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Alprostadil

Alprostadil is used to treat erectile dysfunction (ED). This medicine helps to create and maintain an erection. Alprostadil should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Description

Alprostadil, like its contemporaries Edex, Muse and Caverjet, is an impotence agent and vasodilator known as prostaglandin E1. Alprostadil is usually used by men when the blood vessels, nerves and muscles in the penis do not work properly. This unique medication treats every type of erectile dysfunction - vasculogenic, psychogenic, mixed and neurogenic etiology. The prostaglandin E1 relaxes the blood vessels and thins the blood, delivering blood flow to the penile area and causing a hard erection. The main advantage of Alprostadil is its quick action, just 5-10 minutes after injection. The effects last for 30-60 minutes but may vary slightly from patient to patient. Alprostadil doesn't protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Dosage

Use Alprostadil exactly as directed by your doctor. Do not use more of it, do not use it more often or longer than your doctor ordered.

Alprostadil comes with patient directions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Alprostadil usually begins to work in about 5 to 10 minutes. You should attempt intercourse within 10 to 30 minutes after using the medicine. An erection may continue after ejaculation.

To use:

Before inserting a suppository, you should urinate. The small amount of urine normally left in your urethra will help dissolve the suppository after it is inserted. Remove the delivery device containing the suppository from the foil. Remove the cap from the applicator stem. Stretch your penis upward to extend its length, pressing your penis top and bottom. Gently insert the delivery stem up to its collar into your urethra (located at the top of the penis). If you have pain or a pulling feeling in the penis, withdraw the device and start again. Press the button down slowly as far as it will go. This releases the suppository into the urethra. After holding the delivery device within your penis still for 5 seconds, carefully rock the penis and delivery device as a unit from side to side. This helps remove the suppository from the device. Remove the delivery device while your penis is upright. Look at the device to make sure that the suppository was completely released. Repeat the process if a part of the suppository remains in the device. After the suppository is completely released, roll your penis between your hands for 10 seconds. This helps to dissolve the suppository. If you feel any stinging, continue this motion to help stop it. Sitting, standing, or walking for 10 minutes while an erection is developing helps increase the blood flow to your penis to gain a proper erection. Replace the cap on the delivery device. After storing it in the foil, fold and throw away.

The dose of Alprostadil will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Alprostadil. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For urethral dosage form (suppositories): For erectile dysfunction: Adults—One suppository inserted into the urethra once a day, 10 to 30 minutes before sexual intercourse. Do not use more than 2 suppositories each day. Children—Use is not recommended.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, painful/prolonged erection.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Alprostadil for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for 3 months. After it is mixed, the solution must be used immediately or within 24 hours and not refrigerated or frozen. Suppositories may be stored at room temperature.

Detailed Alprostadil dosage information

Side effects

The most common side effects associated with Alprostadil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before using alprostadil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: genito-urinary tract disorder (e. g. , urethral stricture/obstruction, urethritis, inflammation/infection of the head of the penis), indwelling urethral catheter. Before using this medication, tell your doctor or pharmacist your medical history, especially of: penis conditions (e. g. , angulation, cavernosal fibrosis, Peyronie's disease), bleeding disorders, blood system cancers (e. g. , leukemia, multiple myeloma), heart disease, low blood pressure, sickle cell anemia. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Use of this drug does not protect against sexually transmitted diseases (e. g. , HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method such as a latex or polyurethane condom during all sexual activity. Consult your doctor or pharmacist for more details. This medication is not for use in women. If this drug is used by a male for sexual intercourse with a pregnant woman, an effective barrier method such as a latex or polyurethane condom should be used. Consult your doctor or pharmacist for more details.

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