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Alpostin (Alprostadil)

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Alpostin is a medication used to treat erectile dysfunction. Alpostin (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of Alpostin on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Also known as: Alprostadil


Alpostin, like its contemporaries Edex, Muse and Caverjet, is an impotence agent and vasodilator known as prostaglandin E1. Alpostin is usually used by men when the blood vessels, nerves and muscles in the penis do not work properly. This unique medication treats every type of erectile dysfunction - vasculogenic, psychogenic, mixed and neurogenic etiology. The prostaglandin E1 relaxes the blood vessels and thins the blood, delivering blood flow to the penile area and causing a hard erection. The main advantage of Alpostin is its quick action, just 5-10 minutes after injection. The effects last for 30-60 minutes but may vary slightly from patient to patient. Alpostin doesn't protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the treatment of erectile dysfunction:
    • For injection dosage form:
      • Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Your exact dose will be determined by your doctor. Inject this medicine very slowly into your penis as shown to you by your doctor 10 to 30 minutes before intercourse. Allow 5 to 10 seconds to completely inject the dose. Do not inject more than one dose within 24 hours. Also, do not use this medicine for more than 2 days in a row or more than 3 times a week.


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Alpostin for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for 3 months. After it is mixed, the solution must be used immediately or within 24 hours and not refrigerated or frozen. Suppositories may be stored at room temperature.

Detailed Alpostin dosage information

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The most common side effects associated with Alpostin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Alpostin if you are allergic to any of its components or to other prostaglandins. Do not take Alpostin if you have blood problems such as sickle cell anemia or sickle cell trait, leukemia. You should not be treated with Alpostin injection if you have penile implants. Do not take Alpostin if you have penile problems, e.g. a curved or deformed penis. Do not use Alpostin if you have multiple myeloma or other bone marrow problems. Do not take Alpostin if you take other medicines for the treatment of erectile problems. Consult your doctor or health care professional immediately if the erection lasts longer than 4 hours or if it becomes painful. Alpostin is not a protector from sexually transmitted diseases or pregnancy. Avoid having unprotected sex. Do not share drug needles. Do not drive or operate machinery while taking the medication. Avoid consuming alcohol as it may worsen the medication side effects. Alpostin does not protect you and your partner from sexually transmitted diseases and pregnancy. Alpostin is not for use in women, children or newborns.

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