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Angizem (Diltiazem)

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Angizem hydrochloride is a first generation calcium channel blocker that is widely used in the therapy of hypertension and angina pectoris. Angizem therapy is associated with serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Amethopterin, Estrace, Zyrtec, Seroquel, Calan, Avodart, Elavil, Casodex, Flutiriv, Gabator, Broncure, Rowasa, Repaglinide,

Also known as: Diltiazem


Diltiazem is used alone or together with other medicines to treat angina (severe chest pain) or hypertension (high blood pressure). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Diltiazem is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, diltiazem relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Angizem CD. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Angizem LA dosage information

Side effects

The most common side effects associated with Angizem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Angizem if you are allergic to diltiazem, or if you have:

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); very low blood pressure; or if you have recently had a heart attack and you have a build-up of fluid in your lungs.

To make sure Angizem is safe for you, tell your doctor if you have:

kidney disease; liver disease; congestive heart failure; or if you also take digoxin, or a beta blocker (such as atenolol, carvedilol, metoprolol, propranolol, sotalol, and others).

It is not known whether Angizem will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Diltiazem can pass into breast milk and may harm a nursing baby. You should not breastfeed while using this medicine.

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TGF-beta stimulation resulted in the growth inhibition of wild-type mink lung epithelial cells and to a lesser extent of the type I and type II TGF-beta receptor-defective mutants, although higher concentrations of TGF-beta were required for the growth inhibition of these mutants. Proteomic analysis of secreted muscle components: search for factors involved in neuromuscular synapse formation. Intrasellar adenoid cystic carcinoma and papillary mucinous adenocarcinoma: two previously undescribed primary neoplasms at this site. Can megadoses of thiamine prevent ethanol-induced damages of rat hippocampal CA1 pyramidal neurones?. The ionic composition, pH, and osmolality should approximate aqueous humor to prevent damage to the corneal endothelium. Nevertheless, there is an increasing body of evidence linking most these drug-associated events to SRL dose. Several investigators have proposed that there are two functionally distinct pools of PtdIns, one responsive to stimulation and the other not, and that the stimulus-responsive pool may be synthesized at a different site within the cell, perhaps within the plasma membrane.

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Cognitive training offers a promising way to mitigate cognitive deterioration in individuals with mild cognitive impairment (MCI). The clinical utility of CTCs and other blood biomarkers should be prospectively tested. Human monoclonal antibodies derived from lymph nodes of a patient with breast carcinoma react with MuMTV polypeptides. The following variables were analyzed: incidence of Pressure Ulcers, risk score according to EMINA, ulcer grade and location. Elevation of gastric pH by H2-receptor antagonists, such as nizatidine, does not result in clinically important changes in the rate or extent of oral dapsone absorption. Impairment of growth should be considered when assessing the risk-benefit profile of peginterferon/ribavirin therapy in children with hepatitis C virus infection. The latter group is especially well-known for engaging in everlasting arms races with their hosts. Compounds were analysed by means of gas chromatography (GC) and mass spectrometry (MS). NMDA receptor blockade attenuates the haloperidol induction of Fos protein in the dorsal but not the ventral striatum. In this article we will describe features of the diagnosis and treatment of these disorders.

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Both of her parents have been actively involved in her diabetic management. Despite the high colonization rates, topical antibacterial treatment was not found superior to non-antibacterial treatment. Electrochemical degradation of sodium pentachlorophenol on a Pd/C gas-diffusion electrode. The results of dating of extreme climatic events by damage to the anatomical structure and missing tree rings of the Siberian larch in the upper forest boundary of the Altai Republic are given. Brucella suis is also emerging as an agent of infection in cattle, thus extending its opportunities to infect humans. It improves embryo development and cumulative PR and is also recommended in poor responding cycles. Unilateral volume reduction of the PMM was found in 5 women of whom 2 were studied with MR. During the fourth week of the study, the evening Uniphyl dosing schedule resulted in significantly (p less than 0.01) higher home-monitored morning peak expiratory flow rates and fewer nighttime awakenings than the pre-study twice-daily theophylline regimen.

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In addition, the SDS contributed significant incremental validity over the D scale and showed greater accuracy in identifying nondepressed individuals. The neuroanatomy and functional morphology of the auditory system of the cicada Okanagana rimosa (Say) are documented for the adult and the three last larval stages. Absolute concentrations of N-acetylaspartate, creatine, choline, glutamate/glutamine, and myo-inositol and the ratios of metabolites in the anterior cingulate cortex, left dorsolateral prefrontal cortex, and left thalamus were measured using H-MRS at 1.5 Tesla. Over the past thirty to forty years tremendous strides have been made in understanding the origins of cancer. cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP. ST-segment elevation (at rest or during exercise) is not related to the evolution of volumes or regional dysfunction during the first 6 months after infarction.

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Evaluation of pituitary function in children using growth hormone secretagogues. However, the relative expression of these proteins in the DRG after cervical nerve root compression are not known. Selectins and their ligands: current concepts and controversies. The discovery that most women with PCOS are insulin-resistant and have compensatory hyperinsulinemia, with increased risk for type 2 diabetes mellitus, designates this condition as a reproductive-metabolic disorder. Amongst a diverse group of macroparasites, only levels of the nematode Heligmosomoides polygyrus and the louse Polyplax serrata were correlated (negatively) with innate immune responsiveness (measured by splenocyte tumour necrosis factor alpha responses to a panel of toll-like receptor agonists).

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Besides, double Langmuir probe and electron spin resonance spectroscopy were used to determine the temperature of electrons (ions) and the concentration of free radicals, respectively. A novel concept for octave spanning dispersive mirrors with low spectral dispersion oscillations is presented. The radial depth-dose distribution of a 188W/188Re beta line source measured with novel, ultra-thin TLDs in a PMMA phantom: comparison with Monte Carlo simulations. In patients with cerebritis or encephalitis, radionuclide studies have proven to be more sensitive than CT early in the infectious disease process. The present article describes a molecular-biological based method, which facilitated the broad-range analyses of bacterial communities in ixodid ticks (Ixodes ricinus). The manipulation of the interparticle interaction properties and the detection of the molecular signatures are two of the key elements in this concept. We found that particular AMPs are sex-specific and tightly regulated by the presence of a carcass or offspring and identified the two most context-dependent antimicrobial proteins in anal secretions. The results show that homicide-parasuicides constitute a different category of lethal violence with regard to demographic, individual, and event-related characteristics. 439 children and adolescents, their parents and adults with DSD participated.

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In most countries, CVD is the third most frequent cause of death, exceeded only by heart disease and cancer. The CaBP-preS1 fusion protein partitioned in the soluble fraction on heat treatment and this facilitated its rapid purification. Regression analyses were used to determine whether significant correlations existed between lesion scores and antibody responses to either whole outer membranes or to individual OMP. Twelve women with hypoestrogenic amenorrhoea and 13 eumenorrhoeic subjects (controls) were enrolled. Several threonine residues proximal to the CD8beta Ig headpiece are glycosylated with core-type 1 O-glycans. Our studies suggest that semen may play a critical role in providing the antigenic and environmental signals necessary to initiate an appropriate maternal immune response to the conceptus during pregnancy. These results demonstrate that regulation of endosomal acidification can be achieved, in part, through a Gi-mediated signal transduction pathway. To compare return to work (RTW) rates for patients who underwent single-level cervical fusion for radiculopathy compared with fusion for degenerative disc disease (DDD) as an indication for surgery. In addition to mite extracts, a recombinant major allergen of L. The serum creatinine level returned to that before withdrawal and proteinuria disappeared by steroid readministration.

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The active site copper in LPMOs is coordinated by a histidine-brace. Recently, we have reported the purification and cloning of a novel G protein betagamma subunit-activated phosphoinositide 3-kinase from pig neutrophils. Both axial clongation and scleral precursor synthesis are increased during form deprivation myopia (FDM). We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels. All the 3 patients were subsequently diagnosed with and successfully treated for symptomatic acetabular labral damage. Lower urinary tract implants or metastases from clear cell carcinoma of the kidney. Overexpression of p140mDia in COS-7 cells induced homogeneous actin filament formation. It is generally one the main causes of morbidity and mortality in the world, especially in developed countries. DQ alpha and beta and DR beta appear to be present as multicopy genes, while DR alpha-, DZ alpha-, and DO beta- like genes appear to be single copy.

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Enhancers increase the frequency of transcription initiation from linked promoter elements, most probably as a result of the binding of specific proteins to the enhancer. There was no significant difference in EVLWI, pulmonary shunt fraction, and time on mechanical ventilation. A number of challenges however exist to equipping academic, industrial and health agency staff with the requisite knowledge, skills and experience to develop the next generation of medicines. Cyclin D1 is required for S phase traversal in bovine tracheal myocytes. Quantitative high resolution in vitro 1H nuclear magnetic resonance spectroscopy was employed to study the metabolic effects of 3-nitropropionic acid associated with aging from perchloric acid extracts of rat striata. The urethral-fixation technique significantly improves early urinary continence recovery in comparison with the standard technique. Additionally, the metabolic demands of the newborn brain are still evolving.

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This enhancement was greater than that observed in the presence of the lignin peroxidase recycling agent veratryl alcohol. The relationship between a representative PDE4D genotype and ischemic stroke was explored in a case-control study of 205 consecutive Korean patients with noncardiogenic ischemic stroke and 103 healthy controls who were neurologically and radiologically proven to be stroke-free. Triple alpha genes in association with sickle cell and beta-thalassaemia gene in the Saudi population. Improved progression-free and overall survival in advanced ovarian cancer as a result of a change in surgical paradigm. Certain factors determining types of anomalous position of incisors. Thus, the p190 RhoGAP/ROCK pathway, which regulates the morphology of dendrites and axons during neural development, plays a central role, through a GRB2-mediated molecular complex, in fear memory formation in the lateral amygdala. We extend Chinese Restaurant Process (CRP) to TC-CRP, and further to Temporally Coherent Chinese Restaurant Franchise (TC-CRF) to jointly model entities and temporal segments using mixture components and sparse distributions. We have mapped several sites of that kind in vitro at one-base resolution but have focused our attention on one particularly stable conformational isomer which occurs approximately 270 base pairs upstream from the preferred transcription origin. A 31-year-old man with Marshall-Stickler syndrome was evaluated for a retinal vascular tumor. A common feature of these stimulation studies is that the facial expression was always accompanied by motor awareness and often by mirth, in line with the affective functions attributed to these regions.

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Adolescent drug use and adult drug problems in women: direct, interactive, and mediational effects. Hence, it is feasible to measure SMABF using TEE in patients undergoing cardiac surgery under hypothermic CPB. Using global genetic analysis, we evaluated how two commonly studied cell types, U937 and Jurkat, respond to nsEP exposure. To determine an optimal serum E(2) level on the day of hCG administration in controlled ovarian hyperstimulation (COH) during IVF-ET without compromising pregnancy outcome. As the incidence of preterm birth is increasing, there is now a growing population of adults whose mental health needs have been neglected. A series of experiments were subsequently performed in a mouse model of CAs. Acute surgical deformity correction causes in changes in soft tissue tension in the anterior neck, resulting in dysphagia. IgM levels decrease until negative a few weeks or months after acute infection, but individual and assay-related variability is common. Corrigendum: Determining Chemically and Spatially Resolved Atomic Profile of Low Contrast Interface Structure with High Resolution.

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Previously, we have shown that resveratrol suppresses the activation of the nuclear transcription factor NF-kappaB. Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. This receptor subtype has high affinity for GABA and produces a degree of tonic inhibition on cerebellar granule cells, modulating the firing of these cells via spillover of GABA from GABAergic synapses. Moreover, lives that are unpredictable from the perspective of an individual agent may become predictable when aggregated to the level of a societal decision. Therefore, a simple and relatively sensitive two-dimensional spin-echo difference experiment can be used to identify residues with a 3JN gamma coupling substantially larger than 1 Hz, indicative of a trans arrangement between N and C gamma. Infection with the nematode, Nippostrongylus brasiliensis, results in a Th2-dominated immune response. Data show a low prevalence of homosexuality/bisexuality, which can be a result of underreporting. MT1-MMP gene expression in cultured chondrocytes was induced by treatment with interleukin-1 alpha and/or tumor necrosis factor-alpha.

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The dedifferentiated adipocytes were induced for adipogenic, chondrogenic and osteogenic differentiation in specified media. Various strains of Burkholderia spp, strains of closely related genera, and spleen tissue samples of experimentally infected mice were investigated. Recent advances in the understanding of how the mind works is the result of painstaking research which has zetia dose range isolated tiny regions of the spinal cord and brain, and singular chemical pathways or responses to sole neurotransmitters. To evaluate the frequency and sites of communication between the lateral and medial synovial sacs of the metatarsophalangeal or metacarpophalangeal joints in cattle. No recombination was detected in the homeologous (1A(m)/1A) segments, irrespective of whether terminally or interstitially positioned in a chromosome, whereas the levels of recombination in the juxtaposed homologous (1A/1A) segments was normal or close to normal relative to completely homologous 1A chromosomes. Hitherto integrated process design has not been an option because the tools to predict in-sewer wastewater transformations have been inadequate. The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population. Differences in nutritional risk and nutrition-related behaviors in exercising and nonexercising rural elders. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.

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A number of bioactive constituents such as phenolic compounds, saponins, bioactive proteins, glycoalkaloids labetalol 100 mg tablet images , and phytic acids are responsible for the observed effects. Elevation in pulmonary neutrophils and prolonged production of pulmonary macrophage inflammatory protein-2 after burn injury with prior alcohol exposure. To evaluate the effect of auscultation, partial pressure of carbon dioxide in end-expiration (P(ET)CO2), transillumination technique to judge whether the endotracheal tube is misplaced into the esophagus. Then partial least squares regression was applied to construct a regression model to bridge the total ion chromatogram fingerprints and the antitumor activity of P. Notably, a structural abnormality of chromosome 17 was detected in the MPNST, and loss of chromosome 22 was detected in the MTT. For stimuli characterized by a steep (200-dB/oct) slope, it was found that the size of the FMDI depended on which cues were used for detecting the signal and masker modulations. The authors reviewed the medical records for previtrectomy and postvitrectomy lens changes in patients younger than 30 years of age at the Kellogg Eye Center, University of Michigan. This exacerbation of the already significant hemodynamic depression observed in infants during halothane anesthesia underscores the importance of adherence to published fasting guidelines.

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Well-timed sexuological counseling and openness of health care providers in sexual topics are very important parts of complex care of oncogynaecologic patients and their partners. The occurrence of systemic anaphylactic side-effects in the course of allergen-specific immunotherapy has been strongly reduced by the adsorption of allergens to aluminium hydroxide, the most frequently used adjuvant in humans. Several risk factors for ectopic pregnancy (EP) have been identified, but the site of implantation of EP has been little studied. Hydride transfer stereospecificity of rat liver aldehyde dehydrogenases. Two preparations of human chorionic gonadotropin extracted from pregnancy urine were used, one highly purified (National Institutes of Health, CR-121) and one less pure (Sigma). The subjects were instructed to work as if they were on an incentive basis, getting paid for the amount of work they performed. For the targeted therapy of solid tumor mediated by monoclonal antibody (mAb), there have different models of rebuilding small antibodies originated from native ones. SMANCS/Lipiodol was administered intraoperatively to eight patients with colorectal cancer and preoperatively to one patient with gastric cancer with lymph node metastases. The lipohilic/amphiphilic molecules that function as cellular activators or modulators of TRPC proteins span a wide range of chemical structures. The effects of estrogen replacement therapy on lipid and glucose metabolism as related to abdominal fat distribution were investigated in fifty-one healthy postmenopausal women aged 52-53 years.

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