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Fasigyn (Tinidazole)
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Fasigyn

Fasigyn is an antibiotic, which belongs to a group of medicines called nitroimidazoles. Fasigyn works by killing or stopping the growth of bacteria causing your infection. Fasigyn will not work against viral infections such as colds or flu.

Other names for this medication:
Simplotan, Tindamax, Tinidazole

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Also known as: Tinidazole

Description

Fasigyn 500mg film-coated tablets contain 500mg of the active substance tinidazole. This medicine is an anti-infective agent. It is used to treat a variety of bacterial infections including: infections of the skin, blood, chest, lung, genitals or womb lining, an infection associated with stomach ulcers in combination with other drugs, infections caused by organisms called protozoa, such as amoebiasis and giardiasis (stomach infections) and trichomoniasis (a genital infection), vaginal infections (vaginitis) and gum infections (gingivitis).

It is also used before certain surgical operations to prevent bacterial infections developing.

You should ask your doctor if you are unsure why you have been given this medicine.

Dosage

Fasigyn tablets should be taken with plenty of water with or after meal. Swallow Fasigyn tablets whole, do not chew or crush. Fasigyn is not recommended for use in children less than 12 years. For urogenital Trichomoniasis: The recommended dose is 4 tablets (2 g) given as a single dose. For amoebic involvement of the liver (a liver infection): the recommended dose is 3 to 4 tablets (1,5 to 2 g) once a day for 3 to 6 days. For the infection associated with stomach ulcers: the recommended dose is 1 tablet (500 mg) taken twice a day. For most bacterial infections: the recommended dose is 4 tablets (2 g) on the first day then 2 tablets (1 g) once a day or 1 tablet (500 mg) twice a day. The usual length of treatment is 5 to 6 days. For bacterial vaginitis (a vaginal infection) and acute ulcerative gingivitis (a gum infection): the recommended dose is 4 tablets (2 g) given as a single dose. For vaginitis you may be given 4 tablets (2 g) on two consecutive days. For protozoal infections (intestinal amoebiasis): the recommended dose is 4 tablets (2 g) once a day for 2 to 3 days. Prevention of postoperative infections in adults (over 12 years): the recommended oral dose of 2 g approximately 12 hours before surgery.

Overdose

Immediately telephone your doctor or go to Accident and Emergency (Casualty) at your nearest hospital if you think you or anyone else may have taken too much Fasigyn. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Keep telephone numbers of these places handy.

If you take too many tablets, you may get an upset stomach, diarrhoea or skin rashes.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Fasigyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

As with other drugs of similar structure, tinidazole is contraindicated in patients having, or with a history of, blood dyscrasia, although no persistent haematological abnormalities have been noted in clinical or animal studies.

Tinidazole should be avoided in patients with organic neurological disorders.

Tinidazole, other 5-nitroimidazole derivatives or any of the components of this product should not be administered to patients with known hypersensitivity to the drug.

Use of tinidazole is contraindicated during the first trimester of pregnancy and in nursing mothers

As with related compounds, alcoholic beverages should be avoided during Fasigyn therapy because of the possibility of a disulfiram-like reaction (flushing, abdominal cramps, vomiting, tachycardia). Alcohol should be avoided until 72 hours after discontinuing Fasigyn.

Drugs of similar chemical structure have also produced various neurological disturbances such as dizziness, vertigo, incoordination and ataxia. If during therapy with Fasigyn abnormal neurological signs develop, therapy should be discontinued.

Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent. Although carcinogenicity data is not available for tinidazole, the two drugs are structurally related and therefore there is a potential for similar biologic effects. Mutagenicity results with tinidazole were mixed (positive and negative). The use of tinidazole for longer treatment than usually required should be carefully considered.

Alcohol: Concurrent use of tinidazole and alcohol may produce a disulfiram-like reaction and should be avoided.

Anticoagulants: Drugs of similar chemical structure have been shown to potentiate the effects of oral anticoagulants. Prothrombin time should be closely monitored and adjustments to the dose of the anticoagulants should be made as necessary.

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Field cycling NMR and conventional pulsed NMR techniques were employed to cover a frequency range of 100 kHz to 50 MHz. Mechanical stimulation of neurites generates an inward current in putative aortic baroreceptor neurons in vitro. In future, it might be useful in detecting abnormalities in speech discrimination profiles of children with possible language-related disorders. Location of divalent ion sites in acyl carrier protein using relaxation perturbed 2D NMR. Retrospective comparison of external beam radiotherapy and radical prostatectomy in high-risk, clinically localized prostate cancer.

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Absence of training-specific cardiac adaptation in paraplegic athletes. Parathyroid 99mTc-sestamibi scintigraphy: dual-tracer subtraction is superior to double-phase washout. In this study we devise a peptide inhibitor screening strategy to target the GEF activity of Tgat, an oncogenic isoform of the RhoGEF Trio, based on random mutations of the Trio inhibitor TRIP alpha, which we previously isolated using a peptide aptamer screen. One hundred and sixteen Jordanian male nursing students aged 18-24 years were divided into 4 groups according to parental history of T2DM and BMI. A 54-year-old woman was diagnosed as having septicemia secondary to infective endocarditis with aortic regurgitation which was complicated by endophthalmitis. By the use of discriminating and attributing analyses, one can as a rule arrive at a definite answer by using only one test. A multi-stage stratified random cluster sampling method was adopted to identify 29 township hospitals from six counties in three provinces. The sera of 42 subjects, representing an unselected group of patients from a single center, with juvenile DM and 7 others with idiopathic inflammatory myopathy (IIM) were examined for the presence of myositis specific antibodies by immunodiffusion against calf thymus extract and immunoprecipitation with HeLa extract. This article presents the various forms of bone grafts, along with their applications in foot and ankle surgery.

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Visible-Light-Driven Selective Photocatalytic Hydrogenation of Cinnamaldehyde over Au/SiC Catalysts. Adenoma of the middle ear is a rare tumor, which is developed from the tympanic cavity. The appropriate fusion gene was incorporated into a retroviral gene transfer vector. This model system holds great promise for helping tease apart the complicated network of genes that maintain a proper energy balance. However, when the challenge was carried out in the inner face of the ear with a small parasitic load, the association of plasmids encoding to IL-12 and GMC-SF to DNA based vaccination, the protective effects were increased. Automatic well counting results showed increased radioactivity in the SK-BR3 xenograft tumors.

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Quantitative analysis of clinical dynamic contrast-enhanced MR imaging for evaluating treatment response in human breast cancer. Fast bistable intensive light scattering in helix-free ferroelectric liquid crystals. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative 15O-PET imaging. Levels of the chemokines CX3CL1, CCL5, CCL2, CXCL12 and CXCL1 were measured in bone marrow plasma by specific ELISAs. The inhibition of VRAC by PE was antagonized by intracellular excess phosphatidylinositol 4,5-bisphosphate (PIP(2)), while intracellular anti-PIP(2) antibody (PIP(2) Ab) inhibited the activation of VRAC currents.

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Sensitization to cat allergen is common among young asthmatic patients in Japan, even among patients who do not keep cats. The aim of this study is to provide long-term data on the effectiveness and safety of olanzapine in a group of patients with severe refractory schizophrenia. The aim of this study was to compare the neuroregenerative capacity of preeclampsia-placenta stem cells to previously characterized placentas from uncomplicated pregnancies. This suggests that isoforms of MHC cost of micardis 40 mg have different characteristics necessary for defining specific muscle properties. Three ceased demonstrating aggressive behavior within 4-6 weeks after starting trazodone treatment.

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Mutagenic activity of structurally related oxiranes and siloranes in Salmonella typhimurium. A multivariate Cox regression model was used to predict BC metastases on the basis of patient characteristics and glucose-lowering medication. This single-centre study included all patients with cirrhosis who underwent PSE and CFF in 2011. Those PBGS with the aspartate-rich metal switch sequence contain Lys in the analogous position. The relative importance of serial HBV DNA measurements, the loss of hepatitis B e and surface antigens, as well as the emergence of HBV mutants in the progression of chronic hepatitis B, especially in young patients, is an important need for future research. An overview of some aspects of the current situation in Brazil, as regards environmental and human contamination by chemicals is presented. The time to complete emptying of water was used as a surrogate measure of gastric emptying. The ability of autograft alone and autograft combined with a radiolucent biomaterial composed of resorbable osteoconductive poly(lactide-co-glycolide) with entangled hyaluronic acid to facilitate fusion was examined in a single-level noninstrumented posterolateral intertransverse lumbar fusion model in New Zealand White rabbits. Reconciliation between experiments and theory is achieved when this bimodal spectrum is considered. Lowering cAMP concentrations in the culture media led to a decrease in the initial rates of L-citrulline uptake.

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Deriving Requirements for Pervasive Well-Being Technology From Work Stress and Intervention Theory: Framework and Case Study. CD3-specific antibody-induced T-cell apoptosis and apoptotic cell uptake lead to CD3-specific antibody-induced tolerance. beta-Adrenergic blockers were least likely to be administered regardless of age, gender, or cognitive or physical function. Our results suggest that clinicopathological factors predicting non-SLN involvement in SLN-positive patients with and without NAC are essentially the same. Emotion processing deficits in the different dimensions of psychometric schizotypy. This is of a particular concern in a health care system that is caring for a growing Aboriginal population. These parallel projections may be the basis for the variability seen in the behaviour.

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