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Lagesic (Tramadol)

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Lagesic is used for the management of pain in adults. Although it's a little weaker than other opioids, it can still be addictive and habit-forming. Lagesic is available as both an immediate-acting tablet and an extended-release tablet.

Other names for this medication:
Anatram, Anazac, Axedol, Bludol, Cadol, Cemadol, Combitram, Esgiypyrin, Lagesic, Movon, Nopidol, Pacadon, Sedate, Takol, Tamody, Tandam, Tolydol, Topspas, Tragesic, Tramafen, Tramaflam, Tramataur, Tramazac, Tramed, Tramol, Tramospas, Trandol, Tranzat, Trapain, Trasic, Trazac, Trugesic, Tryme, Ultrax, Ultrazac, Urogendo, Vardol

Similar Products:
Geodon, Kamagra, Rogaine, Bactrim, Zanaflex, Xeloda, Monomet, Zomet, Editrim, Escodaron, Suplar, Lipofen, Odazyth, Distaclor, Scordom,

Also known as: Tramadol


Lagesic ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Lagesic: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Lagesic is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Lagesic dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Lagesic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Lagesic if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Lagesic should not be given to a child younger than 12 years old. Lagesic ER should not be given to anyone younger than 18 years old.

Do not give Lagesic to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Lagesic. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Lagesic is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Rapid and effective oxidative pretreatment of woody biomass at mild reaction conditions and low oxidant loadings. Several closely related disease entities make up the idiopathic hypereosinophilic syndrome (HES). Thus, both the auditory-only mode and the auditory-visual mode were effective. Analyses of the powder line shapes and oriented sample relaxation data for both the glycerol backbone and head group regions of this lipid have been performed. Additional cells were cultured with 20 ng/mL of IFNgamma for 90 min or 5 ug of antibody to IFNgamma for 48 h, and then stimulated with IL-4. Generation of accurate peptide retention data for targeted and data independent quantitative LC-MS analysis: Chromatographic lessons in proteomics. This study provides novel evidence that the developmental exposure to MeHg can affect not only cognitive functions but also motivation-driven behaviors. Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study. Using an ARGO with dorsiflexion-assisted AFOs increased the fear of falling, but improved static postural stability and increased walking speed and endurance, and should therefore be considered as an effective orthosis during the rehabilitation of people with SCI. to examine the perceptions and experiences of midwifery educators, in south-west England, about the challenges facing them sustaining the education workforce of the future.

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The success rate of choledochoscopic removal of intrahepatic stones was 76.8 per cent. Diagnoses-based cost groups in the Dutch risk-equalization model: the effects of including outpatient diagnoses. The calcitonin gene-related peptide-induced relaxation was increased in segments from spontaneously hypertensive rats. The children (aged 5-12) showed similar results on a single-digit timed addition task-right-starters outperformed left-starters. Conservation strategy for Pelargonium sidoides DC: phenolic profile and pharmacological activity of acclimatized plants derived from tissue culture. A 12-year-old male was presented with macular coloboma in the left eye. Gene therapy: potential applications in clinical transplantation. I found that discrimination thresholds correlate with stimulus contrast to the background. This study examines whether overweight in midlife increases dementia risk later in life.

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Neuromuscular deterioration in the early stage of sepsis in rats. Conversely, high amounts of Bcl-2 per cell allow high amounts of Bim, although in this case the effect involves increases in Bim mRNA. Histomorphometric evaluation of implant design as a key factor in peri-implant bone response: a preliminary study in a dog model. The current status of organic synthesis is hampered by costly protecting-group strategies and lengthy purification procedures after each synthetic step. Clinical diagnosis has been difficult because of aspecificity of symptoms that mimed other more common diseases, like gastro-paresis, epigastric discomfort, gastric or duodenal ulcers, perforation, malabsorption, intestinal pseudo-obstruction. As one of the most important skills mastered by medical volunteers serving for Mt. (iv) Adding Ficoll to the pronase solution increased the yield of viable CFU-C. Plasma and urinary concentrations of candidate markers were measured using liquid chromatography-mass spectrometry. Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. The effectiveness and safety of the treatment requires further assessment.

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Efforts to transfer SAA from sensitized donors to either normal or primed recipients, employing lymphoid ce-ls from several sources, also failed repeatedly. Also, constitutively overexpression of Hsp70 is insufficient to effectively influence cell death after global cerebral ischemia in the mouse. This study demonstrates that detailed vascular information in the mouse brain can be obtained by using CE-SWI and is substantially enhanced compared to native SWI (i.e. This review discussed the immunomodulatory role of toxic heavy metal lead, on autoimmunity, phenotypic expression of the immune cells and hypersensitivity. Valsartan could also attenuate TF expression at mRNA level in VSMC treated by ox-LDL. Multi-contrast light profile microscopy for the depth-resolved imaging of the properties of multi-ply thin films.

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The TRF2 DNA-binding domain (TRF2 DBD) neutralized more negative charge on the surface of nucleosomal arrays than histone-free DNA. Recent literature points to the relevance of conducting a functional analysis of prefrontal subregions and supports the idea that the area of the medial prefrontal cortex in rats is characterized by its own functional heterogeneity, which may be related to neuroanatomical and neurochemical dissociations. Cyanobacteria are intricately organized, incorporating an array of internal thylakoid membranes, the site of photosynthesis, into cells no larger than other bacteria. The patterns of sensory enhancement seen in these data suggest a mechanism that may underlie the impairments in spatial attention that follow damage to parietal cortex, and help to specify the role of parietal cortex in spatial attention. Due to the failure of current therapeutics to improve outcomes in patients with pancreatic cancer, new therapeutic avenues targeting different components of the tumor microenvironment are being investigated. Compared to untreated NT2/D1 cells, RA treated cells have reduced proliferative potential. Critical Role of Transcription Factor PU.1 in the Function of the OX40L/TNFSF4 Promoter in Dendritic Cells. Herein, we show for the first time that cell transformation induced by Bcr-Abl leads to increased expression and kinase activity of MEK kinase 1 (MEKK1), which acts upstream of the c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase (ERK) and NF-kappaB signaling pathways. This is of potential interest for future neuroprotective trials. Colony-forming units were enumerated by spot plating on both nonselective (brain-heart infusion) and selective (Rogosa SL) agar.

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In some streptococci AI-2 is reported to be involved in virulence expression and biofilm formation. Evaluating the proximate determinants framework for HIV infection in rural Zimbabwe. This study aimed to compare the impact of pillow height on double-lumen tracheal tube (DLT) intubation with McGRATH MAC (McG) in patients undergoing elective surgery. Altogether, our findings indicate that the Rag2(-)Il2rb(-)Dmd(-) mouse represents an ideal model to gain further insights into the behavior of human myogenic stem cells in a dystrophic context, and can be used to assess innovative therapeutic strategies for muscular dystrophies. Delivering multiple growth factors in combination and sequence could aid in creating tissue engineered constructs and therapies aimed at promoting healing after acute wounds and in chronic conditions such as diabetic ulcers and peripheral artery disease. Variability of development in three siblings with fragile X syndrome. Magnetic resonance imaging demonstrated two intracerebral lesions. Their structures were elucidated on the basis of spectroscopic analyses. Through use of whole-exome sequencing, germline mutations were widely found that were associated with cancer development, including mutations in the BRCA1, DNA repair associated (BRCA1), BRCA2, tumor protein 53, erb-b2 receptor tyrosine kinase 2, matrix metalloproteinases and ADAM metallopeptidase domain-containing genes.

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Clinical studies suggest that plasma insulin levels may predict the extent of cardiovascular benefit achieved with weight loss in obese individuals, but mechanisms are currently unknown. Potential applications of gut microbiota to control human physiology. Therapy in larynx obstructing papillomatosis usually requires laser ablation. Our data provide an explanation for the in vitro and in vivo attenuation of cell culture adapted HCV genomes and may open new avenues for the development of fully competent culture systems covering the therapeutically most relevant HCV genotypes. All 6 patients underwent early surgical stabilization that allowed improvement in-hospital patient care and quick transfer to rehabilitation centers. How to teach medication management: a review of novel educational materials in geriatrics.

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