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Megest (Medroxyprogesterone)

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Megest is similar to the progesterone hormone naturally produced by the body. It regulates periods, stops irregular bleeding, and helps with withdrawal bleeding in cases of amenorrhea.

Other names for this medication:
Curretab, Deviry, Empeea, Farlutal, Litmus, Medrigest, Medroxyprogesterone, Medtet, Megest, Megestone, Meprate, Orgamed, Parlutal, Premelle, Prodroxy, Regeeva, Remens, Sanigst, Topnid

Similar Products:
Amoxil, Sildigra, Caverta, Levlen, Antabuse, Zyvox, Micardis, Abilify, Roglin, Pediazole, Bactrizol, Methoxasol, Eptoin, Imotil, Predon,

Also known as: Medroxyprogesterone


Depo-Megest (medroxyprogesterone) is a form of progesterone, a female hormone that prevents ovulation (the release of an egg from an ovary). This medicine also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Depo-Megest and depo-subQ Megest 104 injections are used as contraception to prevent pregnancy.

depo-subQ Megest 104 injection is also used to reduce pain caused by endometriosis.


Usual Adult Dose of depo-subQ Megest 104 for Endometriosis:

104 mg subcutaneously once every 3 months (12 to 14 weeks) Duration of therapy: No longer than two years Comments: -For sexually active women having regular menses, the first injection should only be given within the first 5 days of a normal menstrual period or at 6 weeks postpartum, if the patient is breast feeding. -If the period between injections is more than 14 weeks, pregnancy should be ruled out prior to administering. -The impact of long-term use of the subcutaneous injection on bone mineral density (BMD) should be considered. -If symptoms return after discontinuation of treatment, BMD should be evaluated prior to retreatment. Use: Management of endometriosis-associated pain

Usual Adult Dose of Depo-Megest for Contraception:

Intramuscular injection: -150 mg once every 3 months (13 weeks) in the gluteal or deltoid muscle Subcutaneous injection: -104 mg once every 3 months (12 to 14 weeks) into the anterior thigh or abdomen First injection: -Ensure the patient is not pregnant at the time of the first injection. -The first injection should be given only during the first 5 days of a normal menstrual period, within the first 5-days postpartum if not breast-feeding, and at the sixth postpartum week if breast-feeding. Switching from other methods of contraception: -IM injection: The first injection should be given on the day after the last active contraception tablet, or at the latest, on the day following the final inactive contraception tablet. -SC injection: The first injection should be given within 7 days after the last day taking the last active contraceptive tablet, or after removing the patch or ring. Similarly, contraceptive coverage will be maintained when switching from 150 mg IM injection, provided the next injection is given within the prescribed dosing period for the IM injection. Comments: -If the time interval between injections is greater than 13 weeks, pregnancy should be excluded before administering the drug. -The efficacy of the IM suspension depends on adherence to the dosage schedule of administration. -The risk/benefit of loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, should be assessed when using this IM injection long-term. Use: Prevention of pregnancy in women of child bearing potential

Usual Pediatric Dose of Depo-Megest for Contraception:

Postmenarchal children and adolescents: Intramuscular injection: -150 mg once every 3 months (13 weeks) in the gluteal or deltoid muscle Subcutaneous injection: -104 mg once every 3 months (12 to 14 weeks) into the anterior thigh or abdomen First injection: -Ensure the patient is not pregnant at the time of the first injection. -The first injection should be given only during the first 5 days of a normal menstrual period, within the first 5-days postpartum if not breast-feeding, and at the sixth postpartum week if breast-feeding. Switching from other methods of contraception: -IM injection: The first injection should be given on the day after the last active contraception tablet, or at the latest, on the day following the final inactive contraception tablet. -SC injection: The first injection should be given within 7 days after the last day taking the last active contraceptive tablet, or after removing the patch or ring. Similarly, contraceptive coverage will be maintained when switching from 150 mg IM injection, provided the next injection is given within the prescribed dosing period for the IM injection. Comments: -If the time interval between injections is greater than 13 weeks, pregnancy should be excluded before administering the drug. -The efficacy of the IM suspension depends on adherence to the dosage schedule of administration. -The risk/benefit of loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, should be assessed when using the injection long-term. Use: Prevention of pregnancy in women of child bearing potential

Detailed Depo-Megest dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Megest dosage information

Side effects

The most common side effects associated with Megest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid smoking while you are taking Megest. Smoking greatly increases your risk of blood clots.

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