice a day. To help you remember to take Monomet, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Monomet exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of Monomet and gradually increase your dose if needed. After you have taken Monomet for some time, Monomet may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Monomet helps control blood sugar but does not cure diabetes. Continue to take Monomet even if you feel well. Do not stop taking Monomet without talking to your doctor.


Usual Adult Dose for Diabetes Type 2:

Standard Monomet: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Monomet: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Monomet, micronized Monomet, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Monomet at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Monomet dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Monomet dosage information

Side effects

The most common side effects associated with Monomet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Monomet in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving Monomet.

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