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Laretol (Calcitriol)
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Laretol

Laretol is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Actical, Alfacal, Alfacalcirol, Alfarich, Alphadol, Apcical, Arachitol, Bonestat, Calasto, Calbory, Calbovic, Calcigra, Calcikind, Calday, Caldix, Caltop, Carcal, Cholical, Citroj, Denscal, Duracal, Lctrol, Novadee, Osteobel, Qpcal, Riecal, Ritoca, Roical, Rolsical, Solbiocal, Statbone, Vitalpha

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Zudena, Coumadin, Mestinon, Fulvicin, Diflucan, Ceclor, Paxil, Ditropan, Neurontin, Rocaltrol, Estilo, Tramdop, Nimotop, Glipicontin, Protam,

Also known as: Calcitriol

Description

Generic Laretol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Laretol are intestine and bone. Generic Laretol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Laretol may also act on the kidney and the parathyroid glands. Generic Laretol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Laretol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Laretol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Laretol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Laretol produces other independent beneficial effects. Laretol is also known as Calcitriol. Generic Laretol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Laretol is Calcitriol. Brand name of Generic Laretol is Laretol.

Dosage

Generic Laretol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Laretol suddenly.

Overdose

If you overdose Generic Laretol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Laretol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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We find that the electronic phase transition to the metallic state in these solutions, especially at temperatures close to the liquid-liquid critical consolute temperature, occurs from a nonmetallic, electrolytic solution containing a predominance of electron spin-paired, (diamagnetic) charged bosonic states. Hemin nutritional stress inhibits bacterial invasion of radicular dentine by two endodontic anaerobes. Clinical guidelines for immunoglobulin A (IgA) nephropathy in Japan, second version. Relationship between fluoroscopic and manometric measures of pharyngeal constriction: the pharyngeal constriction ratio. Blows to the forehead resulted in orbital roof fractures and subfrontal epidural hemorrhage in three patients. Both horses were treated aggressively with IV fluids and other supportive measures. A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients.

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Confocal microscopic observations showed that the most effective reagent to reduce P. Toward true 3D visualization of active catheters using compressed sensing. Comparison of the antibacterial activity of an ozonated oil with chlorhexidine digluconate and povidone-iodine. The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. A rudimentary central vessel ran from the developing lateral bundle to the venous sinusoid capillaries between the mesial convolutions. To observe the biomechanical change of the remodeling process of a four bundles model using semitendinosus tendon for the reconstruction of anterior cruciate ligament (ACL) in rabbits, and to explore the possibility of using braiding technique for improving the outcome for reconstruction of ACL. We report on efficacy findings and adverse events (AEs) related to these agents in this review. Although the results of the clinical endpoint studies of rIL-2 are awaited, there are now further data for rIL-2 as a stand-alone therapy for the treatment of HIV. To describe the demographics, risk behaviors, and HIV-1 subtypes in a large cohort of recently HIV-infected military personnel. Antrostomies were randomly performed by outlining a window (group A, 36 patients) or by eroding the cortical wall with a grinding insert until the membrane was visible under a thin layer of bone, before outlining the window (group B, 36 patients).

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Exposure to domestic poultry in live-bird markets was significantly associated with human H5N1 disease. Here we show that human ENDOV cleaves an RNA substrate containing inosine in a position corresponding to a biologically important site for deamination in the Gabra-3 transcript of the GABA(A) neurotransmitter. Subpopulations of spleen cells from which the adherent cells had been removed generated strong cellular responses to both H-2 and non-H-2 antigens, provided the cells were cultured in conditioned media. We used gene therapy to restore orexin signaling in a mouse model of narcolepsy. Classification of biodegradable materials using QSAR modelling with uncertainty estimation. Integrative analysis revealed that homozygous deletions of cyclin-dependent kinase inhibitor (CDKN) 2A and CDKN2B and gains of fascin actin-bundling protein 1 (FSCN1) and homer scaffolding protein 3 (HOMER3) occurred frequently in ESCC. Conduction aphasia, misrepresentations, and word representations.

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HIV replication leads to complex changes in extrinsic pathway factors, with the net effect of increasing coagulation potential to a degree that may be clinically relevant. Parvovirus and Isospora canis infection was confirmed and successfully treated. Finally, we compare neural performance with behavioral performance. Symmetrical breast reconstruction: is there a role for three-dimensional digital photography?. The gold standard of 24-h urinary albumin concentrations in preeclamptic women can be substituted with a 12-h collection. Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides. Antagonism of the sedative effects of flunitrazepam used as a hypnotic agent in neuroleptanalgesia using flumazenil administered by i.v.

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Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Bilateral simultaneous VATS for resection of bilateral posterior mediastinal bronchogenic cyst may be a useful approach. The results were good in all sixteen of the untreated feet and in twenty-six (90 per cent) of the twenty-nine feet that had been conservatively treated. The results demonstrated that there were significant alterations in expression of PCNA, CD44v6, MMP-9, erbB2 mRNA, and a dramatic decrease in telomerase activity in the HIFU group. LiveBench-6: large-scale automated evaluation of protein structure prediction servers. The results for the nine compounds investigated at low temperature conform to the results from xylitol and provide estimates of the internal vibrations of H atoms in a range of chemical environments. Immunochemical screening can be used to reduce instrumental analysis costs by its use in preliminary orange oil screening. The most important new records pertain to Lutzomyia spinicrassa in the tropical dry forest of the Atlantic coast, Lutzomyia ovallesi in the Orinoco and Amazon River watersheds regions of Colombia, and the sympatric occurrence of Lutzomyia spinicrassa and Lutzomyia quasitownsendi in the eastern chain of the Andes mountains. On the basis of the recorded data, nociceptive temperature thresholds were calculated to be approximately 44.5 degrees C for both rats and mice. The vesicles were composed of either dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine.

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A stent was then advanced over the wire and into the biliary tree. Itch is a prevalent symptom of psoriasis that impacts quality of life. Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia. Recently, some results of microarray and comparative genomic hybridization analysis have been provided as comprehensive studies of genomic instability in HCC, including mutation, deletion and DNA copy losses. We have observed a reduction in E-cadherin expression in E2 70 cells and a complete loss in C5-T8 cells. In addition, the present results demonstrated that miR-429 overexpression downregulated Sp1 protein expression, which provides evidence that miR-429 may directly target Sp1 in RCC. For some forms of keratoconus, a reduction in shear strength and cone-forming deformation may be responses to rubbing trauma. After correction for the metal content in the mineral fraction, an increase in Cd, Mn and Cu concentration during fragmentation of the organic part of the litter layer was observed for the polluted plot.

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Chromatin - RNA - protein complexes were further fractionated by means of a treatment dissociating the chromatin component. The replication and transcription activator (RTA) of gamma-2 herpesvirus is sufficient to drive the entire virus lytic cycle. HIV-infected persons in Russia experience a wide range of social, psychological, and care access problems. An underused opportunity to introduce ACE inhibitors and influence prognosis: observational study of patients undergoing aortic lipitor cost surgery. Asthma is the most commonly reported occupational lung disease in the UK.

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Effect of dissimilatory Fe(III) reducers on bio-reduction and nickel-cobalt recovery from Sukinda chromite-overburden. Cybernetic method of prognosis concerning the outcome of certain types of trauma (cranio-cerebral, thoracic, abdominal and thoracic-abdominal). The importance of more targeted efforts to train individuals to not just recognize suicide warning signs, but on how to specifically respond, is emphasized. The aim of the present review article is to evaluate, based on the currently available evidence, the potential impact of modSLA surfaces for implant dentistry. We assessed trends in IPD including trends for IPD zithromax 500 mg zithrozpack caused by penicillin non-susceptible strains before and after licensure of PCV-7 and the impact of the 2008 susceptibility breakpoints for penicillin on the epidemiology of resistance. Highlights in clinical autonomic neurosciences: sudden unexpected death in epilepsy. This case study is unique in that specific preinjury MR findings are available for direct comparison and quantitative analysis of TBI-associated changes in brain structure with neuropsychological outcome. Ophiobolins P-T, five new cytotoxic and antibacterial sesterterpenes from the endolichenic fungus Ulocladium sp.

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Radiofrequency volume reduction of gastrocnemius muscle hypertrophy for cosmetic purposes. Rapid, real-time detection of acute HIV infection in patients in Africa. P-4-VP injected into mice substitutes T cell function in the development of immunological memory. The possibility of using CF-LIBS for mineral analysis in hair is discussed, as well as its feasibility for the fast and inexpensive determination of the occurrence of heavy-metal poisoning in hair. Of the six included studies with available data, two compared gauze and tape with Opsite IV3000, two compared Opsite with Opsite IV3000, one compared gauze and tape with Tegaderm, and one compared Tegaderm with Opsite. Mini-titins in striated and smooth molluscan muscles: structure, location and immunological crossreactivity. In our experience adrenal gland metastasis can be treated safely and effectively by the laparoscopic transperitoneal anterior approach. Mdx mice displayed a significantly higher number of RFs compared to mdx52 mice in all age groups, suggesting that revertant fiber expansion largely depends on the type of mutation and/or location in the gene.

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Argon laser melting of a polymethylmethacrylate intraocular lens. Despite this fundamental role in heart noroxin dosage function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been defined. Experts in the field of PE research were contacted to identify unpublished studies. Sinus histiocytosis with massive lymphadenopathy is a rare disorder of the reticuloendothelial system with predilection for black children. The results suggest that OT-containing magnocellular neurons in the PVN are under regulatory influences of SS-containing neurons. Walking speed (over 10 m), walking capacity (distance over 6 min), and handicap (stroke-adapted 30-item version of the Sickness Impact Profile) measured by a blinded assessor.

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They can sequestrate molecular systems from solution as a function of the composition of their layers, while providing intense surface-enhanced Raman scattering (SERS) signals (see picture). To determine the effects of a policy of early discharge of stable preterm infants with home support of gavage feeding compared with a policy of discharge of such infants when they have reached full sucking feeds. Experimental studies and early-phase clinical trials suggest that mobilization of bone marrow stem cells by granulocyte-colony-stimulating factor (G-CSF) can be used to improve cardiac regeneration after acute myocardial infarction (AMI). Serial Analysis of Anterior Chamber Depth and Angle Status Using Anterior Segment Optical Coherence Tomography After Boston Keratoprosthesis. LNFGP took significantly longer time to perform, but resulted in significantly higher weight reduction and remission/improvement of comorbidities. In eukaryotic cells, mitochondria are the ATP-producing and oxygen respiring organelles. Kidney homogenates were subfractionated by differential and sucrose gradient centrifugation. Stimulus conditions were blocked according to these conditions with baseline (unisensory) performance assessed during the multisensory block. In this study, we used a reliable and highly sensitive quantitative real-time PCR assay with SYBR green I dye to detect the copy number of the SMN1 gene to determine the carrier frequency of SMA in 200 healthy unrelated, non-consanguineous couples from different part of Iran. At the adjacent level L2/L3, a posterior implant has only a minor effect on intradiscal pressure.

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To investigate the mechanistic links between PTTG1 overexpression and leukemia cell differentiation, we utilized phorbol 12-myristate 13-acetate (PMA), a well-known agent that triggers monocyte/macrophage differentiation, to analyze the expression patterns of PTTG1 in PMA-induced myeloid differentiation. We consider the modulation of autoregulation by nitric oxide and use it to illustrate the necessity for multiple experimental designs, often applied iteratively. The precautionary principle is increasingly discussed in debates about threats to health and the environment, particularly when government actions might inhibit free trade. Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. Pregnancy in a woman with homozygous familial hypercholesterolemia not on low-density lipoprotein apheresis. Statistical analyses defined correlations among DNA contents, embryo morphology and maternal age. The expression data demonstrates that ORP3, -6, and -7 are not merely redundant gene products but show marked quantitative differences in tissue expression, suggesting tissue-specific aspects in their function. This mutation is in an adult-specific alternative exon (exon 9a) which encodes a portion of the myosin head that is highly conserved among both cytoplasmic and muscle myosins of all organisms. An immediate-type hypersensitivity to water/salt-insoluble fraction of wheat proteins (gluten) has been considered to underlie in this disease. Subjects with cryptogenic focal epilepsy (CFE) seen from April 1987 to September 2011 in two twin Epilepsy Centres located in Reggio Calabria and Catanzaro, Calabria, Southern Italy, were screened.

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Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. This discrepancy was norethindrone ethinyl estradiol brand names greatest in early pregnancy and decreased as the duration of pregnancy increased. It must, however, be remembered that in patients with rapid cycling, antidepressants may re-trigger mania. Evidence for two sites of inhibition comes from the fact that both reduced nicotinamide adenine dinucleotide menadione reductase and duroquinol oxidase activities are inhibited. Differences in the infectivity of Babesia incubated in plasma and serum and the role of glucose in prolonging viability. Simulations of human brain rhythms were carried out in order to test the model.

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Extracellular Self-DNA (esDNA), but Not Heterologous Plant or Insect DNA (etDNA), Induces Plasma Membrane Depolarization and Calcium Signaling in Lima Bean (Phaseolus lunatus) and Maize (Zea mays). The extracellular region is characterized by the presence of a sema domain (a stretch of approximately 500 amino acids with several highly conserved cysteine residues), a PSI (plexin, semaphorins, integrins) domain, and four immunoglobulin-like folds. Cholesteric liquid crystal laser in a dielectric mirror cavity upon band-edge excitation. Furthermore, the transcript level of various plastid- and mitochondria-encoded genes was severely reduced in the NbBTF3-depleted leaf cells. Social cognition is a topic of enormous interest and much research, but we are far from having an agreed taxonomy or factor structure of relevant processes. Simply wearing footwear could interrupt transmission of Strongyloides stercoralis. No significant difference was found between the two groups for total duration of the surgery, complications, anatomical results, visual outcome, and buckle height. Results showed habitat-specific differences in soil and invertebrate metal concentrations and bioaccumulation factors when normalized to soil metal concentration. The sessions were designed to teach inmates ways of restructuring faulty thinking and improving social skills. To examine possible mechanisms of these effects, we assessed the effects of VS DBS on the expression of the neural activity marker Fos and brain-derived neurotrophic factor (BDNF), a key mediator of extinction plasticity in prefrontal-amygdala circuits.

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The aim of this study was to investigate mechanisms of motor-cortical excitability and inhibition which may contribute to motor hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Previous results indicate that peripheral administration of secretin leads to robust Fos protein expression in the central nucleus of the rat amygdala. Inhibition of UVA and UVB radiation-induced lipid oxidation by quercetin. The findings showed that although teeth tended to tip towards the extraction space, the amount of tipping was small (not exceeding 15 degrees in the majority of cases). Analysis of gender (in)equalities in health and quality of life in informal caregivers. Its significant improvement in children with low levels of postural stability is important not only for the current functioning of those children but for their future - by protecting them from falling down and from injuries. Participants were followed up 1 and 4 years later and new episodes of CAP were identified. Most types of incidents were less frequent at weekends and midweek. A lateral rhinotomy incision is employed and when necessary, this exposure is increased by extending the incision of split the upper lip and reflect the cheek flap as is customarily done with the Weber-Ferfusson incision. No significant changes could be found in the acetylation state of the other core histones at the acetylation sites examined.

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Theoretical and experimental investigation of actively Q-switched Tm,Ho:YLF lasers. There is a trend for longer courses of hemodialysis in these patients, which leads to an increase in cumulative drug exposure, complexity of drug interactions, and potential toxicity. This qualitative study sought to elucidate the similarities and differences in communication with physicians between Chinese and NHW breast cancer survivors. Immunoadsorbents for clinical use: ex vivo immunoglobulin E removal in allergy. Both, the RNase H domain and the connection subdomain contribute substantially to polymerase integrity and stability as well as to polymerase activity and substrate binding. A 39-kD protein, immunologically related to Escherichia coli RecA, is present in chloroplasts of pea (Pisum sativum L.).

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