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Hydrea (Hydroxyurea)

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Hydrea works by blocking an enzyme (ribonucleotide reductase) which is required for synthesis of DNA. This prevents the cancer cells from growing and multiplying. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) levels in red blood cells (RBCs).

Other names for this medication:
Cytodrox, Droxia, Droxiget, Durea, Gindrea, Hondrea, Hydab, Hydroxyurea, Hytas, Myelostat, Neodrea, Oxyrea, Riborea, Urdox

Similar Products:
Ditropan, Thorazine, Colospa, Xeloda, Cordarone, Lodine, Effexor, Nolvadex, Oralcam, Zolpitrac, Somaspas, Mebrin, Carlon, Alrose, Anerozol,

Also known as: Hydroxyurea


Hydrea is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck).

Hydrea is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia. This medicine will not cure sickle cell anemia.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Hydrea is usually taken once per day at the same time of day, with or without food. Swallow the pill whole with a glass of water.

Wash your hands before and after you handle Hydrea or the bottle that contains the pills. For best protection, wear disposable gloves when handling the pills.

Do not open the Hydrea capsule or crush or chew a tablet. Do not use a broken pill. The medicine from a crushed or broken pill can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water.

If any powder from a broken pill is spilled, wipe it up at once with a damp paper towel and throw the towel away in a sealed plastic bag where children and pets cannot get to it.

Your doctor may also want you to take a folic acid supplement. Follow dosing instructions very carefully.

Hydrea can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Hydrea.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Detailed Hydrea dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, mouth sores, and swelling with pain and purple discoloration in your hands and feet.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Hydrea dosage information

Side effects

The most common side effects associated with Hydrea are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Hydrea if you are allergic to it.

Tell your doctor if you have ever had:

kidney disease (or if you are on dialysis); liver disease; a wound or ulcer on your leg; HIV or AIDS (especially if you take antiviral medicine); high levels of uric acid in your blood; or treatment with an interferon, chemotherapy, or radiation.

Using Hydrea may increase your risk of developing other types cancer or leukemia. Talk with your doctor about your specific risk.

Hydrea can harm an unborn baby. Both men and women using this medicine should use birth control to prevent pregnancy. The use of this medicine by either parent may cause birth defects.

If you are a woman, keep using birth control for at least 6 months after your last dose of Hydrea. If you are a man, keep using birth control for at least 1 year after your last dose (6 months if you took Siklos). Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control because Hydrea may harm the baby if a pregnancy does occur.

You should not breastfeed while you are taking Hydrea.

Older adults may be more sensitive to the effects of this medicine.

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