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Cosdol (Tramadol)

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Cosdol is used to relieve moderate to moderately severe pain. Cosdol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Acuvin, Adamon, Bludol, Damol, Doleira, Dolodol, Doltel, Domadol, Euphodol, Ibudol, Moludol, Muzox, Ospidol, Pacadon, Relidol, Siatram, Simol, Spasteez, Tamody, Taxidol, Traiz, Tramadol, Tramafen, Tramaflam, Tramagesic, Tramazac, Tramest, Tramot, Transic, Ultraspas

Similar Products:
Imuran, Benemid, Keflex, Avapro, Pyridium, Plaquenil, Indocin, Cycrin, Floxin, Lamepil, Encardil, Postadol, Cefakind, Fledore, Noritate,

Also known as: Tramadol


Cosdol ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Cosdol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Cosdol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Cosdol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed EC-Cosdol dosage information

Side effects

The most common side effects associated with Cosdol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Cosdol ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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A randomized controlled trial suggested a sample size of 91 patients. In this review, we describe these three main prototypes and discuss the most important technical modifications of each type, as well as donor and recipient procedures, and highlight the more recent operative technical topics of discussion in the literature. Positron emission tomography (PET) was used to locate an area in human extrastriate cortex that subserves a specific component process of visual object recognition. Of these, 2/3 had the normal content of circulating thyroid and thyrotropic hormones in the blood serum. However, in transplant patients the magnitude of resorption is greater, and bone volume tends to decrease rather than increase. Up to now no visual field loss was detectable by computerized perimetry (Octopus G1). In most cases, FXI protein is reduced in plasma, and examples of dysfunctional circulating FXI variants are rare. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome.

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This is the first case of opioid peptides containing a two-residue message domain and of opioid dipeptides with substantial opioid activity. The complex prognostic assessment provides a more solid basis for early therapeutic stratification. In conclusion, DBS collection during HIV point-of-care testing enables screening and confirmation of HBV, HCV and HIV infections. Collectively, these results indicated that the combination of tanshinone II A and cisplatin had a better treatment effect in vitro not only on androgen-dependent LNCaP cells but also on androgen-independent PC3 cells. Eighty-six children were consecutively evaluated using the parent report version of the Behavior Assessment System for Children during visits to a multidisciplinary urology clinic. The effects were proportional to visually determined cell destruction and independent of obvious culture artifacts. Inclusion of olanzapine is of benefit for pharmacological treatment of patients with bipolar disorder. Even fruits and vegetables kept under refrigeration can be spoiled by Alternaria species because the mold grows at low temperatures. In rings precontracted with phenylephrine (0.1 microM), pentoxifylline (10 nM-10 microM) induced concentration-dependent relaxations which were not modified after incubation with indomethacin (3 microM) but which were almost completely abolished after incubation with methylene blue (10 microM) or after mechanical removal of the endothelium. The following study investigated modes of failure leading to reoperation in this group of technically challenging patients.

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Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14. Surface parameters and profiles were measured before and after testing. Mutants affecting histidine utilization in Aspergillus nidulans. Prospective evaluation of three point of care devices for glycemia measurement in a neonatal intensive care unit. Two strains of an undescribed Pichia species were recovered from soil. In CRES-T, overexpression of a chimeric repressor, composed of the coding sequence of a transcription factor (TF) and short peptide designated as the repression domain, could interfere with the action of endogenous TF in plants. To confirm these findings, we expressed recombinant legumain in Escherichia coli and verified that recombinant legumain also functions as a potent antigen against the sera of clonorchiasis patients. We isolate AtCAMTA5, which binds to the 38-bp pollen-specific cis-acting region, by one-hybrid screening using the cis-acting region as a probe. Cardiac micro-vascular endothelial cells (CMECs) are important participants in myocardial angiogenesis processes.

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These results are consistent with the hypothesis that age-related impairments in goal maintenance abilities cause a compensatory shift in older adults from a proactive (seen in young adults) to a reactive cognitive control strategy. When broken down by risk status, the Low and Medium Risk Groups were statistically superior to the High Risk Group on cognitive measures. In contrast, species-specific, process-based predictions remain scarce at the continental scale. Adjusted indirect comparisons were then made between BRV and the other three AEDs using the obtained results, comparing the minimum and the highest effective recommended daily dose of each drug. We report ultrasonographic features of interstitial pregnancy and propose three magnetic resonance imaging criteria for the interstitial pregnancy localization. Aqueous flare following penetrating keratoplasty and in corneal graft rejection.

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All LHIN4 surgeons who provide colorectal cancer surgery were invited to an October 2006 inaugural QICC-L4 workshop and subsequent workshops in 2008, 2010, and 2012. Kounis syndrome is a pan-arterial anaphylaxis -associated syndrome affecting patients of any age, involving numerous and continuously increasing causes, with broadening clinical manifestations and covering a wide spectrum of mast cell activation disorders. In certain focal, mainly in generalised dystonias BoNT may not be sufficient or appropriate. Understanding how Shp2 and other PTPs contribute to oncogenesis should provide new insights into pathogenesis and might suggest new targets for anti-neoplastic drugs. The higher loading dose was associated with more rapid and satisfactory remission. Fluorescence of T-, HMW- and LMW-AGE and concentration of T-, HMW- and LMW-AOPP were measured after incubation with these substances.

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Academic performance in the spring of first grade mediated the relationship between inattention in fall of first grade and depressive symptoms in spring of 3rd grade. Following the introduction of the DNA hybridization technique several genotypes have been separated from the older phenotypically described Aeromonas species. In the psychiatric clinic, delirious states are rare as the first symptoms of paraneoplastic syndrome, and the aetiology can only be clarified by consequent differential diagnostic efforts. In vivo stable tumor-specific painting in various colors using dehalogenase-based protein-tag fluorescent ligands. Spatial attention and the latency of neuronal responses in macaque area V4. Historical overview of REM sleep behavior disorder in relation to its pathophysiology. Contrary to previous reports, we did not observe over-transmission of the common Val66 allele, from either parent to affected children. These findings also provide cues for future studies on species interaction, as well as for the assessment of a monitoring scheme which may help interpreting the effects of broad environmental changes. Insulin induction of acetyl-CoA carboxylase (ACC) and differentiation of 30A5 preadipocytes into adipocytes requires a brief exposure of the cells to cAMP.

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Perigestational dietary folic acid deficiency protects against medulloblastoma formation in a mouse model of nevoid basal cell carcinoma syndrome. Continuous polyelectrolyte adsorption under an applied electric potential. Furthermore, FZD treatment resulted in increased stability of tumor suppressor p53 protein in AML cells. Multi-wavelength source using low drive-voltage amplitude modulators for optical communications. Evaluation of ofloxacin penetration into the skin after a single oral dose assessed by cutaneous microdialysis. Treatment of children with congenital clefts of hard and soft palate by floating obturator. However, overexpression of Id-1 in a p53 mutated cell line, CNE1, was able to suppress PARP cleavage in response to all anticancer drugs examined. DSI is a promising computer-assisted biomarker approach for aiding in the diagnostic process of dementing diseases.

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Blood and urine samples were collected during the following 24-h study period. The sensitivity, specificity, and diagnostic odds ratios (DORs) were calculated for each study, and the study quality and heterogeneity among the studies were evaluated. We found that all 13 of the Populus NP-like genes belonging to either Group I or II are expressed in various tissues in both LD and SD conditions. Muscadine grapes contain unique phytochemical constituents compared with other grapes and are potentially a source for novel compounds with antitumor activities. With the proposed weights, we can use the dogs motrin dosage marginal structural models as a useful tool for the nonparametric multivariate standardization. Gastrointestinal symptoms, in addition to constitutional and respiratory symptoms, were common. The protein levels of poly (ADP-ribose) polymerase (PARP) and caspases were determined by Western blotting.

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Two hours later, each participant received either 1 unit of 2-day stored (2D) autologous RBCs, 35-day stored (35D) autologous RBCs, or an equal volume of saline. Characterization of a molluscum contagiosum virus homolog of the vaccinia virus p37K major envelope antigen. A within-subjects design was used to compare the performance of children and adolescents with AN on several neuropsychological measures administered before and after a course of CRT. The results of a Bartlett Sphericity test suggest that each odorant produces an independent pattern of responses across units. The famvir drug side effects periodontal pathogen, Actinobacillus actinomycetemcomitans, produces a 116-kDa leukotoxin that appears to help the bacterium evade the innate host immune response. Continuous fixed-bed studies were undertaken to evaluate the efficiency of jackfruit leaf powder (JLP) as an adsorbent for the removal of methylene blue (MB) from aqueous solution under the effect of various process parameters like bed depth (5-10cm), flow rate (30-50mL/min) and initial MB concentrations (100-300mg/L). Because all of these electrophysiological studies have been performed in rodent brain slice or neuronal culture preparations, direct evidence that ethanol exerts similar effects on synaptic transmission in the primate central nervous system is lacking. Knowledge, access and usage pattern of HINARI by researchers and clinicians in tertiary health institutions in south-west Nigeria. Use of recombinant inbred strains to detect quantitative trait loci associated with behavior.

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It seems to us that IFN oral therapy may improve the tolerance of chemotherapy and radiotherapy. Currently, little is known concerning the functions of these receptors during development. As logic becomes more complex and applications narrower, the increased number of unique circuit designs needed tends to increase costs. This reduces both oxygen demand and local metabolite production, lowering the level of angina. Minocycline-induced hyperpigmentation (MIH) is a well-recognized phenomenon documented to involve a wide array of anatomic locations including the skin how many hours after taking zyrtec can i drink alcohol and nails, the sclera and conjunctiva, the oral cavity, and the skeleton and cartilage, as well as within viscera and body fluids.

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Boys and girls from low socio-economic neighbourhoods reported lower participation diflucan 200 mg capsules in sports/exercise compared to those living in higher socio-economic neighbourhoods. Synergistic effects of Lactobacillus rhamnosus ZDY114 and bovine colostrums on the immunological function of mouse in vivo and in vitro. New chromogens for alkaline phosphatase histochemistry: salmon and magenta phosphate are useful for single- and double-label immunohistochemistry. A column of aldehyde-activated silica was used to prepare a column specific to carbofuran. This study demonstrates a good agreement between the pulmonary and systemic blood flow measurements using dual beam Doppler ultrasound in babies.

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Twenty patients with high-signal abnormalities in the hippocampus on the initial DWI underwent subsequent DWI and T2-weighted imaging in the coronal plane to precisely localize the lesions. qualitative assessment using semi-structured in-depth interviews (IDIs) and focus group discussions (FGDs). Neuroleptic-induced dysphoric response in non-schizophrenic patients. The reconstruction of the extensive lip defects after surgical resection of tumors is challenging. To analyze clinical manifestations, surgical findings, and postoperative functional results of petrous apex cholesteatoma. The presented case evaluates the treatment of an alveolar fracture associated with mandibular immature lower permanent incisors. This activity conformed to Michaelis-Menten kinetics but was unresponsive to substrates or accessory proteins. Legislation of a case management service provided an opportunity to conduct a natural experiment exploring questions about implementation and effectiveness of case management services. Here, we demonstrate that two ZNF-265 transcript isoforms are expressed in various mouse tissues and that ZNF265-1 is a major isoform. Finally, Epo promoted cell migration of MV3 cells, whereas inhibition of the JAK/STAT and ERK1/2 pathways reduced Epo-mediated migration.

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The first to be discovered was the hyperplastic polyp, which is still the most commonly encountered serrated polyp. The effect of lattice spacing change on cross-bridge kinetics in rabbit psoas fibers. Alfa-fetoprotein (AFP) levels were normalized within the first year of therapy. On the delayed self-heterodyne interferometric technique for determining the linewidth of fiber lasers. We have isolated partial cDNAs from wheat (Triticum aestivum) using the polymerase chain reaction. Anaphylaxis is a life-threatening emergency of which reliable epidemiological data are lacking. This HMGI-C protein was found to be modified by phosphorylation, part of which was found to be phosphatase insensitive. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Treatment with sodium arsenate for 30-120 min led to assembling of stress granules in a majority of CV-1 cells.

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Describe the usage patterns of serum mexiletine concentrations and the impact of these concentrations on mexiletine dosing in modern practice for ventricular arrhythmia treatment. During the Galileo flyby of Venus the plasma wave instrument was used to search for impulsive radio signals from lightning and to investigate locally generated plasma waves. Quantum yields for the disappearance of 1a in water and 2-propanol were determined. After incubation for 5 hours, the cells were fixed, permeablized and stained with multiplecolor-labeled mAbs for cell surface and intracellular cytokines. Varicocelectomy is the most commonly performed operative procedure for varicocele. This review summarizes some of the key recently published patents and relevant research advances on miRNA target identification, strategies to modulate their activity and the potential applications in human diseases such as cancer and viral infections, as well as methods and techniques for purification, detection and quantification of miRNAs.

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