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Araten (Losartan)

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Araten belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Araten is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Angioten, Angizaar, Arapres, Araten, Cardoplus, Cartan, Cozzar, Fortzaar, Klosartan, Lepitrin, Logika, Lopernal, Loplac, Losadrac, Losagen, Losalet, Losapot, Losapres, Losardil, Losargamma, Losartas, Losartic, Losartil, Losium, Lospre, Lotan, Lozar, Maxartan, Normatens, Portiron, Prosan, Rasoltan, Simperten, Sortal, Tacardia, Tanlozid, Xartan

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Also known as: Losartan


Araten (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Araten is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Araten is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Araten 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Araten 25 mg, Araten 50 mg, and Araten 100 mg may also contain carnauba wax.


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Araten dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Araten are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Araten if you are allergic to Araten components. Do not take Araten if you're pregnant or you plan to have a baby, or you are a nursing mother. Araten can harm your baby. Do not use Araten if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Araten if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Araten suddenly.

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The results of this study suggest that intratumoral injection of human telomerase ribonucleic acid(hTR) ASOND could effectively inhibit the growth of implanted tumor in nude mice. Data on morphology and natural history, as well as the first life photographs are provided. Pericholecystic rim sign on PET/CT secondary to locally invasive gallbladder carcinoma. The dependence of the recurrence time (one period) and Liapunov exponent on both speedup and the number of bus stops is calculated for distinct dynamic states. The reaction between the Ti sample and NaOH alkaline solution resulted in the formation of a layer of amorphous sodium titania on the Ti surface, and this layer can induce apatite deposition. Pharmacotherapy for peripheral arterial disease: emerging therapeutic options. Medicare provides the majority of funding to support graduate medical education (GME). A Nanoarchitecture Based on Silver and Copper Oxide with an Exceptional Response in the Chlorine-Promoted Epoxidation of Ethylene.

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The high vulnerability of women against influenza A virus infections during pregnancy was repeatedly highlighted during influenza pandemics including the pandemic of this century. Microcell-mediated chromosome transfer from the hybrid pools to xeroderma pigmentosum complementation group A (XP-A) cells in culture and selection for G418-resistant colonies resulted in the identification of XP cells with enhanced resistance to ultraviolet radiation. Subjects then experienced the CRI which showed whether different BG values were low, in range, or high. Although supportive social relationships are often associated with attenuated patterns of HPA and SNS activation, the converse also seems to be true as nonsupportive social interactions are frequently associated with enhanced reactivity. Mammalian host response to pathogenic infections is controlled by a complex regulatory network connecting regulatory proteins such as transcription factors and signaling proteins to target genes. One-pot syntheses of dissymmetric diamides based on the chemistry of cyclic monothioanhydrides. Niche localized HGF plays an integral role in G(0) exit and the return to mitotic activity of adult skeletal muscle satellite cells.

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Functional atlas of the awake rat brain: A neuroimaging study of rat brain specialization and integration. It is thought that frontostriatal circuits play an important role in mediating conditioned behavioral responses to environmental stimuli that were previously encountered during drug administration. A splice site mutation in HERC1 leads to syndromic intellectual disability with macrocephaly and facial dysmorphism: Further delineation of the phenotypic spectrum. Prevention of this glomerular hypertension by reduction in dietary protein or by the addition of converting enzyme inhibitors affords protection. Coronary arteriography demonstrated coronary artery-ventricular fistulas (left coronary artery to left ventricle, right coronary artery to right ventricle). Control of SVR angiosarcoma is mediated through T lymphocytes, and both CD4 and CD8 lymphocytes are capable of controlling SVR angiosarcoma growth in vivo. To determine whether exposure to mobile telephone radiofrequency (RF) fields, either acutely or long-term, produces up-regulation of the water channel protein, aquaporin-4 (AQP-4). In human pregnancies with DHCR7 deficient fetuses large amounts of 7- and 8-dehydrosteroids are excreted, products secondary to high fetal 7- and 8-dehydrocholesterol (DHC) accumulation. Hotspots of differential DNA methylation were enriched in genes involved in immune response and chromatin reorganization. In some pathological conditions, gingivitis caused by plaque accumulation can be more severe, with the result of an overgrowth.

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Lactic acidosis in the rectal lumen of patients with septic shock measured by luminal equilibrium dialysis. Neonatologists involved in this procedure must be encouraged joining a national data collection and registry. What is your diagnosis?: Multifocal subcutaneous tumors in a young male baboon. No study has examined the longitudinal trends in National Council Licensure Exam for Registered Nurse (NCLEX-RN) applicants and pass rates among internationally-educated nurses (IENs) seeking to work in the United States, nor has any analysis explored the impact of specific events on these trends, including changes to the NCLEX-RN exam, the role of the economic crisis, or the passing of the WHO Code on the International Recruitment of Health Personnel. Investigations into the relationship between saliva and dental caries. The reliability of the model was analyzed by comparing the actual data with the numerical results. Our present study demonstrates that levels of TN, MMP-9, and proliferative activity are increased in cholesteatomas. Penectomy confirmed the diagnosis of B cell malignant lymphoma, diffuse large type.

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Microvesicles (MVs) are circular fragments of membrane released from the endosomal compartment as exosomes or shed from the surface membranes of most cell types. Seriously ill hospitalized adults enrolled in the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT). Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus. Analysis of sequential steps of nucleotide excision repair in Escherichia coli using synthetic substrates containing single psoralen adducts. The interchange of functionally relevant organisms like zovirax tablets price south africa insects occurs through these edges and can influence ecosystem functioning in both crop and non-crop habitats. Insulin alone at concentrations of less than 1 to 5 uU/ml increased the enzyme activities of glycogen synthase, synthase phosphatase, phosphorylase, and phosphorylase phosphatase in hepatoma H4 cells in culture in the presence and absence of serum. Effects of calorie restriction and aging on the expression of antioxidant enzymes and ubiquitin in the liver of Emory mice.

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Light energy absorption by porphyrins results in the generation of oxygen reactive species, overcoming the protective cellular mechanisms and leading to molecular, cell and tissue damage, thus amplifying the porphyric picture. We therefore describe a simple and rapid technique that rids genomic DNA samples of melanin, resulting in a genomic DNA template that allows successful PCR. Furthermore, the effect of PG on the activation of macrophages by Escherichia coli-lipopolysaccharide (LPS) was studied. The continuous progress in hardware resulting in higher sensitivity must be coupled with advances in data acquisition schemes. To demonstrate the temporal course of obesity development in Japanese school children by conducting a school-site cohort study over 12 years. Glioblastoma is the most common and aggressive primary brain tumor. These facts suggest a possible interaction between glyoxylic acid and monoaminergic neurotransmission. There are potential hazards with ACE inhibitor therapy but most problems can be anticipated and avoided. Crystallization of an alpha-amylase, AmyA, from the thermophilic halophile Halothermothrix orenii.

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We show that the Japanese yellow swallowtail (Papilio xuthus, Papilionidae) and the painted lady (Vanessa cardui, Nymphalidae) butterflies have a second R7-like photoreceptor in each ommatidium. Chromosome condensation, a process mediated by the condensin complex, is essential for proper chromosome segregation during cell division. In addition, it is valuable for studies of comparative functional neuroanatomy in mammalian brains. Vesnarinone is an experimental drug which is known to inhibit TNF alpha release. We previously reported the effectiveness of a 12-week physical activity behavior change intervention for breast cancer survivors postintervention with this report, aiming to determine delayed and/or persistent effects 3 months after intervention completion. Microcomputer programmes specifically designed for this purpose were used in the data collection and subsequent analysis. Conceivably, the polycythemia vera (PV) complicated by hepatic vein thrombosis and portacaval shunt resulted in significant loss of hepatic reticuloendothelial system function and predisposed the patient to bacterial peritonitis. Enhanced expression and differential inducibility of soybean chalcone synthase genes by supplemental UV-B in dark-grown seedlings. A continuing lack of nurses in schools will worsen the crisis in child mental health. Besides other investigations, large scale analysis of aspartic acid repeat polymorphism will be needed for clarification of the bactrim forte suspension precio asporin dual role in progression of breast cancer.

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