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Adaple (Adapalene)

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Adaple and Adaple (Retin-A) are different medications, but they are both used to treat mild-to-moderate acne. Adaple contains adapalene, and Retin-A contains Adaple. They both offer a range of benefits and options, so talk to your healthcare provider to discuss which one would be the best fit for you.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

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Anafranil, Mircette, Alprostadil, Adalat, Floxin, Aristocort, Ventolin, Levothroid, Mobic, Buspar, Angiozide, Methadocin, Destres, Alprawin, Albosym, Bronkonat, Klomicina, Zyloric, Addcef, Rokilide,

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Adaple exactly as directed. Adaple is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Adaple. Adaple should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Adaple. Continue using Adaple until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Adaple promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


If you overdose Adaple and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adaple are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Adaple if you are allergic to adapalene.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions.

It is not known whether adapalene passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

It is not known whether Adaple will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Adaple is not approved for use by anyone younger than 12 years old.

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U1-RNP and Toll-like receptors in the pathogenesis of mixed connective tissue diseasePart II. It was a 30 KDa single chain fragment (scFv) with the antigen-binding specificity of the parental monoclonal antibody. Depressive symptoms moderate the relationship between sleep quality and cognitive functions among the elderly. Reconstitution of gammadelta T cell(-/-) mice with gammadelta T cells derived from beta(2)-integrin-deficient mice (CD11a, -b or -c) demonstrated that gammadelta T-cell trafficking to the CNS during EAE is independent of this family of adhesion molecules. Blocking IL-10 in the IL-10Ab/CHX group led to greater increases in hepatic mRNA and serum levels of proinflammatory cytokines, such as TNF-alpha and IL-6. Data on basic socio-demographic and current major medical conditions were also collected. Using a difference-in-differences analysis, we evaluated whether the rates of psychiatric diagnoses among primary care patient populations at 294 VA facilities changed from fiscal year (FY)07 to FY08, and whether trends differed at facilities with PC-MHI encounters in FY08. Association of spindle midzone particles with polo-like kinase 1 during meiosis in mouse and human oocytes. A greater understanding of host response during chlamydial infection is essential to design intervention technique to reduce the increasing incidence rate of genital chlamydial infection. However, re-canalization may be observed up to 2 years after the initial obliteration.

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Posttranslational regulation of Lck and a p36-38 protein by activators of protein kinase C: differential effects of the tumor promoter, PMA, and the non-tumor-promoter, bryostatin. Proliferation of synovium and cartilaginous tissues were identified around the ACL. The role of heterochrony in the establishment of archetype in higher Echinoderm taxa. Epidural abscess is a well-recognised but rare complication of epidural catheter placement. For neurosurgical patients with acute brain injury, the value of CT perfusion is undecided up to now. These studies extend the role of the HmLARs from leech neuronal development to adult neuronal regeneration and provide a platform to investigate neuronal regeneration and gene regulation at the single cell level. In this cell line, multiple genes can be easily and efficiently knocked down by RNA interference (RNAi), and the associated mitotic phenotypes can be assessed with high-resolution microscopy after immunofluorescence or in a living cell. These findings indicate that the mature amino-terminus of gI is required for gE-gI complex formation by the external domains of VZV gE and gI.

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Synthetic photochemistry allows access to molecules that cannot be obtained via more conventional methods. The aim of this study was to explore the restrictions on activity participation that children experience following serious injury from the perspective of their caregivers. New beta lactams and the quinolone class of antibiotics represent major improvements in the therapy of moderate to severe infections. One year after transplantation, isolated extramedullary relapses occurred in lymph nodes and skin, followed by dissemination of blast cells into the BM, whereas the PB cells remained of donor origin. In CKD patients, cardiovascular dysfunction was assessed with aortic pulse wave velocity (AoPWV), carotid artery intima-media thickness (CCA-IMT), coronary artery calcium score (CACS) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) serum concentrations. This system tracks data from 62 pieces of equipment to analyze digital radiographic, mammographic, mobile radiographic, CT, PET-CT, angiographic, and fluorographic modalities. It is a disease of neglect par excellence in remote rural areas.

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Unlike the Mmss mutations, the Cs- mutations are strikingly clustered in the interdomain region of the three-dimensional PCNA monomer structure. How long are elderly patients followed up with mammography after the diagnosis of breast cancer?. Sex differences on the MMPI-2 substance abuse scales in psychiatric inpatients. Early onset muscarinic manifestations after wild mushroom ingestion. The synaptic activity was produced by subthreshold stimuli (0.5 Hz) applied individually, on lumbar splanchnic and lumbar colonic nerves. Here, we isolated AA-reactive HF-specific antigens from normal human scalp anagen HF extracts by immunoprecipitation using serum antibodies from 10 AA patients. Homicide was the most common manner of death, and handguns were the most common type of firearm used in both counties. We describe the western population as a new species, whose range is contained entirely within Western Australia.

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Fungal disease of the Western hemisphere: a patient with coccidioidomycosis. Six patients had hepatocellular carcinoma, 13 patients had hepatic metastasis from colorectal cancer, two had hepatic metastases of breast cancer, two had hepatic metastasis of neuroendocrine tumors, one patient had lymph node metastasis of breast cancer at the hepatic hilum, six patients had pancreatic cancer, and one patient had a neuroendocrine tumor. 5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Only recently a development has started that took interest in the quality of life outcome of TBI patients. Recent studies in autistic children consistently point to neuropathological and functional abnormalities in the temporal association cortex (TeA) and its associated structures. Likewise, supportive literature for a correlation between response to anti-rejection therapy and the severity of rejection lead to the decision that the study should be stratified by a measurement of rejection severity for which Banff criteria were used. Chloroplast RNA-Binding Protein RBD1 Promotes Chilling Tolerance through 23S rRNA Processing in Arabidopsis.

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A brief description of basic rheological concepts related to liquids, solids, and viscoelasticity is presented, including those rheological models commonly used to characterize dairy products. It is concluded that whereas the enhanced fibrinolytic activity during exercise appears to counterbalance the increase in blood coagulability, this haemostatic balance is not maintained during recovery. vivax and recent evidences of severe and complicated vivax malaria across several endemic regions of the world suggest that this disease may have been more overlooked than benign. A growing number of people are deprived of the fundamental right to food, which is essential for all other rights as well as for human existence itself. Here we characterize metabolomics as a comprehensive laboratory tool and review its potential in the diagnosis, prognosis and treatment of rheumatic diseases such as rheumatoid arthritis.

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Relative to the CdSe bulk material, the synthesized CdSe quantum dots showed a blue shift in the measured band gap energy from near infrared spectral region to visible region, making this material very attractive for many solar energy harvesting applications like photo-catalysis and solar cells. Clinical characteristics of hereditary pancreatitis in a large family, based on high-risk haplotype. Data regarding the performance of bedside tests for diagnosing ET are central to the design of research strategies for the clinical evaluation of patients with ET. We present a case of an 82-year-old man with an 11-cm esophageal gastrointestinal stromal tumor who was successfully treated with enucleation. Amphiphilic invertible polymers for adsolubilization on hydrophilic and hydrophobized silica nanoparticles.

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Anatomic evidence obtained through intraoperative examination and preoperative imaging techniques indicates that partial pediculectomy may play a role in the treatment of some cases of lumbar stenosis. In conclusion, the CNGB1b subunit participates in ligand-gated activation of olfactory CNG channels and, particularly, contributes to rapid termination of odorant signal in an olfactory sensory neuron. We therefore report a case where the approximate DFT-based method - DFTB (with which the correct band structure can be effectively obtained) - performs better than the DFT itself with a functional approximation feasible for the modeling of large bio-inorganic interfaces, i.e. Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. However, 17 isolates clustered into eight groups, irrespective of the primer and restriction enzyme used, and in all but one case, the isolates with the same pattern were isolated from the same dairy.

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Viral hepatitis: A lack of hepatocyte STING favours HBV infection. Replacement of standard hospital mattresses and education of staff according to recommendations from the Agency for Health Care Policy and Research guideline for pressure ulcer prediction and prevention did not significantly change the incidence of pressure ulcers during a 3-month period in our skilled-nursing unit. Antioxidant enzymes and survival of normal and simian virus 40-transformed mouse embryo cells after hyperthermia. One class including epidermal growth factor, platelet derived growth factor and fibroblast growth factor activates receptor tyrosine kinases, and the second class, including thrombin, bombesin, bradykinin and vasopressin activates a phosphoinositide-specific phospholipase C through GTP-binding proteins which can be inactivated by pertussis toxin. Incorporating individual and collective ethics into phase I cancer trial designs. Action of heparin in arteriosclerosis: clinical and experimental study.

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Measurement of dexfenfluramine metabolism in rat liver microsomes by gas chromatography-mass spectrometry. We retrospectively analysed the data of 10 eyes of seven patients suffering from a combination of primary open angle glaucoma, optic nerve compartment syndrome, and Flammer syndrome. Signal treatments to reduce heavy vehicle crash-risk at metropolitan highway intersections. The authors draw on their experience of finding simulation exercises to be an exciting method of relating nursing theory to practice. This would imply that U25 could be assigned to the short arm of the river buffalo chromosome 1 (BBU 1p), as U10 has previously been assigned to this chromosome. Exercise during ER mitigated some, but not all, of the bone loss observed in sedentary ER rats, but had little impact on changes in urinary E1G and serum IGF-I and leptin. Although the specific function of the circuits and cellular properties of the thalamic relay for waking behavior is far from clear, we offer two related hypotheses based on recent experimental evidence. Many oncologists use a validated prognostic software model, Adjuvant!, to estimate 10-year recurrence and mortality outcomes for breast cancer local and adjuvant therapy. We used functional testing, noninvasive imaging, and detailed postmortem analysis to assess whether IVIg therapy is effective in a mouse model of severe contusive SCI.

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VLDLP and subfractions of LDLP were isolated by ultracentrifugation. A random sample of women aged 20-64 years was drawn from the demographic file of the city of Faenza (Northern-Italy). Using 58 scales that quantify the verbal, physical, and sexual behavior manifest by a rapist in his interaction with his victim during his first reported rape and 36 modal variables that summarized approach, timing, demographics, and weapon usage across the series of rapes, the study attempts to differentiate between those rapists who escalate in their use of blunt force (Increasers) from those who do not (Non-Increasers). Vection increases the magnitude and accuracy of visually evoked postural responses. The potential benefits of this mini-invasive surgery include decreased operation blood loss, reduced narcotics requirements, shorter hospital stay and recovery time and minimize the parietal trauma. As the core temperature of the liver reaches 20 degrees to 22 degrees C, the aorta and inferior vena cava protonix pantoprazole dosage are clamped just above the diaphragm. Moreover, the strategy described here could help identify drugs for other protein-destabilizing monogenic disorders. The aim of this study was to investigate the prevalence of cleft sidedness, and the number of congenitally missing teeth in regard to cleft type and gender. 1 K-wire fixation group and 5 plate groups were tested for rigidity, yield load, and maximum load.

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Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream. Present and future role of surgery in metastatic gastrointestinal malignancies. Activation of the West Nile virus NS3 protease: molecular dynamics evidence for a conformational selection mechanism. To investigate the effect of CEP on the induction of apoptosis in murine DCs. This often leads to inaccurate assessment of left ventricular function, necessitating the use of other, more expensive and laborious imaging techniques, purely for diagnostic purposes. However, the high frequency of sinus tachycardia seen with the dose used in our study, which was extremely rapid in two patients, indicates the need for further study before the drug can be recommended as a routine premedication for colonoscopy. Clinical characteristics, functional respiratory decline and follow-up in adult patients with primary ciliary dyskinesia. Should cerebral oximetry be used as routine monitoring for cardiovascular surgical cases?. We report a 9-year-old boy with occipital lobe epilepsy who showed a prolonged QTc on the ictal electrocardiogram (ECG). Are adult transcranial Doppler systems suitable for application in neonates?.

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A continuous-wave singly-resonant optical parametric oscillator (SRO) has been implemented using a 20 mm long crystal of periodically poled KTiOPO 4 (PPKTP) intracavity-pumped at room temperature within a Ti:sapphire laser. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. These data suggest that the protein import step of mitochondrial assembly is subject to adaptations under pathophysiological conditions. simplex larvae can induce a specific IgE response with clinical symptoms, usually urticaria, even if the fish is cooked before ingestion and the invasive infestation power destroyed by heating. Finally, the patient died of multiple organ failure induced levaquin pyelonephritis dosing by disseminated intravascular coagulation. The carboxyl terminus of the protein regulates enzymatic activity by forming hydrogen bonds with the surface loop to partially shield the active site.

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Small studies suggest that it is possible to perform wavefront-guided excimer light amplification by stimulated emission of radiation (LASER) to correct ametropia following multifocal lens implantation. This catheter was evaluated in two live anesthetized pigs (four kidneys) and four ex-vivo kidneys. We analyzed three Merkel cell carcinomas (MCC), applying comparative genomic hybridization (CGH) with DNA from paraffin-embedded and cultured tumor material as the probes. We report that the RNA-binding protein PumHD (Pumilio homology domain), which has been widely used in native and modified form for targeting RNA, can be engineered to yield a set of four canonical protein modules, each of which targets one RNA base. In this study, nine strains of Listeria monocytogenes were monitored simultaneously by optical density (OD) analysis and by viable count enumeration (VCE) analysis. Measures of force generation were obtained for the upper lip, lower lip, tongue, and jaw. We describe a method of obtaining rigid fixation across a pars defect without sacrificing a motion segment. Here we report that the two agents that cause oxidative stress, MeHg (1 micro m) and H2O2 (50 micro m), induce translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus in CGC. These were compared with corresponding parameters in 50 eyes that did not develop ectasia for more than 1 year after LASIK.

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Resistance to apoptosis (programmed cell death) is a characteristic feature of human malignancies including pancreatic cancer, which is one of the leading causes of cancer deaths in the western world. Anderson Cancer Center (MDACC) (1980-2007) and the Surveillance, Epidemiology, and End Results (SEER) registry (1988-2004). There were no significant differences between treatment groups for the AUC of VAS scores for postoperative pain, global verbal pain rating or time to first dose of analgesic medication. In the present study we show that kainate-induced seizures result in an increased expression of tenascin-C in rat brain. Priapism associated with cocaine use has been reported only twice in the urological literature.

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From a practical perspective this finding reinforces the concept that life-style changes and pharmacologic treatment aimed to reduce over-weight/obesity and optimize blood pressure are of paramount importance for prevention of subclinical cardiac damage. There was no evidence of systemic hypertension during either procedure. To examine the safety and efficacy of fluoxetine in child and adolescent obsessive-compulsive disorder (OCD). Student QSEN Participation During an Adult Medical-Surgical Rotation. Although it is known that ACE especially cleaves COOH-terminal dipeptides from active polypeptides, the whole range of substrates and products is still unknown. Substantial progress has been made for one-sided hypotheses on the parameters of continuous distributions. Indian men tended to normalise symptoms and the cardiac event, and reported less negative mood symptoms than other groups. Attitudes that determine willingness to seek psychiatric help for depression: a representative population survey applying the Theory of Planned Behaviour.

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In-depth interviews with a purposive sample of 54 junior doctors were carried out. Pre-injection of a receptor tyrosine kinase inhibitor K252a or a specific antibody for TrkB receptors before intracerebroventricular injection of CTZ significantly suppressed the epileptiform activity induced by CTZ. This paper presents details of the presentation, clinical findings, and surgical management of 18 cases of primary small bowel volvulus. Approaches to determining vitamin requirements based on an analysis of the interrelation between the levels of actual consumption and the biochemical allowance parameters. Outcomes were assessed without knowledge of treatment assignment at baseline, 12 weeks, and 5 months. However, in contrast to the ALB, the ACR needs sex- and age-specific discriminator values. The molecular weight of beta-galactosidase was determined by PAG electrophoresis: about 83 kDa. The magnitude of classically conditioned bradycardia was studied in 18-day-old and adult rabbits in which the cerebellar vermis had been surgically removed on either the 5th or 18th postnatal day. Walking beyond the preferred transition speed (PTS) has been proposed as an exercise protocol for boosting energy consumption.

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