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Assepium (Trimethoprim)

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Assepium (generic name: Co-trimoxazole; brand names include: Septra / Ciplin / Septrin) is a combination of two antibiotics (trimethoprim and sulfamethoxazole) used to treat a wide variety of bacterial infections.

Other names for this medication:
Alfatrim, Anitrim, Bactipront, Bactiver, Betam, Bismoral, Bitrim, Cadiprim, Comox, Cotreich, Cotribene, Cotripharm, Doctrim, Droxol, Drylin, Escoprim, Eusaprim, Forcrim, Gantrisin, Gentrim, Kaftrim, Kombitrim, Linaris, Lupectrin, Metrim, Novidrine, Octrim, Onetrim, Ottoprim, Qiftrim, Ribatrim, Roxtrim, Sanprima, Sigaprim, Sitrim, Sulfa, Sulfamethoxazolum, Sulfametoxazol, Sulphatrim, Terbosulfa, Theraprim, Triforam, Trimaxazole, Trimesulf, Trimosul, Tripur, Trisulf, Trisulfose, Trizole, Xepaprim

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Also known as: Trimethoprim


This medication is a combination of two antibiotics: sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections). It is also used to prevent and treat a certain type of pneumonia (pneumocystis-type). This medication should not be used in children less than 2 months of age due to the risk of serious side effects. This medication treats only certain types of infections. It will not work for viral infections (such as flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.


Take Assepium exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Drink plenty of fluids to prevent kidney stones while you are using this medicine.

Sulfamethoxazole and trimethoprim doses are based on weight in children. Use only the recommended dose when giving this medicine to a child.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. This medicine will not treat a viral infection such as the flu or a common cold.

You may need frequent medical tests.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Assepium.

Store at room temperature away from moisture, heat, and light.

Detailed Assepium dosage information


Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Assepium DS dosage information

Side effects

The most common side effects associated with Assepium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Assepium could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

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Absorption and metabolism of cyanidin 3-O-beta-D-glucoside in rats. PPARgamma agonists inhibit vasopressin-mediated anion transport in the MDCK-C7 cell line. These results have implications for peptide and mRNA flux across the nuclear membrane during conditions where lipid oxidation may be expected. As alphaMbeta2-integrin blockade reversed the postischemic, inflammatory phenotype of Cd39-/- mice, these data suggest that phosphohydrolytic activity on the leukocyte surface suppresses cell-cell interactions that would otherwise promote thrombosis or inflammation. The cold hardiness of Ixodes scapularis Say unengorged larvae, engorged larvae, unengorged nymphs, engorged nymphs, and unengorged adults was evaluated.

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Lower urinary tract symptoms: lack of change in prevalence and help-seeking behaviour in two population-based surveys of women in 1991 and 2007. A correct diagnosis of coeliac disease, one of the most common chronic diseases in Swedish children, demands small bowel biopsy, which can be performed endoscopically or by means of a peroral capsule. Additional proof of the assigned trans-C/D-junction of the key intermediate 18-nor Grundmann type ketone follows from its chiroptical properties (circular dichroism data) and further chemical transformations. Use of daily ultrasound or CBCT imaging can help to reduce PTV margins and protect organs at risk compared to the use of skin mark-based positioning. Receptor RNAi led to a significant reduction in HmLAR1 expression by the injected cells and resulted in a significant decrease in sprouting and regenerative growth at the crush site relative to controls. Further, the efficacy of AG to attenuate ketamine-induced social withdrawal was examined in the social interaction test.

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We conducted a systematic observation of bars and clubs with events targeted to African American adults 18-25 in Baltimore City at two timepoints (October and November of 2008 and 2010) after enforcement of the Maryland Clean Indoor Air Act (CIAA). IL-2 and IFN-gamma mRNAs remained high up to 24 hr while IL-1 beta mRNA decreased strongly. Although the potential of these therapeutic approaches have been demonstrated in vitro or have been used for the treatment of other infections, their use in man, and so their future and potential efficacy, require further investigation. Effective efficacy was primarily judged when complete response (CR) or partial response (PR) was obtained at month 6. Consuming desalinated seawater (DSW) as drinking water (DW) may reduce magnesium in water intake causing hypomagnesemia and adverse cardiovascular effects. These experiments evidently demonstrate that the unified algorithm has both good blind deconvolution performance and high-resolution image restoration. Decomposition of the inhomogeneous distribution functions into Gaussians and the analysis of the fit results suggest that one of the locations for mesoporphyrin is between the two lipid layers, and the other one is between the hydrocarbon chains of the lipid molecules. Research oncologists can stratify individuals participating in studies using prognostic criteria based on tissue diagnosis and disease staging. High-throughput pyrosequencing analysis of bacteria relevant to cometabolic and metabolic degradation of ibuprofen in horizontal subsurface flow constructed wetlands.

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The treatment of isolated cell nuclei with citric acid was described as a method for separating inner and outer nuclear membrane. A solid-phase approach is described that provides facile access to monofunctionally trans-PtII-modified PNA oligomers of arbitrary sequence for potential use both in antigene and antisense strategies. It is used after dental malocclusion has been corrected and facial morphological features have been reassessed (soft tissue changes consecutive to maxillary osteotomy should be previously analyzed by cephalometry). Initial, final, at least 2-years postretention models, and initial lateral cephalograms were analyzed. MT-8L expressed both histiocytic and myofibroblastic phenotypes. Thus, improved access to community-based behavioral health services and an increased capacity for inpatient psychiatric hospitals for treating indigent patients may be needed to improve the efficiency of ED services in our region for patients with behavioral health conditions. Our case indicates a new aetiology for a pancreaticoduodenal artery aneurysm and demonstrates the rapid deterioration of the patient affected. Lifting speed preferences and their effects on the maximal lifting capacity.

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Integrated infectious disease surveillance information systems have the potential to provide important new surveillance capacities and business efficiencies for local health departments. In terms of number of fatal breast tumours, the favourable screening period is 40-80 years. After an extensive, clinical examination, a definitive diagnosis still had not been achieved. Commentary on the interpretation of the cytological analysis of blood. No evidence of recurrence was observed during a 3-year follow-up period. The scale, called the Shoulder Fatigue Scale-30 Items (SFS-30) risk assessment, was used to determine the severity of patient neck and shoulder discomfort. Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests. Aspartate Decarboxylation Encoded on the Plasmid in the Soy Sauce Lactic Acid Bacterium, Tetragenococcus halophila D10.

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The higher the number and quality of the triangles, the better the approximation. Evolution of sleep apnea syndrome in sleepy snorers: a population-based prospective study. In the present study, fluorescence in situ hybridization (FISH) was used to investigate non-homologous pairing in haploid rice during meiosis. Despite the success of nanocarrier systems to improve drug/gene therapy for cancer, active targeting specificity remains a major hurdle for GBM. To evaluate the mechanisms underlying pain related to dry mouth, the dry-tongue rat model was developed. Evaluation of a new Variant II HbA(2)/HbA(1c) Dual kit capable of both Hb A(1c) quantitation and hemoglobinopathy investigation on a single kit. The early response genes, c-Fos and c-Jun, are induced by environmental stress and are thought to modulate injury processes via the induction of AP-1-dependent target genes. The purpose of this study was to determine whether covalent modifications of ARNT occur between ARNT existing in the monomeric form and after heterodimerization with the AhR and subsequent binding to DNA. Rate of postoperative complications, premorbidity, previous surgery, concurrent procedures, postoperative dressings, and follow-up status. Monodehydroascorbate reductase 2 and dehydroascorbate reductase 5 are crucial for a mutualistic interaction between Piriformospora indica and Arabidopsis.

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In addition, the ASA, APACHE II, and SOFA scores were documented. Patient compliance was a limiting factor in this treatment effect. Denervated but not innervated skeletal muscles secrete polypeptides that are involved in neuromuscular synapse formation. Informations on the properties of breastfeeding given to mothers by health care professionals may influence them in their choice of breast feeding or not their ill newborn. The mean difference between the actual and predicted calving dates was 0.9 day with a standard deviation of 9.0 days. Patient 2 was a 64-year-old woman who presented with an upper-extremity thrombus and was discovered to have a FV inhibitor, likely secondary to antibiotics. Gonadotropin-releasing hormone fibers contact POMC neurons in the hypothalamic arcuate nucleus.

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7S globulin from soybean is metabolized in human cell cultures by a specific uptake and degradation system. 3) After repeated administration of LPS, rats became tolerant to LPS, in which state LPS induced neither fever nor COX-2 mRNA in blood vessels/leptomeninges. To compare the functional results from a prospective randomized trial of two different reflux-prevention techniques for ileal bladder substitution. Thirty-three patients were treated at doses of 100 to 250 mg/m(2)/d MG98. Human mutations have shed light on the molecular control of GnRH neuronal embryogenesis and have elucidated elements critical in sexual development. Improving safety in the operating room: a systematic literature review of retained surgical sponges. Hemophilia is an X chromosome linked disease characterized by an increased tendency to hemorrhage. PHF on-line is a predilutional hemodiafiltration treatment with better tolerance than hemodialysis with standard bicarbonate dialysate. Relationship between haemagglutination and pathogenicity in strains of Haemophilus isolated from the eye. Although unstudied, ACE may also be an important inactivator of bradykinin and various neuropeptides which in turn may participate in the immunoregulation of the granuloma.

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Until recently, therapeutic options for the treatment of the symptoms of IC have been limited, and the efficacy of available treatment has been questioned. Taking compliance into account, we compared the efficacy and trial effectiveness of weekly and daily iron supplementation during pregnancy. A-72-year-old male treated earlier for synchronous double malignancy.(invasive papillary urothelial carcinoma right ureter and carcinoma prostate) presented with rising PSA.( and referred for Ga-68 PSMA PET-CT, which showed a positive enlarged left supraclavicular lymph node. Here we describe a 63-year-old ET patient who showed myelodysplastic transformation (RAEB-t) of the primary disease after about eight years of therapy with pipobroman at variable dosages. Three structurally diverse groups of analytes, amino alcohols (beta-blockers), chlorophenoxypropionic acids, and branched-chain amino acids, in various mobile phase compositions/separation modes were examined. Serum levels of activin A were significantly higher in RA, SLE and OA than controls and in RA and SLE versus OA The mean values of serum inhibin A were significantly higher in all studied groups than controls. Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

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Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen. We compare spectral-domain optical coherence tomography (SDOCT) measurements of minimum rim width (MRW), minimum rim area (MRA), and peripapillary retinal nerve fiber layer thickness (RNFLT) to complete orbital optic nerve axon counts in nonhuman primates (NHP) with unilateral experimental glaucoma (EG). At the time of publication, a phase II trial in patients with IPF and a phase III trial in patients with PAH was ongoing. We review the controversy over lymph node dissection, and recent recommendations for the use of lymphoscintigraphy. The expression of the NRF2 pathway in human IPF and NSIP is further evidence that the pathogenesis of human fibrotic lung diseases is oxidant-mediated and originates from the alveolar epithelium.

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During the past decade, there has been a rapid increase in application of new technology and drug for STEMI in the eastern urban China. Information on smoking status, physical activity, disease history, social class and medication use was reported in the HLQ. Possible etiological factors include infectious agents, psychiatric disorders, and personality characteristics. We propose that JAK2 E846D predominantly contributes to erythrocytosis, but is not sufficient for the full pathological phenotype to develop. Both NK and NKT cell cytotoxicity and IFN-gamma production increase in very old age with respect to normal aging, especially by NKT cells bearing TCRgammadelta. Participation in leisure activities among boys with attention deficit hyperactivity disorder.

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We compared these characteristics in successful versus unsuccessful IVAT lifting attempts. A small change in saturated by polyunsaturated fatty acid intake may improve plasma lipid parameters in mildly hypercholesterolemic subjects. Interventricular dyssynchrony in a patient with a biventricular physiology and a systemic right ventricle. Nevirapine is the first member of a new therapeutic class (NNRTI: non nucleoside inhibitors of the reverse transcriptase) in the treatment against human immunodeficiency virus (HIV). We present a rare case of simultaneous involvement of larynx and ear in a patient with pulmonary tuberculosis. Animals improved only slightly from the effects of treatment following a 4-wk recovery period. High-dose chemotherapy and autologous stem cell transplantation in advanced epithelial ovarian cancer. Involvement of mitogen-activated protein kinase and translocation of cytosolic phospholipase A2 to the nuclear envelope in acetylcholine-induced prostacyclin synthesis in rabbit temovate cream dosage vs coronary endothelial cells. The PROGRESS international sepsis registry demonstrates that a large web-based sepsis registry is feasible.

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Thus, the coefficient of variation is not a valid measure of sincerity of effort. Selection for Streptococcus mutans with an altered xylitol transport capacity in chronic xylitol consumers. Prospective validation of a biomarker panel to identify pediatric ED patients with abdominal pain who are at low risk for acute appendicitis. Importantly, larger agonist affinity shifts were observed for AT(1A)-beta-arrestin2 than for AT(1A)-beta-arrestin1. Inclusion criteria were: admission to ICU between 2005 and 2007 during pregnancy or within 42 days of delivery. Our novel approach to quantifying both inhibitory and co-agonist effects of pentobarbital provides a basis for future structure-function analyses of GABAA receptor mutations in putative pentobarbital binding sites. Our observations establish a causal link between an ezrin-radixin-moesin protein mutation and a primary immunodeficiency that could be referred to as X-linked moesin-associated immunodeficiency. Histopathologic changes induced by serotype II infectious bursal disease virus in specific-pathogen- is it safe to take 20 mg of zyrtec free chickens. The study investigated each step of the EAPCRI protocol by elimination and monitored the influence on Aspergillus PCR performance. CSC doses above 30mug/ml induced a significant increase in apoptosis in BEAS-2B cells evidenced by an increase in activated caspase 3, an increase in mitochondrial mass and a decrease in mitochondrial membrane potential.

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Radiologic issues in lung transplantation for end-stage pulmonary disease. The present results are relevant to the design of imaging experiments with partially coherent sources, as well as to the analysis and interpretation of the corresponding images. Three groups of 12 children were matched on age, IQ and sex as well as degree of kinaesthetic and motor impairment. These results suggest that crosslinking of collagen fibrils by nonenzymatic glycation alters the physical properties of the extracellular matrix, resulting in changes in the organization of the intracellular actin cytoskeleton. Are sodium-dependent V1 receptors and sympathetic nerve activations involved in regulation of blood pressure in borderline-hypertensive Hiroshima rats?. amaryl renal dosing The possible contraceptive effect of antiprogestins has been evaluated in both clinical and experimental studies. In linear regression analysis, HDL-C was not an independent predictor for modified Gensini scores. Thus, engaging the education sector as participants in the work of the Developmental Origins of Health and Disease community offers an important strategy to capture the potential of adolescence as a life stage for transgenerational primary prevention of obesity and NCD risk.

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New insights into mechanisms of gamma-diketone-induced axonopathy. Therefore, it is possible that lipids in the small intestine, where trophozoites colonize, play key roles in regulating the growth and differentiation of this important pathogen. The impact of Medicaid managed care on community clinics in Sacramento County, California. Result of the treatment of ichthyosis with administration of normal horse serum. Intriguingly, the catalytic subunit of DNA-PK also contains a hexa-heptad repeat of leucines. One small study suggests that short term effects of intravenous milrinone may be superior to those of oral captopril, and it appears that the addition of captopril to milrinone therapy may produce a synergistic haemodynamic effect. In contrast, experiencing support from family and friends, though unlikely to reduce yearning, might ameliorate these general grief symptoms as well as depression.

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This paper is a review of early results in thymus research that found their full significance after several decades, when the strategic role of the organ in immunology was recognized. Fluid accumulation at the tip of a dislodged (epidural) catheter temporarily caused apparent coupling of fluid pressures across the dura. MK386: a potent, selective inhibitor of the human type 1 5alpha-reductase. Cocaine inhibits muscarinic cholinergic receptors in heart and brain. The synergism of anticellular and antiviral activities of recombinant human interferon-gamma (ReIFN-gamma) and recombinant human interferon-beta (ReIFN-beta) was examined in vitro using human melanoma SK-MEL-28 cells. Combined 595-nm and 1,064-nm laser irradiation of recalcitrant and hypertrophic port-wine stains in children and adults. Islet blood flow was measured using a non-radioactive microsphere technique, tissue oxygen tension was recorded with Clark microelectrodes and insulin concentrations were determined by enzyme-linked immunosorbent assay technique. The patient was treated surgically allowing gastric decompression, gastropexy and Nissen intervention. AGE-albumin, a prototypic ligand, activated p21(ras) in rat pulmonary artery smooth muscle cells that express RAGE, whereas nonglycated albumin was without effect.

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Null mutations in dSyx5 are larval lethal and demonstrate impaired transport of a GFP-tagged membrane protein. The tumor idiotype differs, however, from what class of medication is zetia patient to patient, making it a technical challenge to exploit for therapy. In cardiovascular operations, we have usually used heparin-coated cardiopulmonary bypass circuits with low systemic heparinization. The immunomodulatory potential of the fusion protein was also analyzed in non-obese diabetic (NOD) mice, an animal model for human type 1 diabetes. The novel G5538A mutation was identified in different tissues DNAs from the proband and from her mother. Preventing technology-induced errors in healthcare: the role of simulation. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels are linked to adverse outcomes in human immunodeficiency virus (HIV) infection, but the strength of their associations with different clinical end points warrants investigation. These experiments show that restoration of euglycemia by islet transplants is capable of preventing experimental diabetic glomerulopathy and reversing early changes in renal function and structure induced by diabetes.

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From 1973 to 2006, 45 patients with a serous borderline tumour and peritoneal implants relapsed among 162 patients with a follow-up exceeding 1 year. A cross-sectional survey design was used to investigate aspects of antimicrobial prescribing and electronic devices experienced by patients at four hospitals in London and a teaching hospital in the East of England. The NHS is developing very differently in the four countries of the UK. HTLV-III infection of EBV-genome-positive B-lymphoid cells with or without detectable T4 antigens. Women at risk of breast cancer report interest in lifestyle modification, but recruitment to randomized physical activity intervention studies is challenging.

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Successful surgical treatment of spontaneous rupture and dissection of the abdominal aorta in Ehlers-Danlos syndrome has not been previously reported. Efficacy and safety of procainamide in preventing arrhythmias after coronary artery bypass surgery. Myocarditis as an immune-related adverse event with ipilimumab/nivolumab combination therapy for metastatic melanoma. Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine. Scientists are looking to exploit the pro-apoptotic function of mitochondria to trigger the death of cancer cells. The UVD scale peaked at score 2-3 and again at 6 for air sensitivity, but conformed to the other scales by peaking at score 2 for tactile sensitivity. Here we study the role of the Andes in the evolution of a diverse Neotropical insect group, the clearwing butterflies. The results suggested that pitavastatin did not affect the drug-metabolizing systems. Case control study: magnetic resonance spectroscopy of brain in HIV infected patients.

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