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Carcal (Calcitriol)
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Carcal

Carcal is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Alfacal, Alfacalcirol, Alfarich, Apcical, Arcium, Biocal, Biocitral, Bonetuf, Calbory, Calcicare, Calcimet, Calcirol, Calcor, Calday, Caldikind, Calfa, Calotec, Caltin, Calvical, Carcal, Devita, Dmcal, Duracal, Kurecal, Minroset, Nutribone, Osteobel, Ostonex, Qpcal, Refirm, Riecal, Roical, Rolsical, Sorvate, Statbone, Sunmic, Tobalt, Vezocal, Zaxial

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Also known as: Calcitriol

Description

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.

Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of vitamin D used in vitamin supplements.

Some conditions may increase your need for vitamin D. These include:

Alcoholism Intestine diseases Kidney disease Liver disease Overactivity of the parathyroid glands with kidney failure Pancreas disease Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.

Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Carcal. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Carcal and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Carcal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

If you are taking a dietary supplement without a prescription, carefully read and follow any precautions on the label. For these supplements, the following should be considered:

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We present the case of a 25-year-old woman with the initials S.K. The impact of psychological factors is often taken into account in the evaluation of quality of life. In sum, only depressive symptoms negatively predicted subsequent exercise frequency (Follow-up 1 and Follow-up 2). Robotic-assisted surgery is one of the latest innovations in the field of minimally invasive surgery. The present findings provide further evidence that lysozyme has an important role in the defence of the host against micro-organisms, and the findings suggest that lysozyme may reach its target by several routes. Survey of perceived stress-inducing problems among dental students, Saudi Arabia. The relative stability of Treg cells at inflammatory disease sites has been a highly contentious subject.

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Acute effects of neuroleptics on unmedicated schizophrenic patients and controls. It is applicable in the fields of homoepathy and allopathy, however, there are many different ways of treatment. Increased patient loads, resulting in increased frequency of nursing tasks and non-nursing tasks, were positively correlated to incompletion of nursing activities during the shift. Possible experiments to verify the axial segregation are discussed. Observing the coaching interview was valuable for the treating physiotherapists in that it provided a way to refocus, step back, gain insight, and facilitate more active involvement for their patients in the rehabilitation process. In recent years, MDSCs have also been found in non-cancer settings, including a number of viral infections. Effect of Intraoperative Peritoneal Irrigation of Xylocaine on Small and Large Bowel Activity. The vaccine-bait proved unstable when held at 4 C or 25 C for 96 hours prior to feeding. Breaking of the selection rules for optical transitions in the dielectric PrFe3(BO3)4 crystal by a praseodymium-iron exchange interaction.

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In the quail troponin-I gene, it is known that the entire troponin-C-binding domain is encoded by a single exon. It is the first protein described to bind both to the 26 S proteasome and to proteins in other complexes containing cyclin-dependent kinase(s) and p53 ubiquitylating activities, thus providing a mechanism for delivering cell cycle regulating machinery and ubiquitylated substrates to the proteasome for degradation. Control experiments demonstrate that background exchange among different complexes is negligible. At least ten protease inhibitors were characterized in hedgehog plasma including three macroglobulins. Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis. The cardiac isoform, encoded by MYBPC3, has been extensively studied over the last several decades due to its high mutational rate in congenital hypertrophic and dilated cardiomyopathy. We describe an improved technique which allows the analysis of enzyme reaction kinetics for gamma-glutamyl transpeptidase (gamma-GT) by flow cytometry. The categories of animals were distinguished by behavioral criteria: weight change, wounds received, offensive and defensive behavior, and freedom of movement. MicroRNAs (microRNAs) are abundant, approximately 21-25 nucleotide (nt) non-coding RNAs that mediate sequence-specific, post-transcriptional repression of mRNA targets.

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Pharmacokinetics and pharmacodynamics of a single dose of zoledronate in healthy dogs. Using the simian-human immunodeficiency virus (SHIV), we have investigated whether the blood-brain barrier (BBB) is compromised during the early stages of infection. Treatment with 8-OH-DPAT markedly increased the expression of MT in striatal astrocytes in the hemi-parkinsonian mice. Trypsin independent elastase has been purified by affinity chromatography on cellulose elastin column as a pure protein raction of molecular weight: 26,000 ou SDS acrylamide gels. This latter result was surprising, given positive correlations in mammals between testicle size and carotenoid concentration. Detection of antibodies to staphylococcal enterotoxins in the serum and milk of healthy goats. Eight well trained men and 8 well trained women (6 of them in the late luteal phase of their cycle) participated.

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Similar rewarding effects of testosterone in mice rated as short and long attack latency individuals. Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response. A structured review of published literature in peer-reviewed journals was conducted. Extracranial ligation was done bilaterally in three patients, temporarily in two. Male diabetes patients with a depressive disorder are particularly vulnerable to develop high levels of diabetes-specific emotional distress. Moreover, we take reckoning of ourselves stacked up against others, and ideally make moral decisions with others in mind. To our knowledge, there has been no previous case of pulmonary hypersensitivity due to Rikkunshi-to reported in the world. To evaluate the socio-demographic characteristics of major depressive disorders in the State of Qatar, which has a high percentage of expatriates. It has been assumed that the degree of elliptocytosis can be increased when the spectrin alpha chain, encoded by the alpha gene in trans to the variant, is expressed at a low level. To investigate the risk of bleeding events associated with concurrent administration of dabigatran-dronedarone compared with dabigatran standalone therapy using the Food and Drug Administration Adverse Event Reporting System (FAERS) database and to identify the characteristics of patients with bleeding events associated with concurrent use of dabigatran and dronedarone.

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Study of beta-carotene metabolism in humans using 13C-beta-carotene and high precision isotope ratio mass spectrometry. Furthermore, both flow patterns induced KLF2 and KLF4 expression in HCAEC and HSVEC. Doubly robust and efficient estimators for heteroscedastic partially linear single-index models allowing high dimensional covariates. In jawed vertebrates, Endothelin signaling involves multiple functionally distinct ligands (Edns) and receptors (Ednrs) expressed in various NCC subpopulations. The dry denture base resin demonstrated superior bond strength compared with the desiccated and water-saturated denture base resins. miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma. These results indicate the need for an intensive program to develop a definitive surgical procedure and prosthesis, with a view to applying the method to all types of laryngectomees. In order to make a systematic study of the significance of immunological reactions in vascular grafts, segments of abdominal aorta (4-5 mm long) were grafted into inbred rats. To investigate the mechanism of the action of glucocorticoid induced leucine zipper (GILZ) in inflammatory reaction.

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Patient 2 presented subarachnoid hemorrhage after aneurysmal re-rupture, and the procedure was completed under general anaesthesia. The aim of this study was to prospectively evaluate the feasibility of a novel total liver volume perfusion computed tomographic technique in demonstrating treatment-site recurrence of liver metastases after radiofrequency ablation (RFA). Growing interest in use of geographic information systems in health and healthcare research: a review of PubMed from 2003 to 2011. Parents with 2-5-year old children enrolled in community swim lessons completed the same survey measures up to 4 times over an 8-month period. The aleurone layer was found to be the primary determinant of seed dormancy. A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells.

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As small animal optical imaging and tomography are gaining popularity for interrogating functional and molecular events in vivo, it becomes increasingly necessary to gain knowledge of the optical properties of the species investigated to better understand and describe photon propagation through their tissues. In vivo phenotypic characteristics of AKR T-cell lymphomas with different leukemic potential: possible role of alpha 4 beta 7 integrin in the progression towards the leukemic phenotype. The presence in the patients of risk factors may provide evidence in favour of elective surgery. In clinical practice, interpretation of dynamic changes of troponin may be challenging. We found that serum deprivation of EC caused apoptosis, yet it did not induce E-selectin EC surface expression.

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Naphthalene exposure: effects on gene expression and proliferation in human cord blood cells. The most common etiologies are those of iatrogenic immunodeficiencies: surgery (especially splenectomy), radiotherapy, chemotherapy of leukemia and cancer, immunosuppressive treatments in organ transplanted patients. The effect of intrathecal dexamethasone injection on plasma cortisol level. Following phenylephrine pre-stimulation: beta-gamma methylene ATP was significantly more potent than ATP at inhibiting tension. Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity. Substitution of stavudine or zidovudine for abacavir or tenofovir partially improves noroxin drug class peripheral fat loss. Results indicate that the method should be usful in the future in assisting individualization of dosage regimens and in the study of the pharmacokinetics and metabolism of MTX in cancer patients.

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This child presented, three years after the trauma, a right side otitis media, complicated by meningitis and pneumococcal sepsis, which might have as consequence a left side deafness. Recently, we have proposed a mathematical data integration framework to discover cost of iv zyvox the miRNA-gene regulatory co-modules. TOR is a crucial sensor of intracellular and extracellular conditions that promotes cell growth and anabolism when nutrients and growth factors are abundant. Fifty-nine women with PMO were included (mean age 56.7 years), 44 completed course of therapy and were analyzed. Cyclic GMP-activated currents were measured in excised, inside-out membrane patches before and after treatment with either all-trans retinal (ATR) or all-trans C22 aldehyde, which is too long to fit into the chromophore binding pocket of opsin and therefore cannot activate the visual transduction cascade.

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However, extrapolation of the epidemiological data and results of acute experiments indicate that the impact on blood pressure is rather small. An Arabidopsis pex10 null mutant is embryo lethal, implicating peroxisomes in an essential role during plant embryogenesis. The device causes two coaxially transmitted pulsed beams with orthogonal polarizations to have the same polarization in order to implement amplification by the pumping effect. We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth, apoptosis, and tumorigenesis. Present study was designed to investigate the role of VEGF polymorphism in GBC and in other (benign) gallbladder diseases, that is chronic cholecystitis (CC) and xanthogranulomatous cholecystitis (XGC). Cheung-Bearelly monofilaments are accessible, disposable, and consistent esthesiometers. This conventional model is unable to account for rapid flexibility observed in human spatial generalization during motor adaptation. This study aimed to further characterize the effects of the vehicle used to administer acetone on the severity of acetone-potentiated CCl4-induced liver injury.

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Efficient white light generation in secondary cores of holey fibers. Duct-like structures in odontogenic epithelium of compound odontoma. End-points include safety, complications, mortality and cancer specific outcome including 5-year and median survival. Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism. Our results show that in the combined process of deciphering emotions from facial expressions and from context, OT gives an advantage to the face. The antagonist concentrations in the luminal and venous outflow were measured by high-performance liquid chromatography. Since FA patients are uniquely hypersensitive to DNA cross-linking agents, while oral cancer in the general population is thought to be environmentally induced, these results also suggest that environmental DNA cross-linkers may be causally involved in oral carcinogenesis. Perennial plants with relatively small leaves had moderate transpiration rates and leaf temperatures close to air temperature.

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Magnification in Drosophila: evidence for an inducible rDNA-specific recombination system. However, ineffective uterine contractility was significantly associated with maternal BMI and the risk of non-elective caesarean delivery due to can i take zantac 150 mg twice a day labour arrest disorders increased with increasing BMI, reaching a 4-fold increased risk among the morbidly obese women. We use a three-dimensional molecular-dynamics simulation including air phenomenologically. Detection of lymph node micrometastasis in esophageal carcinoma. Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines. Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms. Please send to Gary Jones 18 Hogarth Road, Stifford Clays, Grays, Essex RM16 2XA. In recent years, it has been demonstrated that mRNAs localize to axons of young and mature central and peripheral nervous system neurons in culture and in vivo. Leaf lettuce was grown in manure compost/top soil (0:5, 1:5 or 2:5 w/w) mixtures. Viral decline was measured at weeks (W) 4 and 12 and SVR assessed 6 months after the end of therapy.

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Assessment of thrombosis in right internal jugular vein after percutaneous superior vena cava catheter insertion during cardiovascular surgery with cardiopulmonary bypass. Detection of proliferating hepatocytes in patients with acute hepatic failure by mitotic figures and a monoclonal antibody against DNA polymerase alpha. Microfluidic parallel patterning and cellular delivery of molecules with a nanofountain probe. Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Socioeconomic, lifestyle and dietary factors associated with dietary supplement use during pregnancy. For instance, bacteria can communicate amongst themselves and with their hosts, by producing, sensing, and responding to chemical signals. Treatment of leukemia in relapse after bone marrow transplantation. nov., a novel thermoactinomycete vasotec generic equivalent isolated from a sediment sample, and emended description of the genus Marininema Li et al. The technique is illustrated by the thermal dissociation of CoBr(2).6H(2)O.

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This study raises the possibility that the aforementioned morphologic abnormalities are involved in the occurrence of uninhibited detrusor contraction and abnormal detrusor reflex in patients with lower urinary tract obstruction. Inherited MYH mutations predispose to colorectal adenomas and cancer. The ADHD symptom groups were comparable in age and symptoms of depression, anxiety, and substance abuse. The developing ovariole of the silkmoth Bombyx mori represents an excellent model for studies on the changes that occur in gene expression during the execution of long-term developmental programs. When the beamline cannot fulfill these demands, single-wavelength experiments may be a better option. This theory naturally explains an observed marked increase in dominance duration in binocular rivalry upon periodic interruption of stimulus and yields testable predictions for the distribution of perceptual alteration in time. The authors were unable to locate any published reports of fatigue failure of titanium cables in the fixation of atlantoaxial instability. Possible technique for percutaneous intravascular tamponade of the gastroesophageal varices. In addition, it is becoming increasingly evident that CYP1A1 plays an important role in the cefpodoxime cost medicare detoxication of environmental carcinogens, as well as in the metabolic activation of dietary compounds with cancer preventative activity.

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The performance of the rEPADs is comparable to commercial electrochemical cells, and the layout can be easily integrated into systems that permit multiplexed analysis and pipette-free sampling. Differences in minor histocompatibility antigens can apparently be overcome more easily by immunosuppressive drug therapy than differences in major histocompatibility antigens. The resulting univalents segregated in two uneven groups at the first division, and sister chromatids segregated to opposite poles at the second division, leading to the production of unbalanced spores. Senescent cell antigen appears on old cells and marks them for death by initiating the binding of IgG autoantibody and subsequent removal by phagocytes in mammals and other vertebrates. On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. However, long-term results must be obtained before it can replace the older technique.

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