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Klonopin (Clonazepam)

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Klonopin is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Klonopin was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Anxrea, Clodep, Clonapax, Clonatrac, Clonax, Clonazepam, Clopam, Cloze, Clozep, Clozipam, Clozorix, Convaclon, Deptune, Easyfeel, Ection, Eminaz, Epcon, Epicloz, Epizam, Escimax, Escitapax, Esitor, Jasoclam, Meloprax, Nazee, Nexclo, Ozepam, Prasilex, Revozip, Sezolan, Sezolep, Somnolex, Somnotril, Ubitpam, Zeficar, Zozep

Similar Products:
Temovate, Propecia, Parlodel, Geodon, Ventolin, Persantine, Adipex, Xenical, Glucophage, Incez, Trendis, Cardyl, Esgred, Prichek, Albendol, Helmax, Lydin,

Also known as: Clonazepam


Klonopin (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Klonopin is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Klonopin is also used to treat panic disorder (including agoraphobia) in adults.


This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Klonopin Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.


Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using Klonopin. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

Tell your doctor if your condition persists or worsens.

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Experimental off-pump transventricular pulmonary valve replacement using a self-expandable valved stent: A new approach for pulmonary incompetence after repaired tetralogy of Fallot?. These proteins bound 125I-labeled PAI-2 in vitro (IC50, approximately 10-100 nM) in a calcium-independent reaction that did not abrogate the proteinase inhibitory function of PAI-2. While these systems were strongly expressed in the parent line and the neuroblast-like clones SH-SY5Y and SH-IN, they were absent or barely detectable in the nonneuronal EP clone. There are several limitations to the current CHIRPP system in Glasgow: it is not population based, only injuries presented to the accident and emergency department are included, and injury severity is not recorded. The mice were injected intraperitoneally with 500 mg/kg of 5-FC, or with 5, 15 or 30 mg/kg of 5-fluorouracil (5-FU), for 9 days. Many consider the Amazonian forest to be a medicinal treasure chest and potentially the largest drug dispensary in the world.

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We report two cases of transection of all three portal structures, one during an open right adrenalectomy and another during a laparoscopic cholecystectomy, both of which were transferred to our tertiary care center hours postinjury. Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. Arsenite resistance levels in wild-type cells could be accounted for by the contribution of PgpA alone. To report a case of hyperglycemia induced by megestrol acetate in a patient with AIDS. Multiple logistic regression analysis was used to determine the influence of family affluence on health behaviors and the strength of associations of general health behaviors in models for oral health behaviors. Metanephric adenoma of the kidney: ultrastructural, immunohistochemical and lectin histochemical studies. Successful data collection and quality control are also necessary. Physiological role of the opioid-cholinergic interaction in growth hormone neuroregulation: effect of sex and food intake. Furthermore, biochemical analysis indicated that NEDL2 appears to act like a scaffold protein to recruit SHC, Grb2, PI3K (p110 and p85), PDK1 and Akt together to promote the signaling transduction. The modified force field has been employed in the context of an integrated approach, based on classical molecular dynamics and discrete-continuum solvent models, for the investigation of environmental and short-time dynamic effects on the hyperfine and gyromagnetic tensors of PROXYL, TEMPO and INDCO spin probes.

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Mechanisms of calcification and molecular phylogeny of Rubisco genes in coccolithophorid algae. Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex. In contrast, the cocaine-insensitive site(s) have a low affinity for norepinephrine (apparent Km, approximately 88 microM) and are also able to transport catecholamine analogues such as dimethyl-epinephrine and isoproterenol, which have bulky groups attached to the amine moiety. The ongoing quandary in kidney transplantation is discovering methods to prolong graft survival. Obstructive jaundice from metastatic lung cancer is extremely rare. In addition to its effect on thymidylate synthase inhibition and DNA synthesis, 5-FU may also influence RNA metabolism. Further, we aim to determine the role of H2 receptor expression in BTB permeability, and elucidate the underlying mechanisms thereof. Some of these markers for alcohol consumption do not only indicate previous ethanol ingestion, but also approximate the amount of intake and the time when ethanol ingestion last occurred.

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Water drinking elicits an acute hemodynamic response and changes in cerebrovascular regulation in healthy subjects. Pathological examination revealed degenerated fibrocartilage which stained for amyloid. Many pharmaceuticals and personal care products (PPCPs) are commonly found in biosolids and effluents from wastewater treatment plants. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. A general method for the identification of these small molecule targets has not yet been established. Healthcare providers are challenged to support patients in dealing with this unresolvable dilemma. Further, age-related increases of astrogliosis were seen in the cortex and hippocampi of aged SAMP8 and SAMR1, as revealed by the expression of the astrocyte specific marker, glial fibrillary acidic protein (GFAP). Positron emission tomography and (15)O-water was used to measure regional cerebral blood flow in subjects with DSM-IV defined social phobia during anxiety anticipation. These patients should be continuously observed along with proper urinary management depending on the disease progression. Mutation of the Kex2p TLS results in transport of Kex2p to the vacuole by default.

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Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Prevention of indomethacin-induced acute gastric mucosal injury by spermine in the rat. In a membrane potential-dependent step the precursors insert into the inner membrane, adopt a characteristic topology and assemble with Tim23. Although randomized trials are needed, experiential nutrition education focusing on spices and herbs may help urban and predominantly African-American adolescent populations eat healthier diets. Toll-like receptors (TLRs) 7 and 8 are crucial in host defence against single-stranded RNA (ssRNA) viruses.

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In the in vivo experiments in the early treatment group, myocardial virus titers were higher in NG-nitro-L-arginine methyl ester-treated than infected untreated animals, and both inflammatory cell infiltration and necrosis were more severe. XrelA overexpression in the dorsal side of embryos reduces dorsal development and attenuates in vitro dorsal morphogenetic movements. The disease is often misdiagnosed and the subsequent delay in treatment results in worse outcomes. We evaluated the uptake of these EBCOG recommendations in guidelines for GDM screening across Europe. Thus, implantable cardioverter defibrillators (ICD) became the main therapeutic option in these patients. To determine the risk factors associated with progression from colonization to infection with health care-associated antimicrobial-nonsusceptible Enterobacteriaceae (ANE) in critically ill neonates.

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In order to prevent medical errors, it is important to know why they occur and to identify their causes. Calcimimetics overcome the stimulatory effect of high phosphate on PTH secretion in vivo and in vitro. No rebound was observed on the following day with all drug groups returning to normal activity and feeding regimes. hospitals, evidence-based fall prevention interventions targeted to patient-specific fall risk factors (Targeted Risk Factor Fall Prevention Bundle). To describe the consequences in terms of health outcomes, care and associated healthcare costs for three hypothetical cohorts of women planning their first pregnancy at a fixed, different age. Weak endemic states, in which the epidemics spreads when the two layers are interconnected but not in each layer separately, show a transition from the endemic to the healthy phase when the rewiring overcomes a threshold value that depends on the infection rate, the strength of the coupling and the mean connectivity of the networks. To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.

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Development of new anti-rheumatic drugs in Japan: present and future. However, some fractures will fail to unite, leaving the patient with an unstable, dysfunctional, and often painful upper extremity that requires additional surgery. In contrast, double-stranded (ds) DNA viruses feature a much broader diversity of DNA replication machineries. The present data suggest that individuals with WS produce appropriate prosodic cues to express contrast, although their use of pitch may be somewhat atypical. Finite element analysis indicated high stress levels below the load and at margins, in agreement with only single-cycle fracture origins. When cells were stimulated with cytokines, the release of isoprostanes was inhibited by the cyclooxygenase-1 and -2 inhibitor indomethacin as well by as the cyclooxygenase-2 selective inhibitor L-745,337. The use, effects and toxicity of caffeine intake are reviewed separately for different segments of the population.

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Even large intentional overdoses by adults seldom lead to serious morbidity. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. A large density cavity that measured 2000 km across and 500 km in height was observed by DEMETER and Formosat/COSMIC satellites in temporal and spatial relation to a new mode of propagation of electromagnetic (em) pulses between discrete magnetic field-aligned auroral plasmas to high altitudes. A 2-year aeroallergen survey and skin test (ST) results of 1,017 subjects were reviewed. Analysis of the flaps was performed using digital measurement and scintigraphy. Overnight starvation led to complete hepatic glycogen depletion, associated hypoketotic hypoglycemia, increased hepatocellular autophagy, and increased glycogen synthase levels in Par-1a(-/-) but not in control or Par-1b(-/-) mice. Pathophysiology and diagnosis of spontaneous intracranial hypotension. Accordingly, HNRNPH levels decline while TRF2-S levels increase during neuronal differentiation. Telbivudine is a new nucleoside analog indicated for the treatment of chronic hepatitis B infection.

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Derivation of extracellular polysaccharide-deficient variants from a serotype A strain of Pasteurella multocida. The characteristics and outcome of bacteraemia in renal transplant recipients and non-transplant renal patients. Study of CD44v6 protein expression in intraductal papilloma and its malignant transformation of breast. The dominant effect of many agents is the potentiation of the inhibitory neurotransmitter gamma amino butyric acid (GABA) by various mechanisms while inhibiting the effects of excitatory transmitters seems to be less dominant, except for ketamine. A continuous quality-improvement approach that engages all departments involved in patient care is necessary to achieve meaningful change in complicated hospital processes. Hence, the duration of angiotensin converting enzyme inhibition was considerably prolonged in renal failure and depended on the severity of renal impairment. Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae. Earthworm egg capsules (cocoons) may acquire bacteria from the environment in which they are produced.

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Effect of crown ether concentration, nitric acid concentration, plasticizer and CTA concentration on the transport rate of Cs was also studied. In this regard, general dental practitioners should at least reinforce their knowledge regarding obesity and understand their potential role in the treatment and management of obese patients. Morphologic aspects of colonies of isoniazid-resistant Mycobacterium tuberculosis. Data from the R-16 radiation dosimeter mounted to the outside of the Mir space station are analyzed to determine the radiation environment and absorbed radiation dose inside Mir during the 22nd solar cycle. cAMP-dependent phosphorylation of DARPP-32 is stimulated via activation of dopamine D1 receptors in striatonigral neurons, and via activation of adenosine A2A receptors in striatopallidal neurons. A new technique based on the Goldman-Shen pulse sequence with varying preparation interval is proposed for the study of domain morphology of segmented polyurethanes. Six skin biopsies have been performed with no conclusive histological diagnosis of any of the typical disorders of keratinization. Histopathologically, these structures were composed of numerous fine granules nortriptyline 50 mg generic and were generally located near the neuronal cell bodies. We describe a 13-day-old girl who developed seizures on day 1 of life and was placed on antiseizure medication. Utility of isotachophoresis-capillary zone electrophoresis, mass spectrometry and high-performance size-exclusion chromatography for monitoring of interleukin-6 dimer formation.

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As well as being of interest in its own right, the use of a minimum clinically important difference on the patient-reported outcome scale is likely to lead to sample size advantages. The metabolism of phosphoinositides was investigated in erythrocyte membranes of essential hypertensive patients, normotensive offspring of hypertensive patients and matched controls. Linoleic acid attenuates cardioprotection induced by resolvin D1. We show how the co-existence of trees and grasses in savannas can be simultaneously controlled by rainfall and fire, and how the relative importance of the two factors distinguishes between dry and moist savannas. In fact, in all cells with high levels of L protein expression, which at 40 h posttransfection represented almost the total number of transfected cells, viral replication not only of the temperature-sensitive mutant but also of wild-type VSV was excluded. The time of recurrence appears to impact survival more significantly than localization, but to date, guidelines for therapeutic management of recurrent HCC have not been established.

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Totally 120 HBeAg positive CHB patients who were treated with Peg-IFNalpha were enrolled, and assigned to YDS group (59 cases) and non-YDS group (61 cases) according to classification of CM constitutions. It is related to an autoimmune response to infection with group A streptococcus. To investigate late allergic reactions, including eosinophil inflammation, associated with outgrowing mite antigen-induced bronchial asthma during adolescence, the relationship between clinical status and functional activity of interleukin (IL)-5 produced by Dermatophagoides farinae (Df)-stimulated peripheral mononuclear cells (PBMCs) in culture was assessed in mouse IL-3-dependent cells transfected with the human IL-5 receptor gene. Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants. Early symptoms are broad and include depression, behavioural change, neurological disorders, systemic disorders and mild cognitive impairment (MCI). There are few studies of CNVs in patients with both ID and epilepsy. This suggests that the association is not due to greater diagnosis or perception of symptoms in obese people compared with those of normal weight. An investigation into the effects of silver nanoparticles on natural microbial communities in two freshwater sediments. Laryngeal echolocation, used by most living bats to form images of their surroundings and to detect and capture flying prey, is considered to be a key innovation for the evolutionary success of bats, and palaeontologists have long sought osteological correlates of echolocation that can be used to infer the behaviour of fossil bats. We report the impact on the patient management of two liver biopsies, which diagnosed an initial drug induced hepatitis and subsequently an atypical HCV related hepatitis.

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Placentas were then examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin. Vaccinia virus early transcription factor (VETF) is a heterodimeric protein that is packaged in virus particles for expression of early genes during the next round of infection. This result suggests that BMSC can transform into mature cells from stem cell phase. Results provide insight into the mode of action of HA as a therapeutic agent for arthritis and its stabilizing influence on cartilage metabolism. In addition to featuring a ladder of incremental protein-DNA complexes, the computed mobility-shift patterns placed emphasis upon stabilization of weak, nonspecific complexes in gel cages. Microtubules emanating from the nuclear membrane mainly ran along the longitudinal axis of cardiac myocytes in interphase. Renal cells and tubular lumens rapidly accumulated the rapamycin analog from the medium and attained steady state within 60 min. The health status of 133 solvent-exposed can claritin make you fail a drug test painters was evaluated using the Neurobehavioral Evaluation System (NES) and blood test results from a physical exam.

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One hundred and thirty three patients were given radiotherapy after subtotal resection of glioblastoma with different total doses and fractionation schedules including 38 patients receiving continuous accelerated fractionation with 3 fractions of 1.6 Gy per day up to 60 Gy in 2 weeks. The Ciidae (Coleoptera) of New Brunswick, Canada: New records and new synonyms. Circadian Metabolism: From Mechanisms to Metabolomics and anafranil 25 mg preço Medicine. nov., a new Vibrio species belonging to the Splendidus clade with pathogenic potential for clams. Ultimate vortex confinement studied by scanning tunneling spectroscopy.

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The gastric pathogen Helicobacter pylori is known to be able to use molecular hydrogen as a respiratory substrate when grown in the laboratory. Pre- and postdissection computer tomography (CT) scans assessed completeness of dissection. Diffuse diabetic macular edema is difficult to manage and frequently requires multiple therapies. However, after 120 h of activation, MNL concentrations in splenic what is generic zofran T cells were more than 3-fold higher than in thymic T cells. Mean first spike latencies, however, differed across PSTH groups, owing to the temporal definitions of these PSTH shapes.

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Chlorine dioxide test solution was infused into the chambers, and samples for microbial culture were collected throughout several months to evaluate microbial efficacy. Surprisingly, amethopterin Syk-phosphorylated Shc possesses two Grb2 binding sites rather than the one site that has been previously reported. Torticollis is a common clinical sign encountered by pediatricians in a wide variety of childhood illnesses including those from traumatic, neurologic, infectious, inflammatory, and psychogenic causes. FORUM: Bioregional Conflict Resolution: Rebuilding Community in Watershed Planning and Organizing. This complex process involves the coordinated actions of more than 20 polypeptides. In this study, we used UPOD to identify better biomarkers for discriminating different asthma phenotypes.

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The projection pattern in the diencephalic neuropils is related to the depth of the terminal arbor within the tectal fiber layer. Many examples of such contributions are presented in recent reviews of psychological research with animals. To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy. The control groups included 5 teeth each consisting of NaOCl (positive control) and distilled water (negative control). Pharmacological action of Acorus calamus, Curcuma zedoaria, Xanthoxylum alatum and Angelica archangelica. In diabetic rings with endothelium, both DETAPAC or SOD plus catalase increased sensitivity but not maximum relaxation to NTG. The most common adaptive filtering method is based on the least mean square (LMS) algorithm, which updates the filter coefficients by a gradient based method. These results suggest a role for glucocorticoids in the regulation of 5-lipoxygenase pathway expression in mononuclear phagocytes. This study investigated the use of ultraviolet-absorbing or photoprotective agents as a method of decreasing the color changes caused by ultraviolet radiation on an intrinsically tinted facial prosthetic material.

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