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Amitryptyline

Amitryptyline is sometimes used off-label, meaning not FDA approved, for certain conditions. Some providers will use this medication to treat nerve pain. This can be helpful for people who have diabetes or fibromyalgia and haven't felt relief with other medications.

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Also known as: Amitriptyline

Description

Amitryptyline (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitryptyline is a prescription medicine used to treat symptoms of depression.

Dosage

Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitryptyline dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitryptyline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Amitryptyline if you are allergic to Amitryptyline components. Do not take Amitryptyline if you are pregnant, planning to become pregnant, or are breast-feeding. Be careful with Amitryptyline if you suffer from or have a history of a history of heart attack, stroke, bipolar disorder (manic-depression), schizophrenia or other mental illness, diabetes, overactive thyroid, glaucoma, problems with urination, heart disease, seizures. Be careful with Amitryptyline if you are taking guanethidine (Ismelin), disulfiram (Antabuse), heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), quinidine (Cardioquin, Quinidex, Quinaglute), cimetidine (Tagamet). Avoid alcohol. Be careful! Taking Amitryptyline you can become suicidal. Be careful when you are driving or operating machinery. Be careful with Amitryptyline if you are going to have a surgery. It can be dangerous to stop Amitryptyline taking suddenly.

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Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to drug-induced liver injury. Intestinal bacterial community is indicative for the healthy status of Litopenaeus vannamei. A 54-year-old female presented with a cerebral metastasis of functioning parathyroid carcinoma in the right occipital lobe. The results indicate that longitudinal bone loss around implants is correlated to previous experience of loss of periodontal bone support and that periodontitis susceptible subjects may show an increased implant failure rate. Besides bariatric surgery modern sleeve gastrectomy has one more so far largely neglected origin: segmental and later longitudinal gastric resection used in ulcer surgery. Mobility studies on the greater complement fixing particle and its splitting by pH-6.5. Their structures have been assigned on the basis of spectral studies.

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Comparing efficacy and safety of fibrinogen concentrate to cryoprecipitate in bleeding patients: a systematic review. The margin of resection was determined by pathological review and did not necessarily reflect operative margins. A matched case-controlled evaluation of 322 allogeneic patients from a single institution with a median follow-up of 296 and 120 days among nonobese and obese patients, respectively, was conducted between April 1983 and June 1995 at the University of Kentucky. Fish oil dietary supplementation for prevention of indomethacin induced gastric and small bowel toxicity in healthy volunteers. Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma. Comparison of liquid chromatography-ultraviolet and chromatography-tandem mass spectrometry for the determination of indapamide in human whole blood and their applications in bioequivalence studies. Skull traction was applied on admission in all patients and the dislocation as gradually reduced under sedation. Clinical features of multiple myeloma are linked with immunological phenotype of myeloma cells. During the second phase of the study, 108 patients had sentinel node excision and only those with positive nodes had completion axillary dissection.

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The Virtual Organ Computer-Aided Analysis program was used to evaluate the placental volume (PV), the placental quotient (PQ: placental volume/crown-rump length) and the vascular indices (vascularization index VI, flow index FI and vascularization-flow index VFI). The available evidence reviewed does not allow definitive response to the question of a primary versus secondary role of sex hormone perturbations in RA. DIA was consistently the least variable and most time-efficient method for assessing the magnitude of macrophage responses across lesions and between users. Conclusions from Ufa, Russia, drinking water dioxin cleanup experiments involving different treatment technologies. UK Renal Registry 18th Annual Report: Chapter 3 Demographic and Biochemistry Profile of Kidney Transplant Recipients in the UK in 2014: National and Centre-specific Analyses. The common standard deviation score of WHR/Ht can serve as an epidemiological index of body fat distribution adjusted for ages between 6 and 15 y. Our data suggest that immune response in hepatocellular carcinoma targets important proteins involved in cellular biosynthetic or proliferative functions. Simulation of elastic rupture in extension of entangled monodisperse polymer melts. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.

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