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Calan (Verapamil)
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Calan

Calan belongs to a group of medicines called calcium channel blockers or calcium antagonists. Calan also helps to control fast or irregular heartbeats. They work by opening up blood vessels, which lets more blood and oxygen reach the heart and at the same time lowers high blood pressure.

Other names for this medication:
Calaptin, Covera, Isoptin, Vasopten, Veramil, Verapamil, Verelan, Verpitos, Zolvera

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Also known as: Verapamil

Description

Verapamil is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Verapamil is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, verapamil relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

This medicine is available only with your doctor's prescription .

Dosage

This section provides information on the proper use of a number of products that contain verapamil. It may not be specific to Calan SR. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Swallow the extended-release tablet whole with a full glass of water. Do not break, crush, or chew it. It is best to take this medicine with food .

If you cannot swallow the verapamil extended-release capsules, you may open it and sprinkle the pellets contained in the capsule on one tablespoon of applesauce. This mixture must be swallowed immediately with a glass of cool water. The applesauce should not be hot and should be soft enough to be swallowed without chewing. Do not chew or crush the pellets .

If you are taking the extended-release tablets, you may sometimes notice what looks like a tablet in your stool. This is the empty tablet shell that is left after the medicine has been absorbed .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (tablets): Adults—The usual dose is 80 to 120 milligrams (mg) three times a day. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets, 24 hr): Adults—At first, 180 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For heart rhythm problems: For oral dosage form (tablets): Adults—The total usual dose is 240 to 480 milligrams (mg) divided in three or four equal doses per day. Children—Use and dose must be determined by your doctor . For high blood pressure: For oral dosage form (tablets): Adults—At first, 80 milligrams (mg) three times a day. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release capsules): Adults—At first, 200 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once daily in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets, 24 hr): Adults—At first, 180 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor .

Overdose

If you overdose Calan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Calan overdosage: slow heartbeat, fainting fit.

Storage

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture, light and heat. Keep container tightly closed. Keep out of the reach of children.

Side effects

The most common side effects associated with Calan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of verapamil in the pediatric population. Safety and efficacy have not been established .

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Rhenium-186 hydroxyethylidene diphosphonate for treatment of painful osseous metastases from mammary carcinoma. To study brain regions involved in familiarity discrimination, rats were shown sets of novel and familiar objects. Thus, to attain Millennium Development Goal 6 (Combat HIV and/or AIDs, malaria and other diseases), it is crucial to seize the opportunity to educate and encourage teenagers about healthy choices and proper social behaviours that will continue into adulthood. We gauged the performance of the Service against present indicators by interviewing 120 callers who had contacted the Service during its first two years. Breast cancer is the most common cancer diagnosis in American women. A total of 58 items from published questionnaires were reduced initially by a hierarchical cluster analysis, then by factor analysis. The apparent Km for norepinephrine uptake by the cocaine-sensitive site is 5.8 microM when determined in the presence of 118 mM NaCl, obtained using nonlinear least-square curve fitting. Dobutamine stress echocardiography for the detection of significant coronary artery disease in renal transplant candidates.

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Antibiotics and drugs active against abdominal infections in newborn infants. The strains developing less successfully in vectors tended to have a relatively broad body (L119) or short flagellum (Neal). Retrospective analysis of the clock drawing item from the Cambridge Cognitive Examination (CAMCOG) presented to three independent raters. The data discussed in this publication have been deposited in The National Center for Biotechnology Information Gene Expression Omnibus database and are accessible through GEO Series accession number GSE52851. However, in order not to get erroneous conclusions, it is important to detect measurements with insufficient precision. A substantial level of mixed chimerism is required for the induction of permanent transplantation tolerance. The method was validated in terms of linearity, carryover, reproducibility and recovery rates, as well as using various plant tissues.As a first case study we present metabolic profiling of Arabidopsis root and shoot tissue of wild type (C24) and mutant (rsr4-1) plants deficient on vitamin B6. The early maturing girls were characterized by higher values of waist circumference, BMI, WHR and WHtR.

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A histological study confirmed that primary vascular damage was involved in both PDT treatments. The aim was to quantify the degree and duration of perioperative metabolic disturbance and to determine the relationship between the metabolic changes and the duration of surgery and total volume of blood and colloid given during surgery. The influence of scratches to metallic counterfaces on the wear of ultra-high molecular weight polyethylene. Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes. The effect of a quaternary ammonium biocide on the performance and characteristics of laboratory-scale rotating biological contactors. Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation. This rare association needs to be included in the differential diagnosis of mass lesions in both abdomen and chest. The empirical evidence suggests some movement toward consensus on the practice of palliative sedation. With an original design, the Carpentier-Edwards pericardial valve promised improved results, especially in small sizes.

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The results demonstrate that factors influencing prognostication differ across specialties. (1) Changes in management plan may occur in the majority of patients based on EUS results. Compared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Esophageal wall rupture after EUS-FNA for mediastinal staging is a severe complication. Chemokines were quantified using a Multiplex system and were identified by immunofluorescence histochemistry. Bioemulsans are produced by a wide diversity of microorganisms and have potential applications in the food, paper, paint, bioremediation, agriculture, detergent and cosmetics industries. Which question do polls about evolution and belief really ask, and why does it matter?. This study demonstrated the possible in-house preparation and quality control of (68)Ga-citrate, using a commercially available (68)Ge/(68)Ga generator for PET imaging throughout the country.

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3 weeks later, several layers of urothelium covered the whole surface of the matrix tube. Individuals with CKD would prefer, or find it more useful, to see nutrients of concern listed in absolute amounts on the NFL. This study examines the results of intralesional administration of PRP in the treatment of primary hamstring injuries sustained by players belonging to a major league football club. Our aim was to develop a scoring system to predict risk of microscopic colitis (MC), to identify patients at low risk, potentially avoiding unnecessary biopsies. Quantitative data included preoperative physical and clinicopathologic values. The prolapsed intestine was pulled back into the pelvic cavity, and the vagina and peritonium were repaired. As a result, we have established that in Xenopus levis, Zyxin binding to Ptc2 is due to the interaction of Zyxin 2nd LIM-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (1159-1412 aa). The raw proteomics and peptidomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003595. Circumscript lesions especially in the middle part of femur condyles can be seen easily by ultrasonography. This immunostimulatory effect may be of benefit in increasing the immunity to infectious diseases.

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Use of nucleic acid in the diagnosis and management of tuberculosis amplification tests. How anxiety about communication affects the role of nurse leaders in international social networks. Dynamic changes of both oligomerization of the human PrP and depletion of normal PrP(c) require further elucidation to develop a greater understanding of the pathogenesis of human prion diseases. The aim of this study was to determine that time interval in those patients. B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells. Experimental results show predicted MR images to be highly representative of actual MR images. evidence-based parenting intervention in rural Western Kenya: from parents matter!. Recent studies suggest that single-nucleotide polymorphisms (SNPs) within matrix metalloproteinase (MMP) genes and genes of tissue inhibitors of metalloproteinases (TIMPs) have an impact on the expression of these genes and on the prognosis for gastric cancer. We found that platelets must have albumin on the surface to respond to collagen and aggregate.

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Knowledge of their practice is limited, making support and evaluation of their programs difficult. On the basis of these results, the balance of forces controlling morphological transitions, interfacial electrokinetic properties, and the stability of the micelle aggregates was discussed. impL(M) mutants with substitutions or deletions in the Walker A motif failed to complement the impL(M) deletion mutant for Hcp secretion, which provided evidence that ImpL(M) may bind and/or hydrolyze nucleoside triphosphates to mediate T6SS machine assembly and/or substrate secretion. The purified peptide showed also antibacterial activity against clinically important gram-positive bacteria. Clinical and electrophysiological studies revealed evidence of left medial and lateral plantar nerve involvement. Selenium and mercury in the Brazilian Amazon: opposing influences on age-related cataracts. Autopsy revealed bilateral pleural effusions with pleural nodules involving the visceral and parietal pleura of both lungs. Migraine: selecting treatments now and making requests for the future?. The asymptotic theory can be modified for two-dimensional sound scattering by a cylinder array.

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To ensure safe use of TCZ in daily practice, physicians and patients should be aware that, under TCZ, LIP may occur with mild symptoms only and without CRP elevation. These results are consistent with those in clinical max xanax dose per day studies supporting the use of the DEX implant for the extended management of posterior segment diseases. Bone marrow relapse developed three months later, and she died 11 months after BMT. In vitro study also demonstrated that cellular uptake of a negatively charged liposome was higher than positively charged or neutral liposomes. Higher pulsatility was associated with progression in lacunar infarction. Four hybrids were identified, two of which had not been recognised morphologically as hybrids, and one of these was thought to be a C.

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Despite the knowledge of these viruses since the 1970s, vaccination strategies have not been implemented, leading to continuous re-emergence of novel virulent strains. There was no significant difference between the oogenic development and dimensions of ovarian follicles of healthy females compared to those reared from infected larvae. Distinguishing ventricular septal bulge versus hypertrophic cardiomyopathy in the elderly. We propose that precursors of the floor plate and neural crest were present in a common ancestor of both vertebrates and ascidians. Dynamics tenormin 50 mg para que sirve of a modified Leslie-Gower predator-prey model with Holling-type II schemes and a prey refuge. A pilot study of idiotypic vaccination for follicular B-cell lymphoma using a genetic approach. No substantial right or left asymmetry was found, nor did the addition of the indirect dopaminergic agonist amantadine influence these results. Use of neuraxial anesthesia with selective factor Xa inhibitors.

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Group A is composed of patients requiring re-resection as a result of the hepatic re-recurrence of the neoplasia (three hepatocellular carcinomas, nine metastases from colorectal carcinoma, and two metastases from carcinoid tumor). Two cases of Cryptococcal meningitis were encountered in the recent past. It is suggested that there is a strong possibility that high-dosage testosterone may act as a male contraceptive. A correlative morphometric and clinical investigation of hypoganglionosis of the colon in children. A case of localized pleural mesothelioma inducing hypoglycemic coma is presented.

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These alterations in hindbrain, neural crest, otic anlage, and pharyngeal arch morphogenesis could contribute to some of the craniofacial malformations in the macaque fetus associated with exposure to cRA. To review systematically the evidence for the management of orthostatic hypotension (OH) in patients with spinal cord injuries (SCIs). Early renal damage assessed by the SLICC/ACR damage index is predictor of severe outcome in lupus patients in Pakistan. Efficacy and adverse effects of prophylactic antiemetics during patient-controlled analgesia therapy: a quantitative systematic review. Changes in indices of ventricular filling, size and function during graded levels of lower body negative pressure: comparison between normal and transplanted hearts. Some clinical observations of disturbances of the taste sensation.

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