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Alfacalcirol (Calcitriol)
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Alfacalcirol

Alfacalcirol is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Alfacalcirol is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Alcee, Alfabond, Alfacip, Alphadol, Arcium, Biocal, Biocitral, Calbovic, Calcigra, Calcirol, Calcit, Calcitriol, Calcor, Caldix, Calfa, Calgel, Calotec, Caltop, Calzem, Carcal, Citroj, Coecoral, Dmcal, Fovit, Koncal, Netxod, Novadee, Nutribone, Ostonex, Refirm, Rical, Riecal, Rockbon, Roical, Rolsical, Romical, Solbiocal, Statbone, Sunmic, Tobalt, Trolec, Vezocal, Zaxial

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Neurontin, Imodium, Parlodel, Lopid, Zofran, Rocaltrol, Terramycin, Glucotrol, Differin, Rebetol, Permarid, Mycort, Conducil, Chloramsone, Amlosafe, Nifehexal, Minroset, Durogest, Provas,

Also known as: Calcitriol

Description

Generic Alfacalcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacalcirol are intestine and bone. Generic Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacalcirol may also act on the kidney and the parathyroid glands. Generic Alfacalcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacalcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacalcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacalcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacalcirol produces other independent beneficial effects. Alfacalcirol is also known as Calcitriol. Generic Alfacalcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacalcirol is Calcitriol. Brand name of Generic Alfacalcirol is Alfacalcirol.

Dosage

Generic Alfacalcirol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacalcirol suddenly.

Overdose

If you overdose Generic Alfacalcirol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacalcirol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome. Both gI and diflucan dose yeast vaginal gB antibodies were detected in the serum samples collected from chickens at different times postchallenge, indicating that the combination of these ELISAs was suitable to screen serum samples from chickens vaccinated with either recombinant viral vector FP-LT or HVT-LT vaccines. They contribute to the differentiation/proliferation/mobilization of endothelial progenitor cells from the bone-marrow. Scientific knowledge is possible with small-sample classification. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults. The photoaffinity labeling technique allows for a quick and efficient means of identifying nonviable cells which cannot be distinguished on the basis of light-scattering properties. Metastatic serous adenocarcinoma arising in the adnexa uteri and forming pleural cysts on the diaphragmatic pleura. It has shown to be more reproducible than conventional pressure measurement. Concentrations of weathered fuel oil greater than 1000 ppm were directly toxic to adults, while those of 100 to 200 ppm were toxic to juveniles. The limited comparative data suggested that EMLP caused fewer adverse postoperative outcomes but was more likely to generate a perioperative cerebrospinal fluid leak than OPF.

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