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Amitrim (Amitriptyline)
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Amitrim

Amitrim is a tricyclic antidepressant. Different doses of this medicine help in treating and preventing different problems such as depression, neuropathic pain, and migraine. Amitrim is normally taken before bedtime because it can make you feel sleepy.

Other names for this medication:
Abamax, Amiclozor, Amicon, Amitar, Amitone, Amitop, Amitrim, Amitrol, Amitwix, Amiwel, Amixide, Amoten, Amsha, Amtipax, Amtran, Amypres, Anitryp, Aptric, Arpidox, Axtrip, Bluneel, Cotrip, Crypton, Emotrip, Endep, Eptanol, Estiline, Libral, Librodep, Limbitrol, Limbival, Lodep, Maxitrip, Mitrip, Mitryp, Nextrip, Relidep, Ristryl, Sereval, Tablin, Teedep, Tridep, Tryline, Tryptomec, Typlin

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Also known as: Amitriptyline

Description

Amitrim (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitrim is a prescription medicine used to treat symptoms of depression.

Dosage

Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitrim dosage information

Overdose

If you overdose Amitrim and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Amitrim overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Amitrim if you are allergic to Amitrim components. Do not take Amitrim if you are pregnant, planning to become pregnant, or are breast-feeding. Be careful with Amitrim if you suffer from or have a history of a history of heart attack, stroke, bipolar disorder (manic-depression), schizophrenia or other mental illness, diabetes, overactive thyroid, glaucoma, problems with urination, heart disease, seizures. Be careful with Amitrim if you are taking guanethidine (Ismelin), disulfiram (Antabuse), heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), quinidine (Cardioquin, Quinidex, Quinaglute), cimetidine (Tagamet). Avoid alcohol. Be careful! Taking Amitrim you can become suicidal. Be careful when you are driving or operating machinery. Be careful with Amitrim if you are going to have a surgery. It can be dangerous to stop Amitrim taking suddenly.

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For example, by detecting where connection patterns change, one can define anatomical borders between cortical regions or subcortical nuclei in the living human brain for the first time. The inclusion behavior of cis-cyclooctene, cis, cis-1, 3-cyclooctadiene and cis, cis-1, 5-cyclooctadiene with beta-cyclodextrin (beta-CD) was studied by using (1)H NMR method in D(2)O/CD(3)OD solution and PM3 quantum-chemical simulation in vacuum. In a recent work it has been shown that in urodeles the activation of L-type calcium channels is sufficient to trigger neural induction. To elucidate contribution of left ventricular hypertrophy (LVH) vs myocardial ischemia to rhythmic disorders in patients with essential hypertension (EH) and LVH. Inducible NOS was constitutively expressed in the pregnant uterus (smooth muscle and epithelia) and placenta (sinusoids and macrophages) but was absent in the nonpregnant state as determined by RT-PCR and immunohistochemistry.

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Evaluation of a bioreactor with stacked sheet shaped organoids of primary hepatocytes. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. A retrospective review was performed in patients with biliary obstruction who underwent EUS-BD or PTBD after failed ERCP from June 2010 through December 2014 at a single tertiary care center. For amplification and detection of influenza RNA, all molecular assays evaluated were based on real-time PCR. Microbial metabolites emerge as key messengers in the complex communication between the gut microbiota and their host. Ion-damaged germanium shows a significant decrease in photoresponsivity with implant dose, particularly with doses exceeding the critical amorphizing dose (D(c) approximately 1 x 10(14) cm(-2)). Nonhealing wounds, necrotizing infections, radiation-induced necrosis, crush injury, decompression illness, and CO poisoning all exhibit impaired tissue oxygenation. EP4 receptor gene expression, on the other hand, was detected in the intestinal mucosal layer. PET in radiotherapy planning: particularly exquisite test or pending and experimental tool?. Increased expression of ALDH1, EZH2 and KI67 are found to be associated with unfavourable prognosis in patients with astrocytic gliomas and may predict therapeutic modalities.

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Women of child-bearing age are at especially high risk for iron deficiency due to ongoing menstrual blood losses. Salmonid alphavirus associated with Lepeophtheirus salmonis (Copepoda: Caligidae) from Atlantic salmon, Salmo salar L. Circulating monocytes and dendritic cells were analyzed by flow cytometry for quantity, phenotype, activation status, human leukocyte antigen DR (HLA-DR) expression, and toll-like receptor-2 and -4 expression. In a nested cohort of women receiving infertility treatment, we determined if such risk rests predominantly with certain causes of infertility. A long-term study of durability and risk factors for aneurysm recurrence after microsurgical clip ligation. The experimental data revealed that both the Langmuir and Freundlich isotherm models fitted well with the fluoride sorption process. Here, we report the identification of human Sonic Hedgehog (SHH) as HPE3-the first known gene to cause HPE. The zinc content in almost all rat tissues remarkably increased with a conspicuous decrease of copper and various changes of iron at doses of 600 mg/kg/day or more. We conclude that long-term effects of CRF and VIP in neurons are likely to be mediated by the transcriptional regulation of CRF and VIP-responsive genes via the cAMP signaling pathway.

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Our objective is to show that the understanding of disaster preparedness on multiple levels, including government, hospital, ICU, and clinician, may lead to optimal management in a disaster. In these models the role of joint loading in the development of OA is not fully understood. Serum IgA anti-tissue transglutaminase antibody titres (measured by ELISA), IgA anti-gliadin antibody titres (measured by a commercial ELISA) and anti-endomysial antibody titres (measured by indirect immunofluorescence) were determined in 46 untreated and 14 treated patients biopsy-proven coeliac disease and 145 disease and healthy controls. A novel 3-stage classification of actinic conjunctivitis, devised by one of the authors, was used to stage the disease. Instrumental diagnosis of obstructive jaundice: brushing versus biopsy. Cellular spreading on NCAM-F3 substratum was selectively increased in fibroblasts expressing transmembrane NCAM, and only the NCAM-F3 fusion protein lacking the proline-rich insert was able to elicit this effect. What happened to the innovation and competition Zarxio was supposed to spark?. NO production from some source may be reduced with aging, as indicated by falls in 24-h NOX excretion, although the similarity in pressor response and enhanced renal vasoconstrictor response to NOSI suggests that the role of NO in control of total peripheral and renal vascular resistance is maintained. In contrast, even a 200-fold CB3717-resistant subline developed in leucovorin (MOLT-3/CB3717(200)-LV) showed neither amplification nor overexpression of the TS gene.

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Development of a flow cytometry assay for the identification and differentiation of chemicals with the potential to elicit irritation, IgE-mediated, or T cell-mediated hypersensitivity responses. The testes in different groups of whitethroated munia (Lonchura malabarica) were studied following exogenous treatment of testosterone propionate (1 mg/100 g body wt./day) at 06.00 h or 14.00 h or 22.00 h for 15 consecutive days during the quiescent phase of the annual testicular cycle. Modifiable Risk Factors in Total Joint Arthroplasty: A Pilot Study. The incubation of total cellular RNA and nuclear DNA isolated from lymphocytes with CrCl3 and K2Cr2O7 yielded a binding of 1.1-1.6 fold more of Cr atoms to RNA than to DNA. In this compartment, both spectrin forms may be metabolized in vivo, at least in part, by calcium-activated proteolysis. This study tested a convenient way to increase PA among type 2 diabetes patients. The Francis method was used to detect data saturation and thereby identify sample size. Thus, these structures support only a T left and right arrow R left and right arrow R2 allosteric pathway and underscore the physiological importance of the R2 conformation. Targeted interventions may be necessary to improve infant feeding practices in mothers who reside in urban areas, are more educated, and are from wealthier households.

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A 54-year-old female with chronic hepatitis C developed severe thrombocytopenia after a single administration of Peg-IFN alpha 2a subsequent to 48 weeks of Peg-IFN alpha-2b plus ribavirin therapy. Many studies have demonstrated that honey has antibacterial activity in vitro, and a small number of clinical case studies have shown that application of honey to severely infected cutaneous wounds is capable of clearing infection from the wound and improving tissue healing. Supramolecular vs Electronic Structure: The Effect of the Tilt Angle of the Active Group in the Performance of a Molecular Diode. The Ten Most Commonly Asked Questions about Platelet Glycoprotein IIb/IIIa Receptor Antagonists. To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats. Taken together, the data suggest that GM-CSF could upregulate the LTR-driven transcription of HIV-1 through modulation of NF-kappaB and SP1 by multiple signalling pathways. Three HPLC peaks were found to be immunoreactive, in hemolymph extracts of both sexes. Because hydrodynamic friction takes place at the molecular surface, another possibility is to use shell models, as originally proposed by Bloomfield.

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We tested the hypothesis that a specific viral protein prevents type I IFN signaling by targeting signal transducer and activator of transcription-1 (STAT1). The Value of Long-Term Stream Invertebrate Data Collected by Citizen Scientists. Cycling on a recumbent ergometer constitutes one of the most popular rehabilitation exercises in cerebral palsy (CP). The present work contributes to the understanding of DuCV molecular epidemiology. The mean prescribed Kt/V did not differ from mean Kt/Vd when IDPN was withheld. Furthermore, it could also be used for image guided robotic interventional procedures inside a MRI system if so desired. The anti-tumor immunity of Newcastle disease virus HN protein is influenced by differential subcellular targeting. Electrochemistry-on-chip for on-line conversions in drug metabolism studies. Conversely, those with normal baseline RV function demonstrated LVEF increases that were not observed in patients with RV dysfunction.

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Changes in the incidence and duration of periods without insurance. Twenty-eight New Zealand rabbits were randomly separated into four groups. An inhibition of transcription by alpha-amanitin did not block the Csb-dependent repair in ogg1(-/-) fibroblasts. Localization of retina/pineal-expressed sequences: identification of novel candidate genes for inherited retinal disorders. The Medpor implant was shaped precisely based on the deficiency model and implanted with dermis-fat graft at the same stage. Interrater agreement in the measurement of QRS interval in tramadol p tablet uses in tamil tricyclic antidepressant overdose: implications for monitoring and research. The results show how the parameters measured with the functional techniques (fluorophotometry, pachymetry) generally become normal after the surgical trauma, while the endothelial cell count remains irreversibly altered.

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Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. Phase-resolved two-dimensional spectroscopy based on collinear n-wave mixing in the ultrafast time domain. cDNA clones encoding six cytosolic small heat shock proteins (sHSPs) were identified using differential screening. To ascertain whether laminitis can be induced via administration of oligofructose (OF) at doses of 5.0 and 7.5 g/kg in horses and to assess glucose and insulin dynamics before and after treatment. The simple and relatively inexpensive method presented herein allows for convenient analysis of sequence variation in DRD5 and can be easily adapted to other duplicated genomic regions in order to obtain good quality sequence data. This provides more diagnostic information concerning acute myocardial infarction and other muscle diseases than is available from routine CK isoenzyme analysis.

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Cerebellar activation during classical conditioning of the human flexion reflex: a PET study. Here, we show that Xdpcp (Xenopus dok-PTB containing protein) has a pivotal role in regulating mesendoderm formation in Xenopus, and negatively regulates the activin/nodal signaling pathway. In addition, apoptotic molecules may serve as surrogate molecular markers of tumor response to IL-13R-directed cytotoxin therapy. Modifications on Tyr-3 or/and Tyr-63 of PLA2 resulted in the complete loss of its ability to enhance the ANS fluorescence. The optimal diagnostic excitation wavelengths identified using this model - 350-370 nm excitation and 400-450 nm excitation - are similar to those identified for detection of human oral cavity neoplasia.

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