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Metropast (Metronidazole)
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Metropast

Metropast belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Other names for this medication:
Aminidazole, Amodis, Anaeromet, Anegyn, Anerobia, Biatron, Colpofilin, Corsagyl, Cresac, Efloran, Emedal, Farnat, Filmet, Fladystin, Flagemed, Flagystatine, Flazole, Florazole, Giardyl, Klont, Lindoplus, Mecozol, Menilet, Menizol, Metco, Metren, Metrobac, Metrocream, Metrolag, Metrosa, Metrosept, Metrosil, Metrozin, Mtronidazole, Nalox, Orogyl, Otrozol, Rhodogil, Rosaced, Rozagel, Torgyl, Trogyl, Vagilen, Vagimid, Zyomet

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Also known as: Metronidazole

Description

Metropast (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metropast is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Metropast ER. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

The capsules can be taken with or without food. If the medicine upsets your stomach, it is best to take it with a meal or snack.

The extended–release tablet must be taken without food, 1 hour before or 2 hours after a meal.

Swallow the extended-release tablet whole. Do not break, crush, or chew it.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop using this medicine too soon, your infection may return.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times during the day. If you need help planning the best times to take your medicine, check with your doctor.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules or tablets): For amebiasis infections: Adults—500 or 750 milligrams (mg) 3 times a day for 5 to 10 days. Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 35 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 doses, for 10 days. For bacterial infections: Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 6 hours for 7 to 10 days. Your doctor may increase your dose as needed. However, the dose is usually not more than 4000 mg per day. Children—Use and dose must be determined by your doctor. For trichomoniasis infections: Adults—The tablet can be given 3 different ways: as a single dose of 2 grams, as 1 gram 2 times a day for 1 day, or as 250 milligrams (mg) 3 times a day for 7 days. The capsule dose is 375 mg 2 times a day for 7 days. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): For bacterial vaginosis: Adults—750 milligrams (mg) once a day for 7 days. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and loss of balance or coordination.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Metropast ER dosage information

Side effects

The most common side effects associated with Metropast are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of metronidazole injection in the elderly. However, elderly patients are more likely to have unwanted effects and age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving metronidazole injection.

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The development of an efficient and rapid enzyme linked fluorescent assay method for the detection of Listeria spp. Oncolytic potency of HER-2 retargeted VSV-FH hybrid viruses: the role of receptor ligand affinity. We planned to investigate the effects of different concentrations of heparin in the colon cancer cell line DLD-1. Normalizing testosterone levels in elderly men does not seem to affect the postprandial lipid metabolism to any great extent, but has favourable effects on body composition. Academic and private fellowship practice patterns are nearly identical. Activation changes with practice were associated with high functional connectivity between task-relevant areas in schizophrenia patients. The effect was weakened by endothelium denudation and nitric oxide (NO) synthesis inhibition. The high incidence of immature oocytes observed in patients with normospermic partners and low fertilization rates in previous cycles may suggest that the fertilization failure in some of these cases is due to oocyte, rather than sperm, dysfunction. Predictors of state-of-the-art management of early breast cancer in Switzerland.

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The problem of hypernegative supercoiling and R-loop formation in transcription. The spatial differential of velocity yields the velocity gradient from which the strain-rate and twist-rate tensors can be determined. With the benefit of a simpler implant procedure, long-term outcome of single lead VDD pacing is equivalent to DDD pacing in patients with AV block and preoperative normal sinus node function. The results suggest that art/trs and tat may be ideal targets for potential anti-HIV agents in AIDS therapy. Following complete resection, the ipsilateral breast was used as a rotational dermoglandular flap to provide coverage over the exposed ribs. Results of this study argue against a role for recent psychological stress as a precipitant for cerebral infarction. This can partly be attributed to delayed diagnosis and incomplete understanding of the underlying pathophysiology. The effects of changes in the Michaelis-Menten parameters for those nonlinear processes, and in the unbound fractions of the drug in blood and tissue components were investigated. These endogenous complexes behaved like the in vitro-reconstituted complexes, exhibiting low levels of associated kinase activity that could be significantly augmented by dissociation of p130. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion and generating the C5b6 complex and the terminal C complex (TCC).

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This finding represents an evidence for a relationship between the acetylation of HMG1 proteins and their biological role. Resorption of radioactive sulfate (-S3504) through the human skin. CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores. A polyclonal antibody prepared against Clostridium perfringens neuraminidase 1) detected surface expression of sialidase on human PMNs stimulated with IL-8 in vitro and on murine PMNs stimulated in vivo, but not on that of unstimulated cells, 2) recognized proteins in human PMN lysates and granule preparations that were not detected by preimmune antibody, 3) inhibited bacterial neuraminidase and human PMN sialidase activities in vitro, and 4) inhibited both pulmonary leukostasis in mice systemically infused with cobra venom factor and intrapulmonary transendothelial migration of PMNs into the bronchoalveolar compartment of mice intranasally challenged with interleukin-8. The absolute abundance of most core proteins was between 50,000 and 70,000 copies per cell, but the adaptors SOS1, SOS2, and GAB1 were found at far lower amounts (2000 to 5000 copies per cell). This gene turns out to be vasa, which is required maternally for the formation of polar granules and germ cells.

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THE PROBLEMS OF GOAL-ORIENTED PLANNING OF MUNICIPALITY HEALTH CARE. A randomized trial of two-drug versus three-drug tenofovir-containing maintenance regimens in virologically controlled HIV-1 patients. gattii from Syzygium cumini represents the first isolation from South India. An open comparison of the diabetogenic effect of deflazacort and prednisone at a dosage ratio of 1.5 mg:1 mg. Protein degradation in a LAMP-2-deficient B-lymphoblastoid cell line from a patient with Danon disease.

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Laminin immunocytochemistry and conventional microscopy were used to identify tissues and cells. Protection of drinking water resources requires addressing all relevant fecal pollution sources in the considered catchment. An estimate of the cost effectiveness of gemcitabine in stage IV non-small cell lung cancer. It is likely a better understanding of the drug-enzyme interaction will be required for rational drug development. Task Prioritization in Dual-Tasking: Instructions versus Preferences. Logistic regression analysis confirmed that use of any drug in the last year, poly-drug and early use, as well as heavy alcohol use, were related to an increased risk of screening positive. The relationship between burnout symptoms and Type D personality among health care professionals in Turkey. Although the incidence of ASCUS and the frequency of underlying dysplasia is lower in postmenopausal women than the general population, there is still a real risk that a postmenopausal woman with ASCUS has underlying intraepithelial neoplasia.

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We developed a decision-analytic model that compared a diagnostic strategy of CA only with a strategy of CTA in combination with CA for patients with intermediate pretest probability of significant CAD and indicated for CA. Single-shot and phase-shifting digital holographic microscopy using a 2-D grating. Microwave coagulation therapy refers to the use of all electromagnetic methods for inducing tumor destruction by using devices with frequencies of 2450 MHz. Pharmacokinetics of Compound D, the Major Bioactive Component of Zingiber cassumunar, in Rats. On example of three patients with septo-optic dysplasia the authors present a rare clinical entity involving combined disturbances of endocrine and neurologic systems and variable expressed clinical triad: 1) pituitary aplasia/dysplasia with pituitary hormones deficiency, 2) developmental disturbance of the middle-brain structures (corpus callosum and septum pellucidum), and 3) dysplastic changes of the optic nerve. Hundreds of mutations in ABCA4 are known to cause impaired vision and blindness such as in Stargardt disease as well as related disorders. Differentiated tactics of treatment, depending on ES complexity, with predominant performance of transpapillary endoscopic interventions and lithotripsy, was elaborated. trileptal anxiety medicine To measure the effect of Endonasal DCR on the health status of patients, using a validated outcomes measure, the Glasgow Benefit Inventory.

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The results may have an important clinical implication for understanding the differential roles of BK receptor subtypes on upper airway diseases such as allergic rhinitis and nonallergic rhinitis. Limiting dilution assays were performed in the presence and absence of cyclosporine (CsA) to distinguish between activated (primed) (CsA resistant) and naive (CsA sensitive) CTLs. Ultimately, once several antiviral agents are approved, combination strategy is likely to be incorporated in antiviral treatment for chronic HBV to suppress, prevent or minimize the emergence of resistant virus. Obtaining reliable and sophisticated expression that rivals that of endogenous genes is frequently problematic. Their actions are mediated by binding to the G-protein-coupled endothelial differentiation gene (Edg) receptor subfamily, referred to as S1P1-5 and LPA1-5, and regulate a variety of signalling pathways involved in numerous physiological processes and pathological conditions.

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Similar deletion and duplication events also occur in serial streptococcal isolates from a single patient and among related strains in a recent outbreak. Although the factor(s) regulating the gene expression of beta A-subunit in this equine tissue is currently unknown, these results suggest that activin, but not inhibin, is predominantly produced in the endometrial glands of the pregnant mare, and thus produced activin may play a paracrine or endocrine role during pregnancy in this species. Coiling of more than two 5-nm protofibrils results in cable-like structures of variable width depending on the number of protofibrils involved. Antibody IL-A165 detected CD71, which is syntenic with synteny groups U10 and U25, confirming that U10 and U25 are both are on a biarmed river buffalo chromosome. The present report describes two experiments comparing biologic effects of these laser devices. Erythropoietin (EPO) is a critical regulator for the proliferation of immature erythroid precursors, but its role as a potential cytoprotectant in the cerebrovasculature system has not been defined. The objective of this report was to stress the importance of this type of complication, in which the initial manifestation might be neuropathic pain followed or accompanied by motor involvement, and whose prognosis depends on early diagnosis and treatment.

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SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells. In vivo sister chromatid differentiation and base line sister chromatid exchanges in Channa punctatus. Our arguments are based on the approximation of the kernel by a function to which it is asymptotic. Glucose-modulated tyrosine nitration in beta cells: targets and consequences. Six articles meeting validity standards were evaluated for 12 clinical measures. However, low parasitaemia controlled by immunity may constitute a proportion of PCR positive cases, which calls for awareness of the fact that other pathogens could be responsible for the febrile disease in submicroscopic malaria. IgE-associated food allergy alters the presentation of paediatric eosinophilic esophagitis. We examined the in vitro activity of gatifloxacin, a new fluoroquinolone, compared with other quinolones, ceftazidime, and traditional Gram-positive-active agents tested against pathogens isolated from patients at 10 cancer treatment hospitals in the United States. As the VR world is built, comparative analyses are being made of control strategies, display options, and interface design.

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The MELD score is a priority allocation, and the longer the waiting time to transplantation for these recipients, the more their mortality increases. Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Computed structures are compared via total energy calculations and validated against experimental structures by comparing computed neutron diffractograms, and a final assessment is performed using vibrational spectra from inelastic neutron scattering. In contrast, organisms that reside in the mucous membranes close to the lesions predominated in infections next to these membranes. Analysis of normal human eye with different age groups using infrared images. Material selected for review included clinical trials, case reports, and surveys of practice. Clinical examination revealed point tenderness of the fourth extensor compartment. A model combining the whole embryo culture with human liver S-9 fraction for human teratogenic prediction. However, sonication of resting conidia resulted in the highest specific activity.

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Earlier, we demonstrated Zyxin influence upon Hedgehog (Hh)-signaling pathway during early patterning of the central neural system (CNS) anlage of the Xenopus laevis embryo. Yet, decades after its initial description, debate persists regarding pathophysiology, diagnosis, and treatment. We have found only three other such cases reported in the English-language literature. An EM algorithm based on Newton-Raphson equations for maximum penalized likelihood estimation approach is developed. To determine if these differences reflect variations in the signaling pathway or in the persistence of wild-type maternal products, we examined muscle precursors in embryos that lacked both maternally- and zygotically-derived gene products, called holonull embryos. Cartwheel cells, in turn, inhibit fusiform cells and other cartwheel cells. Immunodominance of seven regions of a major allergen, Cry j 2, of Japanese cedar pollen for T-cell immunity. However, to develop better prevention and treatments for the disease, determining the concrete molecular mechanisms of pathogenesis becomes pivotal to understand how the host reacts to the challenge of influenza B virus. We reviewed the literature on the effects of managed care on children with chronic conditions and disabilities.

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