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Adefin (Nifedipine)

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Adefin is a drug that performs by relaxing the muscles inside the heart and blood vessels in order to enable easier blood flow. This enables the heart to have an easier time pumping blood. The active ingredient is nifedipine and it a part of a class of drugs called calcium channel blockers. The primary use of this medication is to help stop chest pain (angina) and help treat high blood pressure problems (hypertension). In addition to this it can also be used in order to heighten the supply of oxygen and blood to the heart and help with a specific blood circulation condition called Raynaud’s phenomenon.

Other names for this medication:
Adalate, Addos, Adipine, Atenerate, Calchan, Calcheck, Calcibloc, Carditas, Cardules, Conducil, Cordafen, Cordaflex, Cordalat, Cordilat, Cordipin, Duranifin, Ficard, Glopir, Macorel, Myogard, Nedipin, Nidilat, Nifatenol, Nifecard, Nifedalat, Nifedate, Nifedigel, Nifedin, Nifedip, Nifedipin, Nifedipina, Nifedipinum, Nifedipress, Nifehexal, Nifelat, Nifelong, Nifeslow, Nifestad, Nifezzard, Nifical, Noviken, Ospocard, Pressolat, Tensopin, Valni, Vasdalat, Viscard, Xepalat, Zenusin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


Adefin should be taken orally with or without food. It is better to take Adefin at the same time every day. Take on an empty stomach. Avoid grapefruit juice during treatment with Adefin. If you want to achieve most effective results do not stop taking Adefin suddenly.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Adefin dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Two evaluations following the didactic session and the small and large group sessions elicited information on satisfaction with each of the formats, self-reported change in stress, awareness of interpersonal and sociopolitical issues affecting Black women in the labor force, assessing support networks, and usefulness of specific discussion topics to stress reduction. Data Linkage from Clinical to Study Databases via an R Data Warehouse User Interface. Factors that are uncontrollable at the field scale, such as temperature and inflow water chemistry, may result in more complex and resilient microbial communities that are less specialized for denitrification. Patients with diabetes and peripheral neuropathy are at higher risk for falls. We have investigated the role of PACT and PKR in articular cartilage degradation using cytokine treatment of bovine primary chondrocytes and cartilage explants. Genetic evidence suggests that the Bacillus subtilis recF gene product is involved in DNA repair and recombination.

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The impact of anticipatory grief on caregiver burden in dementia caregivers. Public health education and improved access to voluntary medical male circumcision services may help to prevent this practice. Understanding blood pressure (BP) and volume changes during UF may eliminate intradialytic hypotension and cramps. It provides consumers with choices and information about those choices. Compared with the control rats, the cancellous and compact bone volume of the model rats were reduced markedly. Ecotoxicological effects of rice field waters on selected planktonic species: comparison between conventional and organic farming. Our goal is to develop a new tool for functional prediction (e.g., prediction of Enzyme Commission number), which can be used to complement and support other techniques based on sequence or structure information. Determination of cocaine and its metabolites in serum microsamples by high-performance liquid chromatography and its application to pharmacokinetics in rats. Forty-two calculi were extracted through the external urethral meatus. Hospitalizations Related To Opioid Abuse/Dependence And Associated Serious Infections Increased Sharply, 2002-12.

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Photodynamic therapy for bladder cancer: ethics of a collaborative trial in China. The tumors were 0.5 to 13.5 cm in diameter and located an average of 6.9 cm (range, 1 to 15 cm) from the anal verge. Great variation was seen in the protein and antigenic patterns induced by the different media. In contrast, antibiotics inhibited bacterial growth, but allowed fungal proliferation. Local activation therapy by massage in chronic marginal periodontal diseases.

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The Delta(8) desaturated products co-eluted with known Delta(8)-desaturated phytosphingenine and the molecular mass of these products was confirmed by liquid chromatography-MS. DNA from all 269 subjects was genotyped for D7S1875 repeat polymorphism in the promoter region of Leptin (LEP) gene using polymerase chain reaction. The addition of radiotherapy to the primary tumor and mediastinum failed to modify the autopsy distribution of residual tumor compared with that in patients treated with chemotherapy alone. To explore this hypothesis, we analyzed the expression of HS and heparan sulfate proteoglycan (HSPG) in histological sections of human lung-cancer tissues and assayed for the presence of HSPGs in extracts of human lung-cancer cell lines, using a panel of native HS-, delta-HS- and HSPG (syndecan, glypican, CD44 and perlecan) core protein-specific monoclonal antibodies. Investigation of additional potentially important neurotransmitter receptors, such as the opioid and cannabinoid receptors, may result in further improvements in antiemetic control and quality of life in coming years. Acute versus chronic functional aspects of unilateral spatial neglect. For endoscopic thoraco-lumbar spine fusion, CO2 thoraco-retroperitoneum-induced cardiopulmonary dysfunction must be of concern, especially in patients with cardiopulmonary compromise. Magnesium concentration in blood serum and cerebrospinal fluid (CSF) was determined in 131 patients aged from 21 to 91 years, with RIND, complete stroke, cerebral haemorrhage and control group.

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Sensitivity of frozen sections could be lowered if the preoperative axillary ultrasound examination becomes a routine, which would question its value. The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites. 4-CmC is a preservative within a large number of commercially available drug-preparations (e.g., insulin, heparin, succinylcholine), and it has been suggested that 4-CmC might trigger malignant hyperthermia. All 13 patients with pelvic pain and 5 with symptoms of autonomic dysreflexia noticed significant improvement if not complete resolution of the symptoms. Endogenous nitric oxide in exhaled air from patients with liver cirrhosis. The aim of this study was to examine the association between transformational leadership and depressive symptoms in employees working within healthcare. Specifically, we find that mathematical models show that allosteric proteins can respond to stimuli on a logarithmic scale. Synthesis, characterization and cytotoxicity studies of palladium(II)-proflavine complexes. Clinically, reactive intraparotid lymph nodes and lymphomas present as parotid enlargements that are indistinguishable from pleomorphic adenomas. Decreased susceptibility of low-density lipoproteins to in-vitro oxidation after dextran-sulfate LDL-apheresis treatment.

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Identification and stabilization of concomitant clinical problems by internal medicine specialists may safely decrease time to surgery in frail subjects with hip fracture. One case of transitory hyperesthesia and pain when sleeping on the operated site was observed. In athymic mice bearing the PANC-1 human pancreatic tumors, intratumoral injections of Ad-ING4 suppressed the tumor growth, downregulated CD34 expression, and reduced the tumor microvessel formation. It is imperative that the restorative dentist be aware of the perils of such inter-arch relationships. Seven of 12 patients included in the study completed the 8-month follow-up period. The Inflammatory Bowel Disease Specialty Medical Home: A New Model of Patient-centered Care.

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Radiation-induced solid cancer begins to appear at later ages than such cancer is normally prone to develop, and continues to increase proportionally with the increase in mortality or incidence in the control group as it ages. More knowledge about food contaminants can also help understand their inactivation. The best set was found by backward stepwise selection and the effect of every excluded variable on the binary classification cut-off points of the remaining variables was checked and corrected when needed. The downregulation of Hsp90 beta mediated by caspase-8-dependent caspase-10 activation promoted UVB-induced cell apoptosis. However, this transfer depends on the different binding forms of heavy metals. Thus, we propose a specific role of TRPC1 in the EDHF-K(Ca) signalling complex and suggest that pharmacological inhibition of TRPC1, by enhancing is 80mg of lipitor a high dose EDHF vasodilatations, may be a novel strategy for lowering blood pressure. Therefore, in this study we proposed to investigate whether plasma fibrinogen is associated with the patency of saphenous vein graft in patients at least 1 year after coronary artery bypass graft (CABG) surgery. NO synthase (NOS)-like immunoreactivity (IR) was found in the photocytes (photogenic cells) of the photophores. The oscillatory behavior can exhibit intrinsic frequency modulation and can be altered by synaptic processes.

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The clinical, administrative, research and educational, decision-making and quality improvement information needs of the department are served by the system. However, the same inhibitor showed no ability to modify expression patterns in pea carpels around the anthesis stage, suggesting different controls for ethylene synthesis and sensitivity in different flower organs. This observation provides further support for the conclusion that these ultrastructurally distinct mammary cells represent the mammary stem/progenitor cell population. By comparing copy number between pre- and post-treatment, we found significant copy number changes in 34 genomic loci. BRS and low-frequency component of HR variability were determined independently by the number of surgical procedures. There was marked uptake of both tracers in the mediastinum, which at surgery was confirmed to be an extrathyroidal parathyroid adenoma. Zoledronate and Molecular Iodine Cause Synergistic Cell Death in Triple Negative Breast Cancer through Endoplasmic Reticulum Stress. The histologic hallmark is the accumulation of mucin in the follicular epithelium, called follicular mucinosis. Transsexualism is considered to be the extreme end of the spectrum of gender identity disorders characterized by, among other things, a pursuit of sex reassignment surgery (SRS). Distribution pattern of human papilloma virus 16 genome in cervical neoplasia by molecular in situ hybridization of tissue sections.

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To summarize available data concerning pathophysiology and management of preterm labour and their use in clinical practice. Thermal manipulation affects mast cell number (MCN): high temperature decreased MCN in both January and May, while low temperature increased MCN only in January. The results also showed the potential of Saccharomyces cerevisiae as a model organism in studying the capacity of ATOX1 as a therapeutic target for lung cancer therapy. The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks. Postoperative alpha 2-adrenergic stimulation attenuates protein catabolism: effects of clonidine on growth hormone secretion. Furthermore, the degree of left DTD dilation may be associated with the severity of LC. Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1/2 MAP kinase. The described methodologies constitute an important step towards cost-effective in vivo production of conjugate vaccines, which in future may be used for combating severe infectious diseases, particularly in developing countries. To establish the guideline for nutrition in the very old, we analyzed biochemical and hematological data from 45 Japanese centenarians living in Tokyo metropolitan area during 1994 and 1995.

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Healthy preterm infants admitted to and cared for in the aforementioned neonatal intensive care units. Many intracellular bacterial pathogens previously thought to remain sealed within a vacuole can be recognized by cytosolic innate immune sensors. We show that observers neither completely compensate for nor experience transformations of space as geometry would predict. The contours were shown to correspond to the boundary where part or all of the film was ablated. Exploration of mindfulness in relation to compassion, empathy and reflection within nursing education. The objective of this article is to review clinical and epidemiological characteristics of female gamblers as compared to their male counterparts. However, its molecular mechanism in antitumor activity remains poorly understood. Several limitations and evidences of potential selection bias made this trial fairly controversial. There is a strong need for more studies that explore the impact of such devices on patients, and an equally pressing need for studies that explore the impacts on healthcare services. Assuming that the results of the PAX8 stain performed are accurate at least in most cases, as suggested by the presence of internal positive controls, our study shows that the previously described cytologic features of NA cannot be used as diagnostic criteria, since they are not characteristic for this entity.

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Eleven adolescent girls with type 1 diabetes and poor metabolic control were investigated before and after treatment with PZP, 100 mg orally, twice a day for 3 weeks. (4) Under routine conditions used for gamma-glutamyl transpeptidase estimation, transpeptidation is the prevalent reaction. There was no significant increase in MHPG after the administration of CGS19281A (20 mg/kg). The results of this study suggest that use of a CEA promoter in an adenovirus vector could confer selective expression of the cytosine deaminase gene in CEA-producing gastric cancer cells, rendering the transduced cells susceptible to 5 fluorocytosine. After tolvaptan was approved for the treatment of cirrhosis patients with ascites, only a few studies have reported its efficacy in the real clinical setting, and no studies have reported its contribution to overall survival. Under certain assumptions, low-field MRI acquisitions can be simulated from high-field MRI data. By use of an event log, sexual activity was monitored between screening and the end of treatment. Fatal familial insomnia with a mutation at codon 178 of the prion protein gene: first report from Japan. The use of a symptom checklist (SCL-90-R) as an easy method to estimate the relapse risk after alcoholism detoxification. A brief qualitative experiment and subsequent theoretical study provide new insight concerning off-axis injection of unstable resonators.

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Development, initial reliability and validity testing of an observational tool for assessing technical skills of operating room nurses. Successful conjugation of peptide and DNA adsorption were verified by X-ray photoelectron spectroscopy. Recent developments in free-radical-promoted C-Si formation via selective C-H/Si-H functionalization. Derivation of cat embryonic stem-like cells from in vitro-produced blastocysts on homologous and heterologous feeder cells. It was found to exhibit moderate to good in vitro antimalarial activity against asexual erythrocytic stages of the human malaria parasite Plasmodium falciparum. The adventitial elastin is more fibrous and often contains tubular elastin surrounding vasa vasorum when prepared by removing all non-elastin by placing the aorta in 0.1 N NaOH at 70-75 degrees C for five hours. The intact contralateral femur served as a control for comparison. This strategy will, however, need to be reconsidered as mature results become available from trials of other agents. Twenty-seven patients, who underwent total or partial cystectomy for invasive bladder tumors, were enrolled into the present study. Immune abnormalities in endometriosis compromising fertility in IVF-ET patients.

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We report here a novel mammalian cell-based antibody display platform that displays full-length functional antibodies on the surface of mammalian cells. Our results, and previously published findings, suggest several hotspots for recombination in the pericentromeric heterochromatin of HSA 9. In the present study epidermis reconstructed on de-epidermized dermis was used to investigate the effects of temperature and epidermal growth factor (EGF) on epidermal differentiation and lipogenesis. The study of hexagonal boron nitride (hBN) in microfluidic and nanofluidic applications at the atomic level requires accurate force field parameters to describe the water-hBN interaction. Rates of retinal eye screening, documented foot examinations, and testing for microalbuminuria and hemoglobin A1c have increased substantially. There is an urgent need for high-resolution magnetic-imaging tools capable of characterizing these complex, often buried, nanoscale structures.

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