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Dumozol (Metronidazole)
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Dumozol

Dumozol is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Aldezol, Amobin, Anaeromet, Anamet, Asuzol, Colpofilin, Corsagyl, Deprocid, Dequazol, Elyzol, Emedal, Farnat, Fladystin, Flagicure, Flagystatin, Flagystatine, Florazole, Geloderm, Grinazole, Gynomix, Imizine, Klion, Menizol, Metazol, Metrin, Metris, Metronidazole, Metronour, Metrosa, Metrozin, Metrozine, Micogyl, Minegyl, Missilor, Monizole, Mtronidazole, Nidagyl, Nidazea, Norzol, Onida, Orvagil, Otrozol, Pharmaflex, Robaz, Rosaced, Suanatem, Supplin, Torgyl, Trichostatic, Tricofin

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Also known as: Metronidazole

Description

Metronidazole vaginal is used to treat women with vaginal infections (eg, bacterial vaginosis).

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing the bacteria or preventing their growth. However, this medicine will not work for vaginal fungus or yeast infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Dumozol. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine is to be used only in the vagina. Use it at bedtime, unless your doctor tells you otherwise.

Do not get it into your eyes, nose, mouth, or skin. If this medicine does get into your eyes, wash them out right away with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

Nuvessa™ is available inside a prefilled applicator. The applicator is open at one end where you will insert the plunger and has a pink cap on the other end where the medicine will come out.

Vandazole® is in a tube. You will use an applicator to put the gel into your vagina. The applicator has a plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.

To use the medicine:

To fill the applicator: For cream or gel dosage forms: Nuvessa™: With the pink cap still on, push the tip of the plunger into the open end of the prefilled applicator. Pull the cap off before you insert the applicator into your vagina. Vandazole®: Break the metal seal at the opening of the tube by using the point on the top of the cap. Screw the applicator onto the tube. Squeeze the medicine into the applicator slowly until it is full. Remove the applicator from the tube. Replace the cap on the tube. For vaginal tablet dosage form: Place the vaginal tablet into the applicator. Wet the vaginal tablet with water for a few seconds. To insert vaginal metronidazole using the applicator: For all dosage forms: Relax while lying on your back with your knees bent (or in any position that you feel comfortable). Hold the full applicator in one hand. Insert it slowly into the vagina. Stop before it becomes uncomfortable. Slowly press the plunger until it stops. Withdraw the applicator. The medicine will be left behind in the vagina. Remove the applicator from your vagina. Use each applicator only once, and then throw it away.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. Also, continue using this medicine even if your menstrual period starts during the time of treatment.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bacterial vaginal infections: For vaginal dosage form (cream): Adults—One applicatorful (500 milligrams [mg]), inserted into the vagina. Use the medicine 1 or 2 times a day for 10 or 20 days. Children—Use and dose must be determined by your doctor. For vaginal dosage form (gel): Nuvessa™: Adults and children 12 years of age and older—One applicatorful (5 grams [g]) inserted into the vagina once (at bedtime). Each applicatorful of Nuvessa™ contains 65 mg of metronidazole. Children younger than 12 years of age—Use and dose must be determined by your doctor. Vandazole®: Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina. Use the medicine once a day in the evening for 10 or 20 days. Children—Use and dose must be determined by your doctor.

Overdose

Single oral doses of Dumozol, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Dumozol has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Dumozol overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Dumozol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Keratin immobilized on silica as a new stationary phase for chromatographic modelling of skin permeation. To test whether the structure of a protein is determined in a manner akin to the assembly of a jigsaw puzzle, up to 10 adjacent residues within the core of T4 lysozyme were replaced by methionine. Secretion of the proinflammatory cytokines, IL-2 and IFN-gamma, were lowest in the group fed 20 mg. Besides the core of published information on the subject, there is ongoing interest and a comparison of experiences occurring at meetings such as those of the AABB and state organizations such as the California Blood Bank Society. intracellularis live attenuated vaccine strain (10 pigs) or sham inoculum (4 pigs). Results of this study lend support to the traditional use of grapefruit seeds in the management of type 1 diabetic patients and may suggest a role in orthodox management of the disease.

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Reestablishment of the blood supply after 10 min ischemia was accompanied by significantly increased levels of thiobarbituric acid reactive substances (TBA-RS) after 10 and 30 min of reperfusion. In Drosophila, groucho is one of the neurogenic genes that participates in the Notch signalling pathway. To further investigate the osteogenic potential of rabbit marrow stromal stem cells cultured in vitro. Biomaterials modulate interleukin-8 and other inflammatory proteins during reepithelialization in cutaneous partial-thickness wounds in pigs. The results showed little longterm value of surgical synovectomy in the general treatment of RA or in the prevention of recurrences of disease activity or progressive articular damage. Furthermore, ADX rats drinking sucrose have normal corticotropin-releasing factor (CRF) mRNA throughout brain. Screening of infants for hyperbilirubinemia to prevent chronic bilirubin encephalopathy. GABAC receptor binding of quantum-dot conjugates of variable ligand valency. A redescription of Culicoides griseidorsum Kieffer, 1918, with comments on subgeneric position of some European taxa (Diptera: Ceratopogonidae). Anti-GP2 IgA can be hypothesised as a novel marker in large bile duct diseases.

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MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Individuals varied considerably in their pattern of Vbeta expression, but several significant differences were noted in the PBC group. Case studies of national, regional, and international diagnostic networks are presented. A new technique for solid-phase microextraction (SPME) of analytes using a helical solid sorbent followed by thermal desorption into a gas chromatographic injector is reported. To assess the efficacy and toxicity of repeated single 24-hour infusion of low-dose 5-fluorouracil for symptomatic hormone-refractory prostate cancer using relevant endpoints of palliation and biological response.

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Acceptability of a personally controlled health record in a community-based setting: implications for policy and design. The enhanced visible light photocatalytic activity of C-N-S-tridoped TiO(2) nanocrystals was explained on the basis of characterizations. RAP2B may be a novel candidate oncogene that plays important roles in carcinogenesis through activation of NF-kappaB pathway. The suppressor properties of exogenous TGF-beta 1 (0.5 ng/ml) on IgG2b production by LN B cells were also seen when testing IgG1 or IgG2a induced by interleukin-4 or interferon-gama, respectively. In the second experiment, LN were sequentially analysed in two groups of animals receiving i.v. Five drug models were mixed with microcrystalline cellulose and with three different ratios of water and extruded at two different speeds using a ram extruder. Reduced expression of FADS1 suggests pessimistic prognosis for NSCLC patients. These observations indicate that enhanced NO production is likely to be an important factor responsible for pathological insult of the cochlea. Here we measure the persistence of Z-DNA at these three sites under the influence of various metabolic inhibitors. Because of the high false-negative rate, benign FNABs require close follow-up with ultrasound examination and periodic biopsies.

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The relationship between sensory input and protective or damaging muscle activity has glucophage prices been minimally evaluated in the setting of OA. To develop and apply search filters retrieving the scientific output (SO) after 2000 focusing on Public Health (PH) of the new European Union (EU) Member States after the 2004 and 2007 enlargements. This imbalance causes rapidly a cascade of biochemical and metabolic events which, when the ischemia is particularly severe and extended, may lead, at the end, to tissue necrosis. Brain-gut induction of heat shock protein (HSP) 70 mRNA by psychophysiological stress in rats. More importantly, other studies consistently provide evidence that participation in regular physical activity among persons with selected impairments and disabilities results in improved functional status and quality of life.

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The presence of flow, reflux, and compressibility of 1394 vein segments in 82 patients was assessed by ultram gel means of duplex scanning. Lack of association of angiotensin-converting enzyme (DD/II) and angiotensinogen M235T gene polymorphism with renal function among Chinese patients with type II diabetes. We describe a sensitive, reliable, and convenient procedure to assay cell adhesion based on flow cytometry which allows quantitative studies of all major peripheral blood leukocytes adhering to microvascular endothelial cells. We transfected the luciferase gene driven by these three promoters into 14 cell lines of many tissues and several species. Moreover, its dominant role brings into question many interpretations of priming during speeded classification tasks in terms of perceptual-conceptual processing. For different system settings the estimated parameters showed a good agreement with the acoustical properties of the phantoms.

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