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Alprasert (Alprazolam)

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Alprasert is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alprasert, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alprasert is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
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Similar Products:
Ventolin, Hydrea, Sinequan, Avapro, Clarinex, Dytide, Veega, Albenzole, Epsoval, Lanoxin, Proventil, Formador, Enxolam, Noworm,

Also known as: Alprazolam


Alprasert XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Alprasert XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Alprasert XR may also be used for other purposes not listed in this medication guide.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprasert XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprasert dosage information

Side effects

The most common side effects associated with Alprasert are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Alprasert if you are pregnant. It could harm the unborn baby.

Do not use this medication if you are allergic to Alprasert or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before you take Alprasert, tell your doctor if you have asthma or other breathing problems, glaucoma, kidney or liver disease, a history of alcoholism, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Do not drink alcohol while taking Alprasert. This medication can increase the effects of alcohol.

Alprasert may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

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Young children in low- and middle-income countries frequently have inadequate vitamin B-12 (cobalamin) status. NADH measurements in adult rat myocytes during simulated ischemia. Subtle vitamin-B12 deficiency and psychiatry: a largely unnoticed but devastating relationship?. We observed that FITC-labeled protein nanoparticles were internalized by the cells mainly through Arf6-dependent endocytosis and Rab34-mediated micropinocytosis. Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer. We treated 3 patients with this technique, and all had immediate pain relief. In immunotherapy of the MCA205 sarcoma, administration of the neutralizing anti-IL-12 mAb nearly completely blocked the adjuvant effect of IL-12, but had minimal inhibitory effects on anti-OX-40R mAb. At 6 hours after endotoxin injection, the lung revealed diffuse alveolar damage-sparing type II cells which appeared resistant to injury but more mature than type II cells from control lungs. Family-centered outcomes during and after critical illness: current outcomes and opportunities for future investigation. Cytokine levels in serum were determined using Luminex or ELISA.

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We examined the clinical outcome of patients undergoing a unicompartmental knee replacement (UKR) in an accelerated care program (A group) compared to a conventional care program (C group). Results of computational analyses of binding properties of several representative metabolites to homology models of fungal proteins are presented. Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. Until recently the therapy of this disease was frustrating and often based only on supportive care. Impact of human papillomavirus vaccination depends on effective vaccination strategy. In addition, FIP1 mRNA was down-regulated in the suppressor of phytochrome A-105 1 mutant and differentially expressed in constitutive photomorphogenic 1-4 (cop1-4) and cop1-5 mutants under cFR. Percutaneous guided biopsy is very useful in hematological patients, especially those with malignant lymphomas. Finally, we will speculate about whether something has changed in the can you drink alcohol while taking plavix last few years that might finally bend the curve and reverse the trend of a steadily rising preterm birth rate. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Analysis of two isomeric cyclic hexapeptides of composition (Asp, Arg, Gly2, Pro, D-Pro) by a nuclear Overhauser effect constrained distance geometry conformation search yielded a narrowly defined backbone conformation for one and considerable ambiguity about the conformation in part of the other.

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A simpler method, termed single-step GBLUP, or ssGBLUP, integrates the genomically derived relationships (G) with population-based pedigree relationships (A) into a combined relationship matrix (H) and allows for genomic selection in a single step. This variability can stem, at least in part, from the modulating effects steroid and non-steroid hormones exert on prevacid generic names olfactory processing. These antigens are strongly expressed on neoplastic B lymphocytes but not on thymocytes or a cultured T-cell line. The performance over 10 trials was analyzed in terms of algebraic, absolute, and variable error. Evaluation of playground injuries based on ICD, E codes, international classification of external cause of injury codes (ICECI), and abbreviated injury scale coding systems. We conclude that concurrent magnesium administration with Pabrinex may be required for enabling full efficacy of Pabrinex treatment, as demonstrated by its positive effect on erythrocyte transketolase activity.

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The inhibitory effect of c-myb antisense oligodeoxynucleotides (ODNs) conjugated to folic acid (FA) on HL-60 cell proliferation was examined. MR imaging in the diagnosis of denervated and reinnervated skeletal muscles: experimental study in rats. SH2B2beta markedly attenuated the ability of SH2B1 to promote JAK2 activation and subsequent tyrosine phosphorylation of insulin receptor substrate-1 by JAK2. Salter-Harris type II proximal humerus injuries: our experience with a new external fixator. Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins. Woodchuck hepatitis virus X protein is required for viral infection in vivo. These analyses have identified two genes that are strongly developmentally light regulated, expressed predominantly in photosynthetic tissue, and with transcript abundance peaking before dawn. The purpose of this study is to analyze the results of intramedullary fixation of pathological humeral shaft fractures using an unreamed humeral nail (UHN). Selective internal radiation therapy for liver metastases from colorectal cancer. This was a 52-week, randomized, double-blind, multinational study of ccHRT comprising three different dose combinations of E2V/MPA in 459 early postmenopausal non-hysterectomized women experiencing 30 or more moderate to severe hot flushes a week and/or vasomotor symptoms requiring treatment.

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Here, I review developmental and cross-cultural studies on the affective character of musical modes, concluding that while learning clearly plays a role, the emotional associations we make are (1) not arbitrary, and (2) best understood by also taking into account the physical characteristics and biological purposes of vocalization. Relevant studies were those that described the safety and/or effectiveness of minimally invasive anterior or lateral LIF (LLIF), transforaminal LIF (TLIF), and decompression only. Therefore, existing early interventions that target JE behaviors may be effective for promoting language, social communication, and social interaction in this population. Initial development and in vitro evaluation of the HPL device for obtaining reproducible bitewing radiographs of children. Using gain- and loss-of-function approaches in mice, we discovered that class II HDAC proteins suppress the formation of slow twitch, oxidative myofibers through the repression of MEF2 activity. There are two major challenges in calling OTUs: identifying bacterial population boundaries and differentiating true diversity from sequencing errors.

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Increasing patient census and department overcrowding are universal concerns in pediatric emergency medicine. When performed with careful regard to confounding factors, measurement of the aldosterone : renin ratio in all hypertensive individuals, followed by fludrocortisone suppression testing to confirm or exclude primary aldosteronism and adrenal venous sampling to determine the subtype, can result in the detection of significant numbers of patients with specifically treatable or potentially curable hypertension. We show that the anti-c-MET Nanobody effectively inhibited thymidine incorporation of ANBL-6 MM cells via inhibition of an HGF autocrine growth loop and thymidine incorporation in INA-6 MM cells induced by exogenous HGF. Notably, CARBs are distinct from the previously described luminal castration-resistant Nkx3.1-expressing cells (CARNs). Computed tomographic image of an inflammatory fibroid polyp of the stomach. Correlation of patient-reported symptom outcomes and treadmill test outcomes after treatment for aortoiliac claudication. Database searches revealed 118 amino acid sequences from self-proteins eluted from MHC I molecules and 191 from MHC II molecules, corresponding to 174 identified source proteins. Pretreatment of 2,4-dinitroanisole (DNAN) producing wastewater using a combined zero-valent iron (ZVI) reduction and Fenton oxidation process.

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The expansion in understanding the molecular biology that characterizes cancer cells has led to the rapid development of new agents to target important molecular pathways associated with aberrant activation or suppression of cellular signal transduction pathways involved in gliomagenesis, including epidermal growth factor receptor, vascular endothelial growth factor receptor, mammalian target of rapamycin, and integrins signaling pathways. Optic nerve topography and dimensions show inter-personal variations that may be anticipated to some extent with cranial anthropometric data. A group of 203 participants completed self-report questionnaires measuring meaning of illness, problem-focused coping, social support, psychological well-being, and depressed mood. Hyperparasitaemia and phagocytosis of Plasmodium falciparum in fatal cerebral malaria. Analysis of the levels of mRNA, protein, and activity for tyrosine hydroxylase demonstrated that the LC neurons survive the injury while the SNc neurons degenerate. A major pathogen of potato plants (Solanum tuberosum) is the potato cyst nematode (Globodera provera to induce period dosage spp.), which induces localized redifferentiation of a limited number of host cells to form a specialized feeding-site termed the syncytium. Reflections on Darwinian Evolution - Is there a Jewish Perspective?. Surgical treatment of tibial spine fractures offers the possibility to regain full stability of the knee joint and good long-term results after open reduction and internal fixation with low infection rates.

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GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes. Structure, distribution, and functional expression of the phosphofructokinase C isozyme. However, the electrochemistry of single-layer graphene has not yet been well understood, possibly due to the technical difficulties in handling individual graphene sheet. A slight but significant alteration of lung function has been observed. The right udder halves of the animals were inoculated through the teat canal with 1 ml of Mycoplasma ovine/caprine serogroup 11 (2-D) culture containing 6x10(6) colony forming units ml-1. Stroke patients think about goals very differently from health professionals.

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Serum HBV DNA levels evaluated by sensitive quantitative PCR assays can be used for differentiation between HBeAg-negative chronic hepatitis B and inactive hepatitis B surface antigen carrier state, but the cut-off level should be set at approximately 30,000 copies/ml and certainly lower than the recently suggested level of 100,000 copies/ml. Those that have been found to have the greatest activity against M. These findings indicate that the main route of viral spread in intraocularly inoculated mice is the trigeminal and oculomotor nerves and that the virus in the trigeminal nerve may trigger pruritus. Risk factors and prognostic variables in transient ischemic attacks and in infarctions with minimal sequelae. The integral dose delivered to a volume of interest is the total energy albenza generic deposited in that volume.

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Mitochondria-targeted apoptosis in human cytomegalovirus-infected cells. Assessment of the estrogenic activity of phytoestrogens isolated from bourbon and beer. The entire urogenital tract could be exposed and easily manipulated through this approach. The concentrations of free amino acid and protein-bound amino acid in gastric and colon cancers and also in normal tissues were measured and compared in order to investigate the differences in amino acid metabolism between these cancers. Physical activity and sedentary behavior in middle and older ages were not associated with ovarian cancer risk.

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