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Lonazep

Lonazep is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Lonazep was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Alrest, Anxiset, Catier, Cloam, Clonark, Clonax, Clonazepam, Clonix, Clopam, Clotas, Clotweet, Clozorix, Convaclon, Dipwell, Ection, Epcon, Escitapax, Escitrac, Esitor, Klopam, Meloprax, Norep, Nozim, Onapil, Prasilife, Ubitpam, Xenotril, Zepamax, Zeptril, Zicam

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Also known as: Clonazepam

Description

Lonazep is a benzodiazepine medication that was initially primarily used for the treatment of seizures occurring in epilepsy and for anxiety, specifically anxiety that occurs in panic disorder. Lonazep is available in tablet form (0.5 mg, 1 mg, 2 mg) and as disintegrating wafers that are taken orally.

While Lonazep is generally prescribed for the treatment of anxiety disorders, such as panic disorder, and seizure control, it is intended as a short-term treatment protocol as opposed to a long-term treatment solution due to issues with tolerance (see below). In addition to treating anxiety and seizures, Lonazep has also been used in the treatment of:

chizophrenia, especially when the individual with schizophrenia has a restless or irritable component and is not responding to antipsychotic medications.

The manic phase of bipolar disorder or for restlessness associated with depression in bipolar disorder.

Tic disorders, such as Tourette's syndrome, by acting as a muscle relaxant and producing sedation.

Restless leg syndrome.

Withdrawal from alcohol or treatment for other substance abuse or addiction issues.

Lonazep has a relatively slow onset of action (it takes a while for the drug to begin working) and a half-life of between 10 and 50 hours. As it has a relatively slow onset of action and is a longer-acting benzodiazepine, Lonazep is more suited for the treatment of anxiety, seizures, and other similar disorders as opposed to being a useful sleep aid, even though it is sometimes prescribed for that purpose. Sleep aids need to work quickly, whereas with Lonazep, a person takes the drug early in the day and doesn't have to worry about monitoring for signs of a seizure or panic attack as it stays in the system a relatively long time. Its effects last longer than those of shorter-acting benzodiazepines, such as Xanax.

As it is a Schedule IV controlled substance, Lonazep can only be legally acquired with a prescription from a physician.

Dosage

Lonazep is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Lonazep was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Lonazep in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Lonazep for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Lonazep are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

For children, the long-term effects on physical and mental/behavioral development are uncertain and may not be seen until after many years. Therefore, discuss the risks and benefits of treatment with Lonazep with your doctor.

Older adults may be more sensitive to the effects of this drug, especially drowsiness and confusion. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

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Erythrocyte deformability is related to fasting insulin and declines during euglycaemic hyperinsulinaemia in hypertensive patients. To obtain Pareto-optimal solutions of multi-objective line-seru conversion, we develop two improved exact algorithms based on reducing time complexity and space complexity respectively. Clomiphene citrate treatment was discontinued, and gemfibrozil treatment at a dose of 1,200 mg/d was started. Extensive digestion of Chinese hamster metaphase chromosomes with Alu I, Hae III and Hinf I released up to 40 distinct chromosomal proteins. Swimming-exercise increases the capacity of perfused rat liver to produce urea from ammonia and L-glutamine. The aim of this study is to describe the clinical and radiological features of moyamoya syndrome associated with Down syndrome (MM-DS) and to explore theories of moyamoya pathogenesis in these patients. The heart is perfused through a coronary line, after frustrating the MV with a multiholed disposable chest tube, and made to beat while the aorta is declamped. To achieve this goal, surgeons are either limiting the number of transabdominal trocars using laparoendoscopic single site surgery (LESS) or eliminating them completely using natural orifice translumenal endoscopic surgery (NOTES).

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Astrocytes participate in central nervous system injury, degenerative diseases and also perform macrophagic functions. New distortion-invariant correlation filters for in-plane rotation invariance are considered. The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells. Herein, the immune-mediated cell response to hepatitis C antigens was evaluated by adoptive transfers of carboxyfluorescein succinimidyl ester (CFSE) labelled splenocytes from HCV immunized mice into HCV transgenic mice. The antibacterials studied were amoxicillin, amoxicillin/clavulanate, azithromycin, cefaclor, cefuroxime axetil and clarithromycin. Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls. Our results thus describe an efficient and reliable protocol for short-term expression of potential therapeutic genes in the neuronal compartment of the inner ear. Self-excited push-pull vacuum tube oscillator is one of the most commonly used oscillators in radio frequency (RF)-ion plasma sources for generation of ions using radio frequency. We will analyze interview transcripts in triplicate using grounded theory coding techniques, including open, focused and axial coding, following the principle of constant comparison.

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Nuclear origins of brainstem reticulocortical systems in the rat. Our findings thus introduce a new aspect in the regulation of pigmentation and ascribe a novel role for gamma-GT in pigment cells. Propeptin, a new inhibitor of prolyl endopeptidase produced by Microbispora. In these studies epitope-tagged adapter subunit constructs containing wild-type p85alpha, p85alpha lacking the SH3 domain (deltaSH3-p85alpha), or p85alpha lacking the Rac-GAP/BCR homology (BH) domain (deltaBH-p85alpha) were coexpressed with either the p110alpha or p110beta PI 3-kinase catalytic subunit in HEK293 cells. The total number of lung surface metastases and the absolute weight of the lungs were both significantly lower in TTFields treated mice then in sham control mice. Therefore, this study examined the effect of pressure ulcers on the survival time of patients with advanced dementia and comorbidities. The present study describes 3 adult patients with hemolytic uremic syndrome (HUS) leading to chronic renal failure. The author discusses the direct and indirect patient care services offered and the types of injuries seen at the center.

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Comparative study of expert assessment of applications for inpatient care according to SGB XI with reference to hospital patients. A noninvasive ultrasound elastography technique for measuring surface waves on the lung. This paper reviews the current knowledge of reliability of TEAM diagnoses, including limitations of studies, and discusses the implications for practice and research and how to improve the current situation. A novel sequential difunctionalization reaction of 2-iodobiphenyl has been developed by exploiting the distinct reactivities of a palladacycle and an acyclic arylpalladium species. Characterization of suppressible mutations in the viomycin phosphotransferase gene of the Streptomyces enteric plasmid pVE138. Cyrtodactylus lateralis is a prehensile-tailed species, known from scattered lowland to mid-elevation localities in northern Sumatra.

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During the experiments more lambs died in the non-supplemented than in the supplemented group. Mapping of the antigenic regions of streptokinase in humans after streptokinase therapy. 17beta-Estradiol had no effect on either the stimulation of mRNA level by PTH or the basal level. Their arterial blood gas analysis showed that metabolic acidosis and renal function of these cases were slightly impaired. However, we anticipate that endovascular repair may become feasible in patients with PAU in the ascending aorta in the future. Rectal and prilosec breastfeeding skin temperatures were measured and manual performance was tested. The patient with bilateral foot drop had partial motor recovery and did not require an ankle-foot orthosis.

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In vitro determination of iron absorption using intestinal loops or cell lines, was also discussed in this part. This newly developed biochip biosensor, which we call ESPR for an ellipsometric SPR, provides us with a system to retrieve detailed information such as the optical properties of immobilized biomolecular monolayers, surface concentration variations of biomedical reactions, and kinetic affinity between biomolecules required for further biotech analysis. Immunohistochemical and in situ hybridization analyses were performed on endoscopic specimens using specific antibodies and riboprobes for collagen types I, III, IV, and VI and for the glycoprotein tenascin. coli in vitro, and suggest that this cytokine may impair effective antibacterial host defense in vivo. None of the authors has a financial or proprietary interest in any material or method mentioned. BRACHYTHERAPY ALONE OR WITH NEOADJUVANT PHOTODYNAMIC THERAPY FOR AMELANOTIC CHOROIDAL MELANOMA: Functional Outcomes and Local Tumor Control. Nanoparticle materials (NM) present interesting physicochemical characteristics not necessarily found in their bulky forms, and alterations in their size or coating markedly modify their physical, chemical, and biological properties. To investigate what mechanisms underlie the recruitment of these cells into the synovial fluid and tissue, we performed expression analyses of chemoattractant receptors in a related family that includes the anaphylatoxin receptors and the formyl-MetLeuPhe receptor. Detection limit (3s) obtained for the investigated metals in the optimal conditions were observed in the range of 1.64-5.68 microg l(-1).

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